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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KIAA0907, ATP6V0A4 (from a repository: Fri Aug 9 23:29:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins7 (41.18 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)44 (32.35 %)
The number (and %) of affected PPIs15 (34.09 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI4.118
Assortativity coefficient-0.3938
The network average Clustering coefficient0.426
The number (and %) of a zero Clustering coefficients5 (29.41 %)
The number (and %) of a zero Betweenness Centrality6 (35.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KHDC4,ATP6V0A4 All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); ZDHHC17 (see 2 fusions); PUF60 (see 1 fusions); PFKM (see 1 fusions); U2AF2 (see 2 fusions); PRPF19 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KIAA0907parental protein140.187137.167NA
2 ATP6V0A4parental protein100V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
3 CDC5Linteractor70.46724.667OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
4 EWSR1oncoprotein50.6671.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
5 EXOC3interactor21.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Sec6 (PF06046, IPR010326): Exocyst complex component Sec6
Tma16 (PF11176, IPR021346): Translation machinery-associated protein 16
6 MOV10interactor40.33315.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
7 NECAP1interactor100DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
8 NXF1interactor50.50011.667NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
9 PFKMprotein found in more fusions5031.833PFK (PF00365, IPR000023): Phosphofructokinase
10 PRPF19protein found in more fusions80.47611.167Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 PUF60protein found in more fusions50.6672.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
12 RBM39oncoprotein50.8001.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
13 SHMT2interactor21.0000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
14 STARD7interactor100START (PF01852, IPR002913, SM00234): START domain
15 U2AF2protein found in more fusions80.47612.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
16 UBE2Minteractor40.6671.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
17 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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