Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GCLC, ATP5B (from a repository: Tue Dec 4 10:17:30 2018)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)144
The number (and %) of the onco-proteins36 (25.00 %)
The number (and %) of the tumor suppressors17 (11.81 %)
Total number of binary PPIs (saturation %)1226 (11.91 %)
The number (and %) of affected PPIs142 (11.58 %)
The number of possible different fusions22
PPI diameter5
PPI radius3
The average degree of PPI16.389
Assortativity coefficient-0.1859
The network average Clustering coefficient0.461
The number (and %) of a zero Clustering coefficients12 (8.33 %)
The number (and %) of a zero Betweenness Centrality23 (15.97 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions STAU1 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); PSME3 (see 2 fusions); OXA1L (see 1 fusions); MDH2 (see 1 fusions); SKI (see 1 fusions); FANCA (see 1 fusions); HDAC5 (see 1 fusions); SUZ12 (see 2 fusions); PTBP1 (see 1 fusions); ILK (see 1 fusions); HSP90AA1 (see 5 fusions); HUWE1 (see 2 fusions); HSP90AB1 (see 3 fusions); CALR (see 6 fusions); ATP5A1/HUWE1 (see 2 fusions); FMNL1 (see 1 fusions); MCM2 (see 1 fusions); EZH2 (see 1 fusions); ATP5A1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GCLCparental protein80.036605.452GCS (PF03074, IPR004308): Glutamate-cysteine ligase
2 ATP5Bparental protein1340.1119961.111AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
3 ACKR3oncoprotein51.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ADRB2interactor120.5275.0617tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 AGLinteractor40.33364.695GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glycogen debranching enzyme, glucanotransferase domain
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
6 ANXA7suppressor70.2869.924Annexin (PF00191, IPR018502, SM00335): Annexin
7 ARAFoncoprotein80.5713.004Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8 ARRB1interactor160.41726.783Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9 ASB11interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
10 ASB5interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
11 ATF2oncoprotein180.30142.516bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
12 ATP5A1protein found in more fusions640.225955.282ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
13 ATP5C1interactor340.333192.670ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
14 ATP5Dinteractor160.65015.570ATP-synt_DE_N (PF02823, IPR020546): ATP synthase, Delta/Epsilon chain, beta-sandwich domain
15 ATP5F1interactor270.399106.701Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
16 ATP5Hinteractor150.51420.552Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
17 ATP5Iinteractor170.50733.913ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
18 ATP5J2interactor70.5713.776WRW (PF10206, IPR019344): Mitochondrial F1F0-ATP synthase, subunit f
19 ATP5MGinteractor140.61510.042ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
20 ATP5POinteractor360.276226.320OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
21 ATP6V0D1interactor170.53724.243vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
22 ATP6V1B2interactor130.43620.738ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
23 ATPAF1interactor100ATP11 (PF06644, IPR010591): ATP11 protein
24 ATPAF2interactor21.0000ATP12 (PF07542, IPR011419): ATP12 chaperone protein
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
25 B4GALT3interactor30.6670.222Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
26 BLKoncoprotein110.7096.467Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27 BMI1oncoprotein110.48913.727zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
28 BTKsuppressor70.6002.626BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
29 CA9interactor40.6670.800Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
Octapeptide (PF03373, IPR005038): Octapeptide repeat
DUF4730 (PF15873, IPR031742): Domain of unknown function (DUF4730)
30 CALRoncoprotein150.49518.723Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
31 CAND1interactor330.429140.194Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
32 CCDC8interactor310.379104.697Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
33 CCL22interactor2019.395IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
34 CDK2suppressor360.319155.236Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
35 CDK4oncoprotein90.5287.436Pkinase (PF00069, IPR000719): Protein kinase domain
36 CDKN1Asuppressor150.47617.983CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
37 CHCHD4interactor100CHCH (PF06747, IPR010625): CHCH domain
Voldacs (PF03517): Regulator of volume decrease after cellular swelling
38 CUL3protein found in more fusions450.270705.143Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
39 CUL7protein found in more fusions310.361104.022ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
40 DHRS11interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
NmrA (PF05368, IPR008030): NmrA-like family
41 DLSToncoprotein1002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
42 DPH5interactor100TP_methylase (PF00590, IPR000878): Tetrapyrrole (Corrin/Porphyrin) Methylases
43 EEF1A1suppressor330.42594.604GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
44 EIF5Ainteractor70.3337.988EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
45 ELAVL1oncoprotein330.175785.248RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
46 ESR1suppressor310.331134.137Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
47 EZH2suppressor130.37924.185CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
48 FAF2interactor200.29879.776DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
49 FANCAoncoprotein40.6670.111Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
50 FBXO25suppressor70.57118.020Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
51 FBXO6interactor320.292146.581FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
52 FBXW11interactor150.40740.745WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
53 FDX1interactor21.0000Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
54 FMNL1protein found in more fusions41.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
55 FN1oncoprotein340.308191.918fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
56 FUSsuppressor330.44993.304Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
57 FZD1interactor100Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region
Fz (PF01392, IPR020067, SM00063): Fz domain
58 GBP1suppressor30.6670.500GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
59 GCLMinteractor2020.426Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
60 GFPT1interactor50.6007.273SIS (PF01380, IPR001347): SIS domain
GATase_6 (PF13522): Glutamine amidotransferase domain
61 GFPT2interactor21.0000SIS (PF01380, IPR001347): SIS domain
GATase_6 (PF13522): Glutamine amidotransferase domain
62 GOLT1Binteractor150.42941.164Got1 (PF04178, IPR007305): Got1/Sft2-like family
63 GRB7interactor21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
64 GRSF1interactor60.4003.856RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
65 HAX1interactor60.7331.229Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
66 HDAC5protein found in more fusions260.44033.853Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
67 HMOX2interactor100Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
68 HNRNPA1interactor390.431153.882RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
69 HNRNPA2B1oncoprotein300.38699.420RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
70 HNRNPA3oncoprotein230.47434.730IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
71 HSP90AA1oncoprotein400.309330.518HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
72 HSP90AB1oncoprotein410.367239.704HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
73 HTR1Einteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
74 HUWE1oncoprotein320.357119.301BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
75 ILKsuppressor110.40018.053Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
76 IPO4interactor60.4004.627HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
77 IRAK1interactor70.5333.472Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
78 ISG15suppressor100.51116.921ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
79 ITGA4interactor310.338106.464FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
80 LNX2interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
81 MAPK3oncoprotein70.4002.486Pkinase (PF00069, IPR000719): Protein kinase domain
82 MAST3interactor31.0000DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
83 MBOAT1interactor31.0000MBOAT (PF03062, IPR004299): MBOAT, membrane-bound O-acyltransferase family
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
DUF3329 (PF11808, IPR021766): Domain of unknown function (DUF3329)
84 MCM2oncoprotein470.317307.016AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
85 MDH2protein found in more fusions190.34037.042Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
86 MRPL58interactor170.34641.196RF-1 (PF00472, IPR000352): RF-1 domain
87 MTCH2interactor240.43869.243Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
88 MYL6interactor100.4895.611EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
89 NDUFA12interactor130.52614.656NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
90 NDUFA2interactor110.38213.131L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
91 NDUFB9interactor110.6009.818Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
92 NDUFS1interactor180.39241.185NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
93 NNTinteractor70.6191.897AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain
PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
94 NPM3interactor41.0000Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
95 NTRK1oncoprotein490.280514.078I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
96 OBSL1interactor250.46041.808BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
97 OXA1Lprotein found in more fusions60.4002.98060KD_IMP (PF02096, IPR001708): 60Kd inner membrane protein
98 P2RY12interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
99 P4HBinteractor260.38361.042Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
100 PA2G4interactor160.5587.032Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
101 PAXIP1interactor50.50031.571BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
102 PHBsuppressor350.269165.632Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
103 PIN1suppressor70.4763.242Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
104 PPIDinteractor90.472183.144Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
105 PPP1CConcoprotein110.41864.763Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
106 PPT1interactor50.9000.250Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
107 PSMA3interactor200.50925.614Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
108 PSMD4interactor120.43926.797UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
109 PSME3protein found in more fusions90.5714.419PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
110 PTBP1oncoprotein280.43968.580RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
111 RNF2interactor250.26499.596zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
112 RPL18interactor270.47956.793Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
113 RPL4interactor250.42357.994Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
114 RPP14interactor203.692RNase_P_Rpp14 (PF01900, IPR002759): Rpp14/Pop5 family
115 RPS2interactor280.354109.801Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
116 RPS3Ainteractor260.53228.239Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
117 SCARNA22interactor60.8670.225NA
118 SDHBsuppressor140.33085.347Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
119 SIRT3suppressor21.0000SIR2 (PF02146, IPR003000): Sir2 family
120 SKIoncoprotein110.5114.404c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
121 SMN1interactor120.4739.091SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
122 SPRTNinteractor80.6073.578GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
123 STAU1protein found in more fusions300.411193.142dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
124 SUZ12suppressor160.37181.262DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
125 TAGLN2interactor110.5097.914Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
126 TERToncoprotein30.6670.100RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase)
Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
127 TK1oncoprotein90.5004.977TK (PF00265, IPR001267, SM00203): Thymidine kinase
128 TMEM63Binteractor110.50923.782RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
129 TOMM22interactor90.44418.417Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
130 TRIM55interactor31.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
131 TRIM63interactor50.5002.667DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
132 TUBA1Aoncoprotein230.39985.146Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
133 TUBA1Cinteractor250.37779.945Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
134 TUBBinteractor300.386158.029Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
135 UBL4Ainteractor260.30580.778ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
136 UQCRC1interactor110.40016.735Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
137 UQCRC2oncoprotein280.37393.046Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
138 VCAM1interactor320.317383.763C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
139 VDAC1interactor240.44973.959Porin_3 (PF01459, IPR027246): Eukaryotic porin
140 VDAC2interactor290.389134.563Porin_3 (PF01459, IPR027246): Eukaryotic porin
141 VDAC3interactor220.46345.380Porin_3 (PF01459, IPR027246): Eukaryotic porin
142 YIPF5interactor90.5008.355Yip1 (PF04893, IPR006977): Yip1 domain
143 YWHAEoncoprotein310.419103.68114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
144 YWHAQinteractor280.45076.33614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑