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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins20 (29.85 %)
The number (and %) of the tumor suppressors14 (20.90 %)
Total number of binary PPIs (saturation %)306 (13.84 %)
The number (and %) of affected PPIs67 (21.90 %)
The number of possible different fusions15
PPI diameter5
PPI radius3
The average degree of PPI8.090
Assortativity coefficient-0.3383
The network average Clustering coefficient0.408
The number (and %) of a zero Clustering coefficients16 (23.88 %)
The number (and %) of a zero Betweenness Centrality15 (22.39 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DEC1,SRI All fusions
Proteins found in more fusions STAT3 (see 2 fusions); CRY2 (see 3 fusions); TKT (see 5 fusions); SSNA1 (see 2 fusions); SMAD2 (see 2 fusions); HDAC1 (see 1 fusions); GSK3B (see 1 fusions); TCF12 (see 2 fusions); RYR2 (see 1 fusions); CSNK2A1 (see 1 fusions); PPP2R5E (see 1 fusions); EZH2 (see 1 fusions); SRPK2 (see 1 fusions); CSNK1E (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DEC1parental protein320.284456.689DEC1 (PF15859, IPR031718): Deleted in esophageal cancer 1 family
2 SRIparental protein350.0621841.757EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
3 ALG2interactor40.6670.967Glycos_transf_1 (PF00534, IPR001296): Glycosyl transferases group 1
Glyco_transf_4 (PF13439, IPR028098): Glycosyltransferase Family 4
4 ANXA7suppressor50.5008.387Annexin (PF00191, IPR018502, SM00335): Annexin
5 ARNTLsuppressor90.7783.860HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
6 ATXN3interactor50.333125.929Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
7 BHLHE41suppressor160.49541.178Adeno_PIX (PF03955, IPR005641): Adenovirus hexon-associated protein (IX)
Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
8 C12orf57interactor2015.921P_C10 (PF14974, IPR026317): Protein C10
9 CACNA1Cinteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Rer1 (PF03248, IPR004932): Rer1 family
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
10 CACNA1Sinteractor100Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
COX16 (PF14138, IPR020164): Cytochrome c oxidase assembly protein COX16
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
11 CALCOCO2interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
12 CIPCinteractor40.8330.202CiPC (PF15800, IPR031602): Clock interacting protein circadian
13 CLOCKinteractor190.48551.527DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PAS (PF00989, IPR013767, SM00091): PAS fold
RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
PAS_11 (PF14598): PAS domain
FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
14 CRY1interactor170.50090.432DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
15 CRY2protein found in more fusions150.48427.831DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
16 CSNK1Eprotein found in more fusions160.59022.916APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
17 CSNK2A1oncoprotein90.46455.881Pkinase (PF00069, IPR000719): Protein kinase domain
18 CSNK2A2interactor50.7002.384Pkinase (PF00069, IPR000719): Protein kinase domain
19 CSNK2Binteractor300.249689.588CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
20 ENO1oncoprotein90.44451.343Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
21 EZH2suppressor70.40050.151CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
22 FBXL15interactor30.6670.202LRV (PF01816, IPR004830): Leucine rich repeat variant
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
23 FN1oncoprotein130.346281.463fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
24 GCAinteractor200EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
DUF2835 (PF11197, IPR021363): Protein of unknown function (DUF2835)
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
25 GSK3Bsuppressor80.38149.460Pkinase (PF00069, IPR000719): Protein kinase domain
26 HAUS2interactor2013.434DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
27 HDAC1suppressor180.287241.376FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
28 HDAC2suppressor90.35736.706Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
29 ITGA4interactor130.439188.339FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
30 MPIinteractor21.0000PMI_typeI (PF01238, IPR001250): Phosphomannose isomerase type I
31 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
32 NFIL3interactor200Vert_IL3-reg_TF (PF06529, IPR010533): Vertebrate interleukin-3 regulated transcription factor
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
33 NONOoncoprotein120.38267.127GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PAS_7 (PF12860): PAS fold
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
34 NPAS2suppressor70.8100.914HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
DehI (PF10778, IPR019714): Halocarboxylic acid dehydrogenase DehI
PAS_11 (PF14598): PAS domain
35 NR1D2interactor70.5247.744zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
36 NRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
37 PDCD6IPinteractor100.41785.252BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
38 PDE4Cinteractor100PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
39 PER1oncoprotein50.9000.346PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SPX (PF03105, IPR004331): SPX domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
40 PER2suppressor80.8570.914PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
41 PIRinteractor70.52429.677Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
42 PPP1CAsuppressor180.320269.902Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
43 PPP1CBinteractor80.67926.299Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
44 PPP1CConcoprotein100.62239.462Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
45 PPP2CAsuppressor120.424180.309Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
46 PPP2R1Aoncoprotein130.47496.894TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
47 PPP2R1Bsuppressor140.60356.794HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
48 PPP2R5Dinteractor110.63615.689B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
49 PPP2R5Eprotein found in more fusions130.69713.688B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
50 PRR13interactor200DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
51 PSEN2oncoprotein200Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
52 RORBinteractor40.8330.202zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
53 RORConcoprotein190.33988.201zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
54 RUVBL1oncoprotein4089.692TIP49 (PF06068, IPR010339): TIP49 C-terminus
55 RYR2protein found in more fusions60.400131.071Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
YjfB_motility (PF14070, IPR025906): Putative motility protein
56 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
57 SMAD2suppressor70.26788.513MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
58 SNCAinteractor4047.729Synuclein (PF01387, IPR001058): Synuclein
59 SOD1interactor100.38958.182Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
60 SRPK2oncoprotein200DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
61 SSNA1protein found in more fusions200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
62 STAT3suppressor50.33371.926SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
63 TCF12oncoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
64 TIAL1interactor60.5334.797RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
65 TKTprotein found in more fusions90.53614.166Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
66 VAPAinteractor50.7001.100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
67 VCAM1interactor110.364187.485C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain

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