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Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)159
The number (and %) of the onco-proteins37 (23.27 %)
The number (and %) of the tumor suppressors14 (8.81 %)
Total number of binary PPIs (saturation %)4951 (39.42 %)
The number (and %) of affected PPIs159 (3.21 %)
The number of possible different fusions32
PPI diameter4
PPI radius2
The average degree of PPI61.799
Assortativity coefficient-0.0439
The network average Clustering coefficient0.696
The number (and %) of a zero Clustering coefficients7 (4.40 %)
The number (and %) of a zero Betweenness Centrality11 (6.92 %)


List of the fusions

PPI for parental proteins: PTPRG,RPL10A All fusions
Proteins found in more fusions NTRK1/TFG (see 1 fusions); VHL (see 1 fusions); HDAC5 (see 1 fusions); HNRNPU/RPL24 (see 1 fusions); RPLP2 (see 1 fusions); CUL4A (see 4 fusions); RPS24/RPS23 (see 1 fusions); RPS24/RPS27 (see 1 fusions); RPL27/RPS6 (see 1 fusions); HUWE1 (see 2 fusions); EEF1A1/RPL12 (see 1 fusions); RPL38/RPL3 (see 1 fusions); RPS19/RPS14 (see 1 fusions); TUBG1 (see 1 fusions); NTRK1/RPL7A (see 1 fusions); CUL3 (see 1 fusions); NAP1L1 (see 4 fusions); COPS5 (see 1 fusions); TP53 (see 3 fusions); FN1/RPL6 (see 1 fusions); CUL1 (see 3 fusions); DLG4 (see 1 fusions); CENPQ (see 1 fusions); HSP90AB1 (see 3 fusions); CUL7 (see 2 fusions); S100A10 (see 1 fusions); ACTB (see 5 fusions); PTPRG (see 3 fusions); DHX8 (see 1 fusions); PABPC1 (see 2 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PTPRGparental protein70642.799Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
TMEM119 (PF15724, IPR031453): TMEM119 family
2 RPL10Aparental protein1520.4143761.351Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
3 ACTA2interactor190.7132.804Actin (PF00022, IPR004000, SM00268): Actin
4 ACTBoncoprotein220.4487.709Actin (PF00022, IPR004000, SM00268): Actin
5 BRIX1interactor330.69723.110Brix (PF04427, IPR007109, SM00879): Brix domain
6 CAND1interactor1010.647194.882Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7 CCDC8interactor460.69341.645Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
8 CCNL2interactor2012.436Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
9 CDK2suppressor730.69867.475Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
10 CDK5RAP3interactor60.7330.375DUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
11 CENPQprotein found in more fusions90.571307.300CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
12 CENPUinteractor30.6670.571Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CENP-U (PF13097, IPR025214): CENP-A nucleosome associated complex (NAC) subunit
13 CEP250interactor600.77431.907ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
14 COPS5protein found in more fusions900.686122.293JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 CUL1suppressor930.662296.314Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
16 CUL3protein found in more fusions950.629486.753Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
17 CUL4Aprotein found in more fusions360.64928.087Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
18 CUL5suppressor660.73349.996Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
19 CUL7protein found in more fusions660.63381.709ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
20 DCCsuppressor100.9560.053fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
21 DDX27interactor210.6389.474Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
22 DHX8protein found in more fusions130.5914.001DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DLG4protein found in more fusions40118.681L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
24 EEF1A1suppressor680.71168.321GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
25 EEF2interactor520.71223.504EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
26 ESR1suppressor720.68187.865Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
27 FCN1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
28 FN1oncoprotein830.696230.689fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
29 FYTTD1interactor70.467523.061FYTT (PF07078, IPR009782): Forty-two-three protein
30 GTPBP4suppressor280.55636.340DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MRC1 (PF09444, IPR018564): MRC1-like domain
NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1)
NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain
Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus
AAA_16 (PF13191): AAA ATPase domain
31 GZF1interactor51.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
32 HDAC5protein found in more fusions320.69012.484Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
33 HIST1H1Ainteractor160.43341.111Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
34 HIST2H2BFinteractor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
35 HNRNPMinteractor610.76525.657RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
36 HNRNPUprotein found in more fusions980.673138.834CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
37 HSP90AB1oncoprotein460.61724.726HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
38 HUWE1oncoprotein540.72047.434BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
39 ILF2interactor620.71837.845DZF (PF07528, IPR006561, SM00572): DZF domain
40 ILF3oncoprotein760.71958.213dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
41 ITGA4interactor690.721195.542FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
42 LGALS8interactor50.100263.563Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
43 LOC101929876interactor590.9731.873NA
44 MCM2oncoprotein910.607236.130AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
45 MDM2oncoprotein360.583128.676Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
46 MRTO4interactor180.6993.155Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
47 NAP1L1protein found in more fusions320.74211.199NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
48 NOL8interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TMPIT (PF07851, IPR012926): TMPIT-like protein
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
49 NOP2interactor490.65856.843BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
P120R (PF08062, IPR012586): P120R (NUC006) repeat
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477)
FAM176 (PF14851): FAM176 family
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
50 NOP56interactor750.73087.814Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
51 NPM1suppressor1060.586403.057Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
52 NTRK1oncoprotein640.592128.440I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
53 OBSL1interactor490.60368.049BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
54 PABPC1oncoprotein590.70228.484RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
55 PAN2interactor730.790151.898RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
56 POLR1Ainteractor70.6670.461RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
57 PRR11interactor120.5303.895CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PRIMA1 (PF16101): Proline-rich membrane anchor 1
58 PSMB1interactor110.8360.489Proteasome (PF00227, IPR001353): Proteasome subunit
59 PTENsuppressor330.73111.803DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
60 RAD18interactor41.0000PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
61 RGS17interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
62 RNF2interactor590.626151.123zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
63 RNPS1interactor220.7492.971RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
64 RPL10suppressor990.710259.538Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
65 RPL10Linteractor690.85554.191Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
Cytochrome_P460 (PF16694, IPR032033): Cytochrome P460
66 RPL11suppressor1040.72884.361Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
67 RPL12protein found in more fusions1000.742121.459Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
68 RPL13interactor940.76568.128Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
69 RPL13Ainteractor870.78881.134Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
70 RPL14interactor1170.596662.389KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
71 RPL15interactor1060.678321.986Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
72 RPL17interactor860.77846.872Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
73 RPL18interactor1050.725151.139Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
74 RPL18Ainteractor920.77954.149Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
75 RPL19interactor960.76559.672DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
76 RPL21interactor1010.74670.605Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
77 RPL22oncoprotein920.80339.834Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family
78 RPL23interactor1020.717112.101Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
79 RPL23Ainteractor1040.723112.793Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
80 RPL24protein found in more fusions930.79857.063MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
81 RPL26L1interactor500.73773.923Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
82 RPL27protein found in more fusions890.79456.772Ribosomal_L27e (PF01777, IPR001141): Ribosomal L27e protein family
83 RPL27Ainteractor870.81049.583Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
84 RPL29interactor400.8764.075BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Ribosomal_L29e (PF01779, IPR002673): Ribosomal L29e protein family
85 RPL3protein found in more fusions1010.724119.935Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
86 RPL30interactor850.84026.328NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
87 RPL31interactor940.76271.395Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
88 RPL32interactor620.82742.928Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
89 RPL34interactor610.9156.063Redoxin (PF08534, IPR013740): Redoxin
Ribosomal_L34e (PF01199, IPR008195): Ribosomal protein L34e
90 RPL35interactor810.86123.054Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
91 RPL35Ainteractor640.89923.162Ribosomal_L35Ae (PF01247, IPR001780): Ribosomal protein L35Ae
92 RPL36interactor820.84631.412Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
93 RPL36ALinteractor130.5008.880NOB1_Zn_bind (PF08772, IPR014881): Nin one binding (NOB1) Zn-ribbon like
Ribosomal_L44 (PF00935, IPR000552): Ribosomal protein L44
94 RPL37Ainteractor830.85422.470Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
95 RPL38protein found in more fusions800.83939.295Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
96 RPL4interactor1080.683153.763Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
97 RPL5suppressor1200.607420.960Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
98 RPL6protein found in more fusions1130.655339.055Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
99 RPL7interactor1080.691119.589Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
100 RPL7Aprotein found in more fusions1090.664161.391Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
101 RPL8interactor960.75168.754Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
102 RPL9interactor1000.732184.605Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
103 RPLP0interactor1050.711104.438Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
104 RPLP0P6interactor690.82827.308NA
105 RPLP1interactor710.87714.995Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
106 RPLP2protein found in more fusions860.78983.451Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
107 RPS10interactor890.81146.337S10_plectin (PF03501, IPR005326): Plectin/S10 domain
108 RPS11interactor940.779107.530Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
109 RPS12interactor810.85620.206Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
110 RPS13interactor1020.724117.041Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
111 RPS14protein found in more fusions980.754124.804Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
112 RPS15Ainteractor1030.715113.041Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
113 RPS16interactor1040.733144.415Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
114 RPS18interactor890.81634.873Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
115 RPS19protein found in more fusions900.82032.138Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
116 RPS2interactor1100.688193.604Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
117 RPS20interactor880.81837.270Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
118 RPS21interactor710.88511.251Ribosomal_S21e (PF01249, IPR001931): Ribosomal protein S21e
119 RPS23protein found in more fusions960.74583.141Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
120 RPS24protein found in more fusions900.78652.961Fascin (PF06268, IPR022768): Fascin domain
Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
121 RPS25interactor950.78449.369Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
122 RPS26interactor860.78946.836Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
123 RPS27protein found in more fusions770.84638.906Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
124 RPS27Ainteractor530.86710.058DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
125 RPS27Linteractor510.9076.992E7 (PF00527, IPR000148): E7 protein, Early protein
Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
126 RPS28interactor660.87410.575Ribosomal_S28e (PF01200, IPR000289): Ribosomal protein S28e
127 RPS3interactor1080.682190.248KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
128 RPS3Ainteractor1110.674194.452Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
129 RPS4Xinteractor1120.676145.235KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
130 RPS5interactor920.77997.502Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
131 RPS6protein found in more fusions1090.689124.469Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
132 RPS7interactor900.79543.274Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e
133 RPS8interactor1060.72387.906Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
134 RPS9interactor940.77355.835Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain
S4 (PF01479, IPR002942, SM00363): S4 domain
135 RPSAinteractor990.722126.664Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
136 RRP1Binteractor180.7392.174Nop52 (PF05997, IPR010301): Nucleolar protein,Nop52
137 S100A10oncoprotein50.8330.024S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
138 SIRT7interactor550.634101.731DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
139 SLC25A5interactor510.78714.405Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
140 SLC25A6interactor170.4855.043Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
141 SRPRAinteractor40.8330.048SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SRP54 (PF00448, IPR000897, SM00962): SRP54-type protein, GTPase domain
SRP54_N (PF02881, IPR013822, SM00963): SRP54-type protein, helical bundle domain
142 SSR3interactor41.0000TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
143 TARDBPinteractor640.82416.743RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
144 TFGoncoprotein130.6215.825ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
145 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
146 TP53suppressor770.64593.099DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
147 TUBB4Binteractor290.40416.236Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
148 TUBG1protein found in more fusions500.73539.937Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
149 UBL4Ainteractor800.713130.699ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
150 URB1interactor70.6671.792Npa1 (PF11707, IPR021714): Ribosome 60S biogenesis N-terminal
NopRA1 (PF16201, IPR032436): Nucleolar pre-ribosomal-associated protein 1
151 VCAM1interactor690.75549.632C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
152 VHLsuppressor350.74715.266Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
153 WDR89interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
154 XPO1interactor540.614130.278CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
155 YWHAQinteractor250.58012.43814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
156 ZC3H3interactor110.4365.196zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
157 ZCCHC7interactor21.0000zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
zf-CCHC_3 (PF13917): Zinc knuckle
158 ZNF707interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
159 ZRSR2interactor40.6670.230Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26

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