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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NFIC, TRAPPC10 (from a repository: Thu Aug 8 19:15:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins9 (23.08 %)
The number (and %) of the tumor suppressors3 (7.69 %)
Total number of binary PPIs (saturation %)123 (16.60 %)
The number (and %) of affected PPIs38 (30.89 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI5.590
Assortativity coefficient-0.2751
The network average Clustering coefficient0.441
The number (and %) of a zero Clustering coefficients10 (25.64 %)
The number (and %) of a zero Betweenness Centrality10 (25.64 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TRAPPC10,NFIC All fusions
Proteins found in more fusions AMOTL2 (see 1 fusions); CREB1 (see 1 fusions); HSP90AA1 (see 6 fusions); TRAPPC10 (see 1 fusions); TRAPPC8 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRAPPC10parental protein190.333344.353Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
TRAPPC10 (PF12584, IPR022233): Trafficking protein particle complex subunit 10, TRAPPC10
2 NFICparental protein190.088570.697CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
3 AMOTL2protein found in more fusions31.0000HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
4 BCL2L14interactor80.57110.246Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
CF222 (PF15661, IPR031362): C6orf222, uncharacterised family
5 CABS1interactor70.5719.096CABS1 (PF15367, IPR026118): Calcium-binding and spermatid-specific protein 1
6 CREB1oncoprotein50.5002.333bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
7 CTR9interactor100DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
8 DMTNinteractor100VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
9 ELAVL1oncoprotein100.222451.851RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 FOXA1suppressor40.66711.504Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
HNF_C (PF09354, IPR018533): HNF3 C-terminal domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
11 FOXC1suppressor30.66710.837TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PAF (PF15715, IPR031444): PCNA-associated factor
PRIMA1 (PF16101): Proline-rich membrane anchor 1
12 FOXE1oncoprotein30.6670.667Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
13 GPD2interactor100DAO (PF01266, IPR006076): FAD dependent oxidoreductase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DAO_C (PF16901, IPR031656): C-terminal domain of alpha-glycerophosphate oxidase
14 HSP90AA1oncoprotein200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
15 LLPHinteractor100Laps (PF10169, IPR018784): Learning-associated protein
16 NCBP1interactor100MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
17 NFIBoncoprotein30.6672.000CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
DUF3383 (PF11863, IPR021808): Protein of unknown function (DUF3383)
18 NOTCH1suppressor60.100192.123Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
19 RBPJinteractor40.50038.083BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
20 RDXinteractor3083.463ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
21 RFX1interactor30.33332.770Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RFX1_trans_act (PF04589, IPR007668): RFX1 transcription activation region
RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
22 SMAD3oncoprotein50.33360.770MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
23 SMURF1interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
24 TFAP4oncoprotein50.60019.896DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
25 TKTL2interactor2022.593Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
26 TPD52L3interactor100TPD52 (PF04201, IPR007327): Tumour protein D52 family
27 TRAPPC1interactor50.5001.357Sybindin (PF04099, IPR007233): Sybindin-like family
28 TRAPPC12interactor120.65513.646TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
29 TRAPPC2interactor130.545380.388Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
30 TRAPPC2Linteractor110.6895.074Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
31 TRAPPC3Linteractor110.65513.646TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
32 TRAPPC4interactor110.7785.104Sybindin (PF04099, IPR007233): Sybindin-like family
33 TRAPPC5interactor60.6671.357TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
34 TRAPPC6Ainteractor70.9332.264TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
35 TRAPPC6Binteractor90.8064.264TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
36 TRAPPC8protein found in more fusions90.9292.514TRAPPC-Trs85 (PF12739, IPR024420): ER-Golgi trafficking TRAPP I complex 85 kDa subunit
SNAP (PF14938): Soluble NSF attachment protein, SNAP
37 TRAPPC9interactor110.54565.107PMBR (PF09373, IPR018975): Pseudomurein-binding repeat
TRAPPC9-Trs120 (PF08626, IPR013935): Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
Vps23_core (PF09454, IPR017916): Vps23 core domain
38 ZCCHC14interactor30.6672.000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SPX (PF03105, IPR004331): SPX domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
39 ZKSCAN7interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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