Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins NUP88, PHLPP1 (from a repository: Sat Aug 3 05:48:00 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 58 The number (and %) of the onco-proteins 14 (24.14 %) The number (and %) of the tumor suppressors 11 (18.97 %) Total number of binary PPIs (saturation %) 274 (16.58 %) The number (and %) of affected PPIs 56 (20.44 %) The number of possible different fusions 9 PPI diameter 5 PPI radius 3 The average degree of PPI 8.759 Assortativity coefficient -0.1318 The network average Clustering coefficient 0.508 The number (and %) of a zero Clustering coefficients 5 (8.62 %) The number (and %) of a zero Betweenness Centrality 7 (12.07 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PHLPP1,NUP88	All fusions
Proteins found in more fusions	NUP153 (see 2 fusions); NUP214 (see 2 fusions); KPNB1 (see 2 fusions); CUL3 (see 1 fusions); MARK2 (see 2 fusions); USP1 (see 1 fusions); SET (see 1 fusions); SUZ12 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PHLPP1	parental protein	27	0.100	801.475	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat PRIMA1 (PF16101): Proline-rich membrane anchor 1
2	NUP88	parental protein	29	0.298	450.233	Nup88 (PF10168, IPR019321): Nuclear pore component
3	AKT1	oncoprotein	6	0.400	7.471	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4	ARFGEF2	interactor	3	0.667	1.678	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
5	BRAP	interactor	3	0	6.878	BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2 DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
6	BTRC	oncoprotein	8	0.429	38.233	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
7	CAND1	interactor	13	0.515	31.197	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
8	CIRBP	oncoprotein	7	0.714	5.854	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9	CNTROB	interactor	1	0	0	DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) FadA (PF09403, IPR018543): Adhesion protein FadA Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
10	CPSF6	interactor	7	0.571	12.475	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
11	CSNK1A1	suppressor	5	0.500	17.785	Pkinase (PF00069, IPR000719): Protein kinase domain
12	CUL2	suppressor	11	0.564	63.271	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13	CUL3	protein found in more fusions	21	0.363	317.134	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14	DDX19A	interactor	5	0.800	1.570	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15	DMWD	interactor	7	0.429	61.149	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16	EFNB2	interactor	1	0	0	Ephrin (PF00812, IPR001799): Ephrin TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
17	ELAVL1	oncoprotein	20	0.216	316.102	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18	FKBP5	interactor	5	0.400	33.575	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
19	FLNC	interactor	4	0.500	7.347	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
20	G3BP2	interactor	10	0.533	20.912	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21	GSK3B	suppressor	5	0.667	8.225	Pkinase (PF00069, IPR000719): Protein kinase domain
22	HDAC1	suppressor	6	0.300	46.238	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23	IFI16	suppressor	13	0.615	55.029	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
24	KPNB1	protein found in more fusions	18	0.596	52.398	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
25	MAPK8	oncoprotein	6	0.400	40.733	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
26	MARK2	protein found in more fusions	4	0.333	12.401	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
27	MCM3	interactor	6	0.600	19.161	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
28	NTRK1	oncoprotein	25	0.188	485.547	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
29	NUP107	interactor	17	0.596	45.595	Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
30	NUP153	protein found in more fusions	16	0.705	15.990	Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
31	NUP214	oncoprotein	18	0.581	40.999	dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
32	NUP35	interactor	9	0.889	1.352	Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
33	NUP62	interactor	15	0.604	22.028	Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
34	NUP85	interactor	10	0.800	8.581	Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
35	NUP98	suppressor	14	0.505	110.246	Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head
36	NXF1	interactor	22	0.357	166.603	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
37	PHLPP2	suppressor	8	0.500	16.438	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
38	PPP5C	interactor	3	0	10.343	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat
39	RAE1	interactor	11	0.873	4.170	Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
40	RBM15	oncoprotein	7	0.286	56.511	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC (PF07744, IPR012921): SPOC domain Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
41	RBM42	interactor	3	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRIMA1 (PF16101): Proline-rich membrane anchor 1
42	RFPL2	interactor	2	1.000	0	SPRY (PF00622, IPR003877, SM00449): SPRY domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain RDM (PF11002, IPR022723): RFPL defining motif (RDM) zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
43	RNF2	interactor	7	0.533	12.579	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
44	SCRIB	suppressor	4	0.167	15.492	Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SDA1 (PF05285, IPR007949): SDA1 DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat LRR_9 (PF14580): Leucine-rich repeat AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
45	SEH1L	interactor	12	0.742	17.664	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
46	SET	oncoprotein	6	0.400	39.149	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
47	SIRT7	interactor	10	0.533	26.523	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
48	SLC9A3R2	interactor	2	1.000	0	EBP50_C (PF09007, IPR015098): EBP50, C-terminal GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
49	SNX27	interactor	4	0.500	19.083	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PX (PF00787, IPR001683, SM00312): PX domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
50	SNX6	interactor	4	0.333	27.993	PX (PF00787, IPR001683, SM00312): PX domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
51	SUGT1	interactor	3	0.667	3.028	CheC (PF04509, IPR007597): CheC-like family CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
52	SUZ12	suppressor	10	0.361	30.290	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
53	USP1	protein found in more fusions	4	1.000	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
54	USP12	suppressor	6	0.867	1.000	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
55	USP46	interactor	8	0.536	22.025	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
56	WBSCR22	interactor	2	0	4.868	Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain WBS_methylT (PF12589, IPR022238): Methyltransferase involved in Williams-Beuren syndrome
57	WDR20	interactor	5	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
58	WDR48	suppressor	10	0.422	165.377	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)

B a c k    t o    T o p ⇑