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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins10 (25.00 %)
The number (and %) of the tumor suppressors2 (5.00 %)
Total number of binary PPIs (saturation %)148 (18.97 %)
The number (and %) of affected PPIs38 (25.68 %)
The number of possible different fusions8
PPI diameter4
PPI radius2
The average degree of PPI6.800
Assortativity coefficient-0.3564
The network average Clustering coefficient0.474
The number (and %) of a zero Clustering coefficients10 (25.00 %)
The number (and %) of a zero Betweenness Centrality12 (30.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PDE8B,ALDH7A1 All fusions
Proteins found in more fusions SORD (see 1 fusions); EPS8 (see 1 fusions); APP (see 5 fusions); YWHAG (see 1 fusions); XRCC4 (see 1 fusions); YWHAH (see 2 fusions); G6PD (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PDE8Bparental protein100PDE8 (PF08629, IPR013938): PDE8 phosphodiesterase
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
PAS_9 (PF13426, IPR000014): PAS domain
2 ALDH7A1parental protein370.1311003.638Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4 APPprotein found in more fusions80.38112.167APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ASNSoncoprotein100.60010.605Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
6 CAPN2interactor60.7337.388Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CAPNS1interactor120.59112.102EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CATsuppressor70.6004.733Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
9 CPT2interactor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
10 DDA1interactor30.6670.333DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
11 EIF5interactor130.44940.029CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
12 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 ERP44interactor40.6670.733Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
14 FAHD2Ainteractor31.0000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
15 FERMT2interactor90.61115.576FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
16 G6PDprotein found in more fusions120.52728.183G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
17 GLAinteractor40.8330.500Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
18 GOT1interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
19 HIBCHinteractor100ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
20 HMGB3interactor31.0000HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
21 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
22 KIF2Ainteractor200Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
23 L3HYPDHinteractor100Pro_racemase (PF05544, IPR008794): Proline racemase
24 LDHBinteractor100.47217.700Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
25 PDIA4interactor90.6397.586Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
26 PGDoncoprotein70.6675.3676PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
27 PPIAinteractor30.6670.400Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
28 PPP1CAsuppressor80.6798.760Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
29 PRDX5interactor40.8330.400Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
30 SCPEP1interactor70.7626.960Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
31 SORDprotein found in more fusions70.5336.333ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
32 STK24interactor90.6439.521DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
33 TBCBinteractor120.59113.971CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
34 UBA5interactor305.017Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
35 XPO1interactor120.28898.588CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
36 XRCC4protein found in more fusions200XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
37 YWHAEoncoprotein140.54926.17614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
38 YWHAGprotein found in more fusions110.55621.65514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
39 YWHAHprotein found in more fusions140.55128.49514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
40 YWHAQinteractor90.7225.08314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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