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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)86
The number (and %) of the onco-proteins13 (15.12 %)
The number (and %) of the tumor suppressors3 (3.49 %)
Total number of binary PPIs (saturation %)646 (17.67 %)
The number (and %) of affected PPIs84 (13.00 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI14.628
Assortativity coefficient-0.1569
The network average Clustering coefficient0.526
The number (and %) of a zero Clustering coefficients4 (4.65 %)
The number (and %) of a zero Betweenness Centrality6 (6.98 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NDUFS4,SBF2 All fusions
Proteins found in more fusions APP (see 5 fusions); ATP1A1/VDAC3 (see 2 fusions); PARK2 (see 1 fusions); RBPMS (see 1 fusions); HNRNPD (see 1 fusions); NDUFS3 (see 2 fusions); ALDOA (see 2 fusions); UBC (see 7 fusions); ATP5A1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NDUFS4parental protein730.1782634.180ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
2 SBF2parental protein110.291210.715dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
PH (PF00169, IPR001849, SM00233): PH domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
SBF2 (PF12335, IPR022096): Myotubularin protein
3 ABCD3interactor60.6004.415ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 ALDOAprotein found in more fusions50.5003.744Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
5 ALDOCinteractor40.5003.771Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
6 APPprotein found in more fusions180.301106.538APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ATAD3Ainteractor70.5245.903AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
8 ATP1A1protein found in more fusions140.63714.414Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9 ATP2A2interactor40.6671.912Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10 ATP5A1protein found in more fusions170.58346.856ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
11 ATP5C1interactor180.60122.613ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
12 ATP5F1interactor190.49139.926Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
13 ATP5POinteractor190.55028.990OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
14 ATP6V0D1interactor190.46855.636vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
15 BAG6interactor50.50010.726DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 CACNA2D1interactor100dCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
17 COX15interactor70.7622.119COX15-CtaA (PF02628, IPR003780): Cytochrome oxidase assembly protein
Peptidase_S3 (PF00944, IPR000930): Alphavirus core protein
18 COX4I1interactor130.55116.159COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
19 COX6B1interactor100.6944.539COX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIb
20 COX7A2Linteractor50.7000.700COX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII
21 CYC1interactor210.37680.304Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
22 DLATinteractor70.47613.3452-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
Stm1_N (PF09598, IPR019084): Stm1
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
23 DNAJC30interactor40.5001.429DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
24 FBXW11interactor80.33335.229WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
25 FUBP1oncoprotein40.5001.715DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
26 FUBP3interactor50.40015.498DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
27 GOLT1Binteractor310.443106.113Got1 (PF04178, IPR007305): Got1/Sft2-like family
28 HNRNPDoncoprotein90.39323.748CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
29 M6PRinteractor21.0000Man-6-P_recep (PF02157, IPR028927): Mannose-6-phosphate receptor
30 MARC1interactor60.3338.905MOSC (PF03473, IPR005302): MOSC domain
MOSC_N (PF03476, IPR005303): MOSC N-terminal beta barrel domain
31 MGST3interactor31.0000MAPEG (PF01124, IPR001129): MAPEG family
32 MRPL15interactor90.41724.217Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
33 MT-ND5interactor90.9720.083NADH5_C (PF06455, IPR010934): NADH dehydrogenase subunit 5 C-terminus
Proton_antipo_M (PF00361, IPR001750): Proton-conducting membrane transporter
Proton_antipo_N (PF00662, IPR001516): NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
34 ND1interactor80.9640.083NA
35 ND4interactor60.9330.083NA
36 NDUFA11interactor210.66718.0107kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
37 NDUFA12interactor350.455130.235NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
38 NDUFA13interactor150.77115.500GRIM-19 (PF06212, IPR009346): GRIM-19 protein
39 NDUFA2interactor170.64714.122L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
40 NDUFA4interactor330.433112.579B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
41 NDUFA7interactor130.61512.796CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
42 NDUFA8interactor280.49757.837CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
43 NDUFA9interactor340.487128.968Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
44 NDUFAF3interactor110.7822.356DUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
45 NDUFB10interactor140.65912.689NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
46 NDUFB4interactor170.58144.632NDUF_B4 (PF07225, IPR009866): NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
47 NDUFB5interactor140.61584.299NDUF_B5 (PF09781, IPR019173): NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
48 NDUFB8interactor180.52932.017NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
49 NDUFS1interactor310.499124.407NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
50 NDUFS2interactor240.55178.533Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
51 NDUFS3protein found in more fusions370.435201.763Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
52 NDUFS5interactor280.53762.266Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
53 NDUFS6interactor230.67226.528Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
54 NDUFS7interactor200.7848.610Oxidored_q6 (PF01058, IPR006137): NADH ubiquinone oxidoreductase, 20 Kd subunit
55 NDUFS8interactor220.64523.835Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
56 NDUFV1interactor320.50277.455Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
57 NDUFV2interactor250.63370.6922Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
58 NDUFV3interactor150.71422.223DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NDUFV3 (PF15880, IPR026193): NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
59 NTRK1oncoprotein360.148838.785I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
60 NUP188interactor201.072Nup188 (PF10487, IPR018864): Nucleoporin subcomplex protein binding to Pom34
Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205
61 OGDHinteractor60.7332.272E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
2-oxogl_dehyd_N (PF16078, IPR032106): 2-oxoglutarate dehydrogenase N-terminus
OxoGdeHyase_C (PF16870, IPR031717): 2-oxoglutarate dehydrogenase C-terminal
62 PARK2suppressor210.289124.478IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
63 PMS1oncoprotein41.0000DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
64 PRPHinteractor100Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
65 PRRT2interactor30.6670.182CD225 (PF04505, IPR007593): Interferon-induced transmembrane protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
66 RBPMSprotein found in more fusions200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
67 RPL14interactor80.64319.186KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
68 RPL23interactor80.64315.329Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
69 RPS14interactor90.47241.797Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
70 RPS2interactor130.39772.800Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
71 SDHBsuppressor140.60413.153Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
72 SLC25A5interactor100.44430.389Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
73 SORT1interactor40.6676.046Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
74 SYNCRIPinteractor110.27377.347RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
75 TOMM20interactor60.40042.315RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
76 TP53suppressor100.33337.452DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
77 UBCprotein found in more fusions200.298210.267ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78 UBE2G2interactor60.40022.746UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
79 UQCRBinteractor220.38190.427UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
80 UQCRC2oncoprotein220.51546.433Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
81 UQCRHinteractor40.6670.422Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
82 VAPAinteractor310.387226.437DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
83 VDAC1interactor220.50258.423Porin_3 (PF01459, IPR027246): Eukaryotic porin
84 VDAC2interactor220.52442.596Porin_3 (PF01459, IPR027246): Eukaryotic porin
85 VDAC3protein found in more fusions200.47950.294Porin_3 (PF01459, IPR027246): Eukaryotic porin
86 XPO1interactor40.5006.395CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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