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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)124
The number (and %) of the onco-proteins36 (29.03 %)
The number (and %) of the tumor suppressors20 (16.13 %)
Total number of binary PPIs (saturation %)506 (6.64 %)
The number (and %) of affected PPIs124 (24.51 %)
The number of possible different fusions25
PPI diameter4
PPI radius2
The average degree of PPI7.403
Assortativity coefficient-0.2987
The network average Clustering coefficient0.447
The number (and %) of a zero Clustering coefficients21 (16.94 %)
The number (and %) of a zero Betweenness Centrality35 (28.23 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NFYC,YES1 All fusions
Proteins found in more fusions TRAF6 (see 1 fusions); CDH1 (see 3 fusions); KHDRBS1 (see 1 fusions); MAPRE1 (see 1 fusions); KAT2B (see 1 fusions); HSP90AA1 (see 6 fusions); SMAD2 (see 2 fusions); ZDHHC17 (see 2 fusions); EGFR (see 2 fusions); EPHB2 (see 1 fusions); BECN1 (see 1 fusions); CUL7 (see 2 fusions); TNK2 (see 1 fusions); PTK2 (see 3 fusions); FXR2 (see 1 fusions); SLC9A3R1 (see 2 fusions); FYN (see 1 fusions); SLC25A11 (see 1 fusions); NEDD4 (see 1 fusions); MYC (see 2 fusions); SP1 (see 1 fusions); SMAD3 (see 3 fusions); GAPDH (see 5 fusions); SREBF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NFYCparental protein390.1162520.542CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Fucose_iso_C (PF02952, IPR015888): L-fucose isomerase, C-terminal domain
2 YES1parental protein850.0528443.516Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
3 ACSL3oncoprotein30.6671.467AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
4 ADAM15interactor21.0000CD20 (PF04103, IPR007237): CD20-like family
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
5 ADNP2interactor21.0000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
6 ANKRD12oncoprotein21.0000CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
UPF0767 (PF15990, IPR031933): UPF0767 family
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
7 ANLNoncoprotein100.60052.929Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
8 ARID2suppressor100ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
9 ARRB1interactor120.227310.838Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10 ATF6interactor60.8003.372bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
11 ATF6Binteractor41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
12 ATP6V1E1interactor100vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
13 BECN1suppressor50.5002.262APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
14 BICRAsuppressor100SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
15 C1orf94interactor200DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
16 CBLsuppressor140.218262.781Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
17 CCNL2interactor30.33328.998Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
18 CCR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
19 CD36interactor21.0000CD36 (PF01130, IPR002159): CD36 family
20 CD46oncoprotein100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
DUF3188 (PF11384, IPR021524): Protein of unknown function (DUF3188)
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
21 CDH1suppressor80.47645.048Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
22 CDK2suppressor220.262355.805Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
23 CICsuppressor21.0000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRI (PF15325, IPR028278): Modulator of retrovirus infection
DUF4819 (PF16090, IPR032147): Domain of unknown function (DUF4819)
24 CORO1Binteractor80.50049.890DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
25 CORO1Concoprotein130.436112.951DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WD40_4 (PF16300): Type of WD40 repeat
26 CSF1Roncoprotein60.5334.752ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
27 CSN2interactor2012.770Casein (PF00363, IPR001588): Casein
28 CTNND1suppressor60.46710.233Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
29 CUL7protein found in more fusions120.25589.046ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
30 CYP51A1interactor30.6673.462p450 (PF00067, IPR001128): Cytochrome P450
31 DBN1oncoprotein140.484108.002Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
32 DOK1suppressor50.6672.167IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
33 DR1interactor50.6004.786CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
34 DSToncoprotein100.400131.669CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Phasin (PF05597, IPR008769): Poly(hydroxyalcanoate) granule associated protein (phasin)
Spectrin (PF00435, IPR002017): Spectrin repeat
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
XhlA (PF10779, IPR019715): Haemolysin XhlA
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
NYD-SP28 (PF14772): Sperm tail
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
35 DVL2interactor90.250193.573DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
36 DYNLT1interactor40.33314.936Tctex-1 (PF03645, IPR005334): Tctex-1 family
37 EGFRoncoprotein220.186304.418Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
38 ELAVL1oncoprotein310.1241888.052RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39 EPHB2suppressor31.0000EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
40 FAF2interactor40.6671.664DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
41 FASLGinteractor30.6670.333PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
42 FCGR2Ainteractor2012.554DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
43 FLOT1interactor80.50011.643CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
44 FN1oncoprotein180.229267.653fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
45 FOXJ2interactor40.66723.478SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
46 FOXK2interactor50.40063.366FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
47 FUNDC1interactor100FUN14 (PF04930, IPR007014): FUN14 family
48 FXR2protein found in more fusions70.40010.400Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
49 FYNoncoprotein290.101432.008Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
50 FYTTD1interactor200FYTT (PF07078, IPR009782): Forty-two-three protein
51 GAPDHoncoprotein90.32184.748Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
52 GLTSCR1Linteractor21.0000DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein
53 GPR35interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
54 GRPEL2interactor21.0000GrpE (PF01025, IPR000740): GrpE
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
55 HDAC1suppressor190.209429.677FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
56 HNRNPH1oncoprotein80.50016.224RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
57 HOXB5interactor21.0000DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
58 HSP90AA1oncoprotein180.287223.827HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
59 ILF2interactor80.35796.544DZF (PF07528, IPR006561, SM00572): DZF domain
60 JSRP1interactor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
61 KAT2Bprotein found in more fusions120.40066.235Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
62 KHDRBS1protein found in more fusions70.26736.175KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
63 KIToncoprotein30.6671.810ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
64 LIMA1suppressor160.400112.636LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
65 LIMCH1interactor60.66715.568LIM (PF00412, IPR001781, SM00132): LIM domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
DUF3435 (PF11917, IPR021842): Protein of unknown function (DUF3435)
DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
66 LMO4interactor30.33343.305LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
67 MAPRE1oncoprotein100.36186.441CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
68 MED28interactor40.6675.171cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
69 MYConcoprotein190.333821.374HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
70 MYH9suppressor190.363215.950IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
71 NEDD4suppressor130.212153.660Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
72 NFKBIAoncoprotein50.40048.178Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
73 NFYAinteractor120.39465.559CBFB_NFYA (PF02045, IPR001289): CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
MSP1_C (PF07462, IPR010901): Merozoite surface protein 1 (MSP1) C-terminus
FixG_C (PF11614, IPR032879): IG-like fold at C-terminal of FixG, putative oxidoreductase
DUF4237 (PF14021, IPR025331): Protein of unknown function (DUF4237)
74 NFYBinteractor130.50052.536CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
75 NIF3L1interactor50.50059.133NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
76 NPHS1interactor31.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4643 (PF15485, IPR028004): Domain of unknown function (DUF4643)
77 NSUN2interactor30.6671.167Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
78 OCLNinteractor21.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
79 OGTinteractor50.40029.047TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
80 OLIG1interactor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
81 PAN2interactor110.43645.328RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
82 PDCD6IPinteractor60.7004.456BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
83 PDLIM7interactor60.40014.438LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
84 PECAM1oncoprotein31.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
85 PIFOinteractor100SHIPPO-rpt (PF07004, IPR010736): Sperm-tail PG-rich repeat
86 POGZinteractor40.6672.141DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease
Rubredoxin (PF00301, IPR024935): Rubredoxin
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
HTH_28 (PF13518): Helix-turn-helix domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
87 PPP1CBinteractor150.429107.586Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
88 PTENsuppressor110.255101.517DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
89 PTK2protein found in more fusions120.43644.714FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
90 RASA1oncoprotein80.35722.579C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
91 RPL10suppressor80.32120.065Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
92 SLC16A14interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
93 SLC25A11protein found in more fusions50.5004.296Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
94 SLC25A41interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
95 SLC30A4interactor100Cation_efflux (PF01545, IPR002524): Cation efflux family
96 SLC9A3R1suppressor31.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
97 SMAD2suppressor110.46786.686MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
98 SMAD3oncoprotein110.46765.242MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
99 SNAP23interactor80.38183.492DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SNAP-25 (PF00835, IPR000928): SNAP-25 family
DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
100 SNX2interactor3047.692PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
101 SOCS3suppressor80.39341.354SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
102 SP1protein found in more fusions160.381259.306zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
103 SPRR2Ainteractor100SPRR2 (PF14820, IPR029142): Small proline-rich 2
104 SREBF2protein found in more fusions80.42955.644HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
105 SSBP3oncoprotein20100.810SSDP (PF04503): Single-stranded DNA binding protein, SSDP
106 TAF11interactor50.70012.929CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
TAFII28 (PF04719, IPR006809): hTAFII28-like protein conserved region
107 TAF12interactor80.64341.752TFIID_20kDa (PF03847, IPR003228): Transcription initiation factor TFIID subunit A
108 TAF6interactor60.8671.508CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
109 TBPinteractor130.43972.535TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
110 TBPL2interactor100TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
111 THAP1interactor50.5003.653THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
112 TMEM17interactor80.17999.439Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
113 TMEM185Ainteractor21.0000Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
114 TNK2protein found in more fusions70.60037.836CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
115 TP73suppressor90.50063.930P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
116 TRAF2interactor100.30656.132MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
117 TRAF6protein found in more fusions80.33312.278SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
118 TRIM27oncoprotein50.16760.346IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
119 TRPV4interactor21.0000Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
120 TSR1interactor21.0000AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
121 USF3interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
122 ZBTB8Ainteractor40.6671.200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
123 ZDHHC17protein found in more fusions60.50029.392zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
124 ZNF512Binteractor2019.400YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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