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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PCDH7, ADGRE5 (from a repository: Thu Feb 16 16:39:17 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins9 (26.47 %)
The number (and %) of the tumor suppressors2 (5.88 %)
Total number of binary PPIs (saturation %)49 (8.73 %)
The number (and %) of affected PPIs33 (67.35 %)
The number of possible different fusions3
PPI diameter4
PPI radius2
The average degree of PPI2.588
Assortativity coefficient-0.5357
The network average Clustering coefficient0.221
The number (and %) of a zero Clustering coefficients23 (67.65 %)
The number (and %) of a zero Betweenness Centrality23 (67.65 %)


List of the fusions

PPI for parental proteins: ADGRE5,PCDH7 All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); TNF (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ADGRE5parental protein70207.3337tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_MSP1_1 (PF12946, IPR024730): MSP1 EGF domain 1
2 PCDH7parental protein260.015905.000Cadherin_2 (PF08266, IPR013164): Cadherin-like
Protocadherin (PF08374, IPR013585): Protocadherin
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
Cadherin_3 (PF16184): Cadherin-like
3 ABCG2suppressor21.0000ABC2_membrane (PF01061, IPR013525): ABC-2 type transporter
ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
4 C2orf48interactor100NA
5 CAPZA1interactor21.0000F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
6 CAPZA2interactor21.0000F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
7 CEP350interactor100CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
Complex1_LYR_2 (PF13233): Complex1_LYR-like
AAA_23 (PF13476): AAA domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
8 CMSS1interactor100CMS1 (PF14617, IPR032704): U3-containing 90S pre-ribosomal complex subunit
9 CYBRD1interactor21.0000Cytochrom_B561 (PF03188, IPR004877): Eukaryotic cytochrome b561
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
10 DDX28interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 DDX39Ainteractor3022.167DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12 DTWD2interactor100DTW (PF03942, IPR005636, SM01144): DTW domain
13 GOLT1Binteractor40.333173.333Got1 (PF04178, IPR007305): Got1/Sft2-like family
14 HNRNPDoncoprotein50.16725.167CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
15 HNRNPUinteractor30.66714.667CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
16 KLK5oncoprotein100Trypsin (PF00089, IPR001254, SM00020): Trypsin
17 KNL1oncoprotein100DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
18 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
19 MARCKSL1oncoprotein21.0000MARCKS (PF02063, IPR002101): MARCKS family
20 NT5Einteractor1005_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
21 NXPH2interactor100Neurexophilin (PF06312, IPR026845): Neurexophilin
22 PSMD5interactor100Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
23 RAF1oncoprotein3022.167Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
24 RNF113Ainteractor100zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
25 RYKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
26 SYNCRIPinteractor40.33361.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
27 TACC3oncoprotein100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
28 TMEM17interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
29 TMEM171interactor100TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
30 TMEM63Binteractor3020.000RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
31 TNFoncoprotein3014.667TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
32 XRCC5suppressor200Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
33 XRN1interactor204.500XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
34 ZCCHC6interactor100NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
PAP_assoc (PF03828, IPR002058): Cid1 family poly A polymerase
tRNA_NucTransf2 (PF09249, IPR015329): tRNA nucleotidyltransferase, second domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TUTF7_u4 (PF16631): Unstructured region 4 on terminal uridylyltransferase 7

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