1 |
CFLAR | parental protein | 38 | 0.162 | 1237.122 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
2 |
NUP88 | parental protein | 29 | 0.298 | 488.641 | Nup88 (PF10168, IPR019321): Nuclear pore component |
3 |
ARFGEF2 | interactor | 3 | 0.667 | 0.667 | DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2 |
4 |
ATG3 | interactor | 1 | 0 | 0 | Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain |
5 |
BCL2L1 | oncoprotein | 5 | 0.667 | 2.060 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 |
6 |
CAND1 | interactor | 14 | 0.487 | 58.072 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
7 |
CASP10 | interactor | 14 | 0.526 | 20.809 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
8 |
CASP3 | interactor | 10 | 0.444 | 35.462 | Peptidase_C14 (PF00656, IPR011600): Caspase domain |
9 |
CASP8 | suppressor | 22 | 0.329 | 251.369 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
10 |
CBLB | oncoprotein | 5 | 0.500 | 29.005 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
11 |
CIRBP | oncoprotein | 6 | 0.733 | 3.509 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
12 |
CNTROB | interactor | 1 | 0 | 0 | DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) FadA (PF09403, IPR018543): Adhesion protein FadA Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) |
13 |
CPSF6 | interactor | 7 | 0.571 | 13.637 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
14 |
CUL2 | suppressor | 12 | 0.591 | 23.186 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
15 |
CUL3 | protein found in more fusions | 25 | 0.293 | 576.067 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
16 |
DAXX | oncoprotein | 8 | 0.429 | 23.982 | Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) |
17 |
DDX19A | interactor | 5 | 0.800 | 0.756 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
18 |
DEDD | interactor | 8 | 0.476 | 56.899 | DED (PF01335, IPR001875, SM00031): Death effector domain |
19 |
DEDD2 | interactor | 5 | 1.000 | 0 | DED (PF01335, IPR001875, SM00031): Death effector domain |
20 |
DOK2 | suppressor | 1 | 0 | 0 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
21 |
FADD | suppressor | 14 | 0.516 | 78.686 | Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain |
22 |
FAS | suppressor | 11 | 0.622 | 10.788 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH |
23 |
FASLG | interactor | 6 | 1.000 | 0 | PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
24 |
FLNC | interactor | 4 | 0.500 | 17.611 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain |
25 |
G3BP2 | interactor | 10 | 0.444 | 23.676 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
26 |
GSN | suppressor | 4 | 0.667 | 3.519 | Gelsolin (PF00626, IPR007123): Gelsolin repeat |
27 |
HSP90AA1 | oncoprotein | 15 | 0.308 | 216.862 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
28 |
IFI16 | suppressor | 12 | 0.727 | 28.951 | HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein |
29 |
ITCH | interactor | 10 | 0.361 | 91.494 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
30 |
KPNB1 | protein found in more fusions | 21 | 0.458 | 141.985 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat |
31 |
MAP3K14 | interactor | 10 | 0.694 | 10.020 | Pkinase (PF00069, IPR000719): Protein kinase domain |
32 |
MCM3 | interactor | 6 | 0.733 | 5.057 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
33 |
NOD1 | oncoprotein | 5 | 0.500 | 1.573 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain NACHT (PF05729): NACHT domain Sigma54_AID (PF00309, IPR000394): Sigma-54 factor, Activator interacting domain (AID) SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
34 |
NOL3 | oncoprotein | 5 | 1.000 | 0 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) |
35 |
NTRK1 | oncoprotein | 19 | 0.327 | 185.232 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
36 |
NUP107 | interactor | 17 | 0.596 | 43.857 | Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107 |
37 |
NUP153 | protein found in more fusions | 17 | 0.633 | 41.133 | Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region |
38 |
NUP214 | oncoprotein | 19 | 0.529 | 60.001 | dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 |
39 |
NUP35 | interactor | 9 | 0.889 | 1.353 | Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif |
40 |
NUP62 | interactor | 16 | 0.524 | 128.235 | Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region |
41 |
NUP85 | interactor | 10 | 0.800 | 4.856 | Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin |
42 |
NUP98 | suppressor | 12 | 0.682 | 26.646 | Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head |
43 |
NXF1 | interactor | 24 | 0.316 | 382.483 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
44 |
PLIN5 | interactor | 1 | 0 | 0 | Perilipin (PF03036, IPR004279): Perilipin family |
45 |
RAE1 | interactor | 12 | 0.758 | 21.265 | Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
46 |
RAF1 | oncoprotein | 6 | 0.600 | 19.139 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
47 |
RBM42 | interactor | 3 | 1.000 | 0 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
48 |
REV3L | interactor | 1 | 0 | 0 | DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666) DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683) |
49 |
RIPK1 | protein found in more fusions | 16 | 0.486 | 44.513 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif |
50 |
RIPK2 | interactor | 8 | 0.524 | 47.102 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
51 |
RNF2 | interactor | 9 | 0.214 | 98.458 | zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like |
52 |
SEH1L | interactor | 11 | 0.873 | 3.356 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein |
53 |
SET | oncoprotein | 5 | 0.500 | 5.610 | NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) |
54 |
SF3B3 | interactor | 9 | 0.444 | 93.146 | CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term |
55 |
SIRT7 | interactor | 10 | 0.533 | 33.429 | DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family |
56 |
SMAD3 | oncoprotein | 10 | 0.361 | 82.786 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
57 |
SPATS1 | interactor | 1 | 0 | 0 | SASRP1 (PF15160, IPR029165): Spermatogenesis-associated serine-rich protein 1 |
58 |
STUB1 | suppressor | 9 | 0.429 | 27.011 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
59 |
SUZ12 | suppressor | 8 | 0.429 | 10.996 | DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein |
60 |
TICAM1 | protein found in more fusions | 8 | 0.762 | 3.892 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator RHIM (PF12721, IPR025735): RIP homotypic interaction motif TIR_2 (PF13676, IPR000157): TIR domain |
61 |
TNFRSF10A | suppressor | 8 | 0.786 | 21.371 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region TMIE (PF16038, IPR032006): TMIE protein |
62 |
TNFRSF10B | suppressor | 12 | 0.621 | 52.882 | Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
63 |
TNFSF10 | oncoprotein | 9 | 0.786 | 2.357 | NERD (PF08378, IPR011528): Nuclease-related domain TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family |
64 |
TP53 | suppressor | 18 | 0.176 | 335.723 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
65 |
TRAF1 | oncoprotein | 11 | 0.711 | 5.864 | HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain |
66 |
TRAF2 | interactor | 15 | 0.451 | 62.939 | MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger) |
67 |
TRAF3 | oncoprotein | 13 | 0.409 | 116.153 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29 |
68 |
XRCC6 | oncoprotein | 10 | 0.333 | 88.747 | Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain |