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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NEK3, TM9SF2 (from a repository: Sun May 21 07:25:30 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins1 (6.25 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)21 (17.50 %)
The number (and %) of affected PPIs14 (66.67 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.125
Assortativity coefficient-0.4990
The network average Clustering coefficient0.225
The number (and %) of a zero Clustering coefficients11 (68.75 %)
The number (and %) of a zero Betweenness Centrality13 (81.25 %)


List of the fusions

PPI for parental proteins: NEK3,TM9SF2 All fusions
Proteins found in more fusions SMAD4 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 NEK3parental protein6030.000Pkinase (PF00069, IPR000719): Protein kinase domain
2 TM9SF2parental protein80.10747.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
EMP70 (PF02990, IPR004240): Endomembrane protein 70
3 ATP1B3interactor100Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
4 BPGMinteractor100Exc (PF07825, IPR012884): Excisionase-like protein
His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
5 CDCA8interactor200Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
6 CDK13interactor100K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Macoilin (PF09726, IPR019130): Transmembrane protein
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
7 HDAC6oncoprotein200Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
8 MMGT1interactor21.0000MMgT (PF10270, IPR018937): Membrane magnesium transporter
9 NMNAT1interactor200CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
10 RPN2interactor21.0000Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
11 SLC25A3interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
12 SMAD4suppressor200MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
13 SRSF7interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
14 TCTN3interactor40.5003.000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
15 UNC93B1interactor21.0000UNC-93 (PF05978, IPR010291): Ion channel regulatory protein UNC-93
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
16 VSIG4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain

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