1 |
PHLPP1 | parental protein | 27 | 0.100 | 801.475 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
2 |
NUP88 | parental protein | 29 | 0.298 | 450.233 | Nup88 (PF10168, IPR019321): Nuclear pore component |
3 |
AKT1 | oncoprotein | 6 | 0.400 | 7.471 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
4 |
ARFGEF2 | interactor | 3 | 0.667 | 1.678 | DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2 |
5 |
BRAP | interactor | 3 | 0 | 6.878 | BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2 DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH |
6 |
BTRC | oncoprotein | 8 | 0.429 | 38.233 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
7 |
CAND1 | interactor | 13 | 0.515 | 31.197 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
8 |
CIRBP | oncoprotein | 7 | 0.714 | 5.854 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
9 |
CNTROB | interactor | 1 | 0 | 0 | DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) FadA (PF09403, IPR018543): Adhesion protein FadA Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) |
10 |
CPSF6 | interactor | 7 | 0.571 | 12.475 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
11 |
CSNK1A1 | suppressor | 5 | 0.500 | 17.785 | Pkinase (PF00069, IPR000719): Protein kinase domain |
12 |
CUL2 | suppressor | 11 | 0.564 | 63.271 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
13 |
CUL3 | protein found in more fusions | 21 | 0.363 | 317.134 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
14 |
DDX19A | interactor | 5 | 0.800 | 1.570 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
15 |
DMWD | interactor | 7 | 0.429 | 61.149 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
16 |
EFNB2 | interactor | 1 | 0 | 0 | Ephrin (PF00812, IPR001799): Ephrin TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term |
17 |
ELAVL1 | oncoprotein | 20 | 0.216 | 316.102 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
18 |
FKBP5 | interactor | 5 | 0.400 | 33.575 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain |
19 |
FLNC | interactor | 4 | 0.500 | 7.347 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain |
20 |
G3BP2 | interactor | 10 | 0.533 | 20.912 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
21 |
GSK3B | suppressor | 5 | 0.667 | 8.225 | Pkinase (PF00069, IPR000719): Protein kinase domain |
22 |
HDAC1 | suppressor | 6 | 0.300 | 46.238 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
23 |
IFI16 | suppressor | 13 | 0.615 | 55.029 | HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein |
24 |
KPNB1 | protein found in more fusions | 18 | 0.596 | 52.398 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat |
25 |
MAPK8 | oncoprotein | 6 | 0.400 | 40.733 | DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain |
26 |
MARK2 | protein found in more fusions | 4 | 0.333 | 12.401 | DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
27 |
MCM3 | interactor | 6 | 0.600 | 19.161 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
28 |
NTRK1 | oncoprotein | 25 | 0.188 | 485.547 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
29 |
NUP107 | interactor | 17 | 0.596 | 45.595 | Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107 |
30 |
NUP153 | protein found in more fusions | 16 | 0.705 | 15.990 | Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region |
31 |
NUP214 | oncoprotein | 18 | 0.581 | 40.999 | dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 |
32 |
NUP35 | interactor | 9 | 0.889 | 1.352 | Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif |
33 |
NUP62 | interactor | 15 | 0.604 | 22.028 | Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region |
34 |
NUP85 | interactor | 10 | 0.800 | 8.581 | Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin |
35 |
NUP98 | suppressor | 14 | 0.505 | 110.246 | Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head |
36 |
NXF1 | interactor | 22 | 0.357 | 166.603 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
37 |
PHLPP2 | suppressor | 8 | 0.500 | 16.438 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat IMUP (PF15761, IPR026621): Immortalisation up-regulated protein |
38 |
PPP5C | interactor | 3 | 0 | 10.343 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat |
39 |
RAE1 | interactor | 11 | 0.873 | 4.170 | Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
40 |
RBM15 | oncoprotein | 7 | 0.286 | 56.511 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC (PF07744, IPR012921): SPOC domain Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain |
41 |
RBM42 | interactor | 3 | 1.000 | 0 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
42 |
RFPL2 | interactor | 2 | 1.000 | 0 | SPRY (PF00622, IPR003877, SM00449): SPRY domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain RDM (PF11002, IPR022723): RFPL defining motif (RDM) zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
43 |
RNF2 | interactor | 7 | 0.533 | 12.579 | zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like |
44 |
SCRIB | suppressor | 4 | 0.167 | 15.492 | Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SDA1 (PF05285, IPR007949): SDA1 DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat LRR_9 (PF14580): Leucine-rich repeat AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM |
45 |
SEH1L | interactor | 12 | 0.742 | 17.664 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein |
46 |
SET | oncoprotein | 6 | 0.400 | 39.149 | NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) |
47 |
SIRT7 | interactor | 10 | 0.533 | 26.523 | DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family |
48 |
SLC9A3R2 | interactor | 2 | 1.000 | 0 | EBP50_C (PF09007, IPR015098): EBP50, C-terminal GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
49 |
SNX27 | interactor | 4 | 0.500 | 19.083 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PX (PF00787, IPR001683, SM00312): PX domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain |
50 |
SNX6 | interactor | 4 | 0.333 | 27.993 | PX (PF00787, IPR001683, SM00312): PX domain Vps5 (PF09325, IPR015404): Vps5 C terminal like |
51 |
SUGT1 | interactor | 3 | 0.667 | 3.028 | CheC (PF04509, IPR007597): CheC-like family CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
52 |
SUZ12 | suppressor | 10 | 0.361 | 30.290 | DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein |
53 |
USP1 | protein found in more fusions | 4 | 1.000 | 0 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
54 |
USP12 | suppressor | 6 | 0.867 | 1.000 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
55 |
USP46 | interactor | 8 | 0.536 | 22.025 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
56 |
WBSCR22 | interactor | 2 | 0 | 4.868 | Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain WBS_methylT (PF12589, IPR022238): Methyltransferase involved in Williams-Beuren syndrome |
57 |
WDR20 | interactor | 5 | 1.000 | 0 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
58 |
WDR48 | suppressor | 10 | 0.422 | 165.377 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337) |