Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ALDH7A1, PRKCH (from a repository: Tue Dec 4 22:01:16 2018)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins11 (22.45 %)
The number (and %) of the tumor suppressors5 (10.20 %)
Total number of binary PPIs (saturation %)174 (14.80 %)
The number (and %) of affected PPIs48 (27.59 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI6.408
Assortativity coefficient-0.2205
The network average Clustering coefficient0.438
The number (and %) of a zero Clustering coefficients13 (26.53 %)
The number (and %) of a zero Betweenness Centrality16 (32.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PRKCH,ALDH7A1 All fusions
Proteins found in more fusions PRKCH (see 1 fusions); EPS8 (see 1 fusions); APP (see 4 fusions); YWHAG (see 1 fusions); HSP90AA1 (see 5 fusions); VHL (see 1 fusions); YWHAH (see 2 fusions); G6PD (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PRKCHparental protein110.133302.990C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2 ALDH7A1parental protein370.1311228.258Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4 AKAP13oncoprotein30.33323.433APG6 (PF04111, IPR007243): Autophagy protein Apg6
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
RII_binding_1 (PF10522, IPR018459): RII binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
5 APPprotein found in more fusions120.182240.059APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ASNSoncoprotein110.54553.123Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
7 BANPsuppressor200DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
8 CAPN2interactor51.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CAPNS1interactor120.59116.783EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
10 CATsuppressor70.60012.771Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
11 CDK2suppressor150.253368.521Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CPT2interactor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
13 DDA1interactor30.6670.333DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
14 EIF5interactor120.45538.098CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
15 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 ERP44interactor40.6670.800Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
17 FAHD2Ainteractor31.0000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
18 FERMT2interactor80.67913.298FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
19 G6PDprotein found in more fusions110.55618.297G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
20 GLAinteractor40.8330.500Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
21 GOT1interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
22 GSK3Ainteractor30.33310.992Pkinase (PF00069, IPR000719): Protein kinase domain
23 HIBCHinteractor100ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
24 HMGB3interactor31.0000HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
25 HSP90AA1oncoprotein80.33354.988HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
26 KBTBD7interactor2021.981BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
27 KIF2Ainteractor200Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
28 L3HYPDHinteractor100Pro_racemase (PF05544, IPR008794): Proline racemase
29 LDHBinteractor110.46746.962Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
30 MGMTinteractor31.0000DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
31 NFE2L2oncoprotein100bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
32 PDIA4interactor100.57839.038Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
33 PGDoncoprotein80.60740.0976PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
34 PPIAinteractor40.50010.497Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
35 PPP1CAsuppressor80.64325.871Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
36 PPP1R14Ainteractor2013.444PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
37 PRDX5interactor40.8330.733Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
38 SCPEP1interactor60.8670.619Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
39 SORDinteractor70.5339.019ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
40 STK24interactor80.7142.252DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
41 TBCBinteractor120.59116.621CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
42 UBA5interactor200Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
43 VHLsuppressor50.66713.944Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
44 XRCC4interactor200XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
45 YWHAEoncoprotein140.52756.84914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
46 YWHAGprotein found in more fusions130.424149.33114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
47 YWHAHprotein found in more fusions140.53850.70214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
48 YWHAQinteractor100.68920.79614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
49 ZBTB8OSinteractor100Archease (PF01951, IPR023572): Archease protein family (MTH1598/TM1083)

B a c k    t o    T o p ⇑