Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	68
The number (and %) of the onco-proteins	21 (30.88 %)
The number (and %) of the tumor suppressors	13 (19.12 %)
Total number of binary PPIs (saturation %)	378 (16.59 %)
The number (and %) of affected PPIs	67 (17.72 %)
The number of possible different fusions	17
PPI diameter	5
PPI radius	3
The average degree of PPI	10.000
Assortativity coefficient	-0.2246
The network average Clustering coefficient	0.514
The number (and %) of a zero Clustering coefficients	6 (8.82 %)
The number (and %) of a zero Betweenness Centrality	10 (14.71 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CFLAR,NUP88	All fusions
Proteins found in more fusions	NUP153 (see 2 fusions); NOD1 (see 1 fusions); TNFSF10 (see 1 fusions); RIPK1 (see 1 fusions); BCL2L1 (see 1 fusions); HSP90AA1 (see 6 fusions); TICAM1 (see 1 fusions); NUP214 (see 2 fusions); KPNB1 (see 2 fusions); CUL3 (see 1 fusions); NOL3 (see 2 fusions); CBLB (see 4 fusions); SET (see 1 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); SUZ12 (see 2 fusions);

List of the fusions

PPI for parental proteins: CFLAR,NUP88

All fusions

Proteins found in more fusions

NUP153 (see 2 fusions); NOD1 (see 1 fusions); TNFSF10 (see 1 fusions); RIPK1 (see 1 fusions); BCL2L1 (see 1 fusions); HSP90AA1 (see 6 fusions); TICAM1 (see 1 fusions); NUP214 (see 2 fusions); KPNB1 (see 2 fusions); CUL3 (see 1 fusions); NOL3 (see 2 fusions); CBLB (see 4 fusions); SET (see 1 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); SUZ12 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CFLAR	parental protein	38	0.162	1237.122	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
2	NUP88	parental protein	29	0.298	488.641	Nup88 (PF10168, IPR019321): Nuclear pore component
3	ARFGEF2	interactor	3	0.667	0.667	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
4	ATG3	interactor	1	0	0	Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
5	BCL2L1	oncoprotein	5	0.667	2.060	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
6	CAND1	interactor	14	0.487	58.072	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7	CASP10	interactor	14	0.526	20.809	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
8	CASP3	interactor	10	0.444	35.462	Peptidase_C14 (PF00656, IPR011600): Caspase domain
9	CASP8	suppressor	22	0.329	251.369	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
10	CBLB	oncoprotein	5	0.500	29.005	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1
11	CIRBP	oncoprotein	6	0.733	3.509	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12	CNTROB	interactor	1	0	0	DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) FadA (PF09403, IPR018543): Adhesion protein FadA Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
13	CPSF6	interactor	7	0.571	13.637	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
14	CUL2	suppressor	12	0.591	23.186	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
15	CUL3	protein found in more fusions	25	0.293	576.067	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
16	DAXX	oncoprotein	8	0.429	23.982	Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
17	DDX19A	interactor	5	0.800	0.756	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18	DEDD	interactor	8	0.476	56.899	DED (PF01335, IPR001875, SM00031): Death effector domain
19	DEDD2	interactor	5	1.000	0	DED (PF01335, IPR001875, SM00031): Death effector domain
20	DOK2	suppressor	1	0	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
21	FADD	suppressor	14	0.516	78.686	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
22	FAS	suppressor	11	0.622	10.788	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
23	FASLG	interactor	6	1.000	0	PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family PRIMA1 (PF16101): Proline-rich membrane anchor 1
24	FLNC	interactor	4	0.500	17.611	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
25	G3BP2	interactor	10	0.444	23.676	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26	GSN	suppressor	4	0.667	3.519	Gelsolin (PF00626, IPR007123): Gelsolin repeat
27	HSP90AA1	oncoprotein	15	0.308	216.862	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
28	IFI16	suppressor	12	0.727	28.951	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
29	ITCH	interactor	10	0.361	91.494	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
30	KPNB1	protein found in more fusions	21	0.458	141.985	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
31	MAP3K14	interactor	10	0.694	10.020	Pkinase (PF00069, IPR000719): Protein kinase domain
32	MCM3	interactor	6	0.733	5.057	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
33	NOD1	oncoprotein	5	0.500	1.573	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain NACHT (PF05729): NACHT domain Sigma54_AID (PF00309, IPR000394): Sigma-54 factor, Activator interacting domain (AID) SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
34	NOL3	oncoprotein	5	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
35	NTRK1	oncoprotein	19	0.327	185.232	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
36	NUP107	interactor	17	0.596	43.857	Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
37	NUP153	protein found in more fusions	17	0.633	41.133	Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
38	NUP214	oncoprotein	19	0.529	60.001	dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
39	NUP35	interactor	9	0.889	1.353	Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
40	NUP62	interactor	16	0.524	128.235	Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
41	NUP85	interactor	10	0.800	4.856	Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
42	NUP98	suppressor	12	0.682	26.646	Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head
43	NXF1	interactor	24	0.316	382.483	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
44	PLIN5	interactor	1	0	0	Perilipin (PF03036, IPR004279): Perilipin family
45	RAE1	interactor	12	0.758	21.265	Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
46	RAF1	oncoprotein	6	0.600	19.139	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
47	RBM42	interactor	3	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRIMA1 (PF16101): Proline-rich membrane anchor 1
48	REV3L	interactor	1	0	0	DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666) DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683)
49	RIPK1	protein found in more fusions	16	0.486	44.513	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
50	RIPK2	interactor	8	0.524	47.102	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
51	RNF2	interactor	9	0.214	98.458	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
52	SEH1L	interactor	11	0.873	3.356	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
53	SET	oncoprotein	5	0.500	5.610	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
54	SF3B3	interactor	9	0.444	93.146	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
55	SIRT7	interactor	10	0.533	33.429	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
56	SMAD3	oncoprotein	10	0.361	82.786	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
57	SPATS1	interactor	1	0	0	SASRP1 (PF15160, IPR029165): Spermatogenesis-associated serine-rich protein 1
58	STUB1	suppressor	9	0.429	27.011	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
59	SUZ12	suppressor	8	0.429	10.996	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
60	TICAM1	protein found in more fusions	8	0.762	3.892	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator RHIM (PF12721, IPR025735): RIP homotypic interaction motif TIR_2 (PF13676, IPR000157): TIR domain
61	TNFRSF10A	suppressor	8	0.786	21.371	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region TMIE (PF16038, IPR032006): TMIE protein
62	TNFRSF10B	suppressor	12	0.621	52.882	Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
63	TNFSF10	oncoprotein	9	0.786	2.357	NERD (PF08378, IPR011528): Nuclease-related domain TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
64	TP53	suppressor	18	0.176	335.723	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
65	TRAF1	oncoprotein	11	0.711	5.864	HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
66	TRAF2	interactor	15	0.451	62.939	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
67	TRAF3	oncoprotein	13	0.409	116.153	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29
68	XRCC6	oncoprotein	10	0.333	88.747	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain

B a c k t o T o p ⇑

Fusion ID: Protein names:	4927 8837
Level of PPIs:	or Upload text file:	Update repository

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List of active interactors