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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NDUFS4, PLEK (from a repository: Sun Aug 18 11:59:33 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)76
The number (and %) of the onco-proteins8 (10.53 %)
The number (and %) of the tumor suppressors2 (2.63 %)
Total number of binary PPIs (saturation %)551 (19.33 %)
The number (and %) of affected PPIs74 (13.43 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI14.263
Assortativity coefficient-0.2191
The network average Clustering coefficient0.584
The number (and %) of a zero Clustering coefficients5 (6.58 %)
The number (and %) of a zero Betweenness Centrality9 (11.84 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NDUFS4,PLEK All fusions
Proteins found in more fusions APP (see 5 fusions); ATP1A1/VDAC3 (see 2 fusions); PARK2 (see 1 fusions); NDUFS3 (see 2 fusions); ALDOA (see 2 fusions); ATP5A1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NDUFS4parental protein730.1782748.431ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
2 PLEKparental protein100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PH (PF00169, IPR001849, SM00233): PH domain
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
3 ABCD3interactor50.8000.201ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 ALDOAprotein found in more fusions40.6671.000Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
5 ALDOCinteractor21.0000Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
6 APPprotein found in more fusions160.36245.967APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ATAD3Ainteractor60.6001.662AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
8 ATP1A1protein found in more fusions120.6823.991Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9 ATP2A2interactor31.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10 ATP5A1protein found in more fusions140.7185.014ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
11 ATP5C1interactor160.61711.681ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
12 ATP5F1interactor190.49137.027Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
13 ATP5POinteractor180.56918.632OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
14 ATP6V0D1interactor180.47737.593vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
15 CACNA2D1interactor100dCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
16 COX15interactor70.7625.968COX15-CtaA (PF02628, IPR003780): Cytochrome oxidase assembly protein
Peptidase_S3 (PF00944, IPR000930): Alphavirus core protein
17 COX4I1interactor130.55117.135COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
18 COX6B1interactor100.6943.783COX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIb
19 COX7A2Linteractor50.7000.700COX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII
20 CYC1interactor200.36392.101Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
21 DLATinteractor50.6001.7302-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
Stm1_N (PF09598, IPR019084): Stm1
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
22 DNAJC30interactor40.5001.367DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
23 FUBP1oncoprotein30.6670.667DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
24 FUBP3interactor30.6670.667DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
25 GOLT1Binteractor310.443107.784Got1 (PF04178, IPR007305): Got1/Sft2-like family
26 M6PRinteractor21.0000Man-6-P_recep (PF02157, IPR028927): Mannose-6-phosphate receptor
27 MARC1interactor50.4006.222MOSC (PF03473, IPR005302): MOSC domain
MOSC_N (PF03476, IPR005303): MOSC N-terminal beta barrel domain
28 MGST3interactor31.0000MAPEG (PF01124, IPR001129): MAPEG family
29 MRPL15interactor90.333305.000Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
30 MT-ND5interactor90.9720.083NADH5_C (PF06455, IPR010934): NADH dehydrogenase subunit 5 C-terminus
Proton_antipo_M (PF00361, IPR001750): Proton-conducting membrane transporter
Proton_antipo_N (PF00662, IPR001516): NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
31 ND1interactor80.9640.083NA
32 ND4interactor60.9330.083NA
33 NDUFA11interactor210.66716.0377kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
34 NDUFA12interactor350.455179.153NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
35 NDUFA13interactor140.8682.273GRIM-19 (PF06212, IPR009346): GRIM-19 protein
36 NDUFA2interactor170.64713.567L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
37 NDUFA4interactor330.433108.283B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
38 NDUFA7interactor130.61512.167CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
39 NDUFA8interactor280.49754.933CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
40 NDUFA9interactor330.50277.442Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
41 NDUFAF3interactor110.7822.378DUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
42 NDUFB10interactor140.65913.278NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
43 NDUFB4interactor170.58138.567NDUF_B4 (PF07225, IPR009866): NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
44 NDUFB5interactor120.8331.923NDUF_B5 (PF09781, IPR019173): NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
45 NDUFB8interactor180.52930.107NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
46 NDUFS1interactor290.53954.555NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
47 NDUFS2interactor230.57755.600Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
48 NDUFS3protein found in more fusions350.46795.947Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
49 NDUFS5interactor280.53755.364Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
50 NDUFS6interactor230.67224.981Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
51 NDUFS7interactor200.7847.676Oxidored_q6 (PF01058, IPR006137): NADH ubiquinone oxidoreductase, 20 Kd subunit
52 NDUFS8interactor220.64522.685Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
53 NDUFV1interactor320.50277.003Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
54 NDUFV2interactor240.68818.3522Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
55 NDUFV3interactor150.71419.725DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NDUFV3 (PF15880, IPR026193): NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
56 NUP188interactor100Nup188 (PF10487, IPR018864): Nucleoporin subcomplex protein binding to Pom34
Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205
57 OGDHinteractor50.7004.222E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
2-oxogl_dehyd_N (PF16078, IPR032106): 2-oxoglutarate dehydrogenase N-terminus
OxoGdeHyase_C (PF16870, IPR031717): 2-oxoglutarate dehydrogenase C-terminal
58 PARK2suppressor180.31666.788IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
59 PRPHinteractor100Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
60 PRRT2interactor30.6670.182CD225 (PF04505, IPR007593): Interferon-induced transmembrane protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
61 RHOUinteractor20148.000Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
62 RPL14interactor60.8001.400KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
63 RPL23interactor70.6673.467Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
64 RPS14interactor70.61910.567Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
65 RPS2interactor100.48924.511Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
66 SDHBsuppressor140.60414.111Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
67 SLC25A5interactor80.5008.856Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
68 TOMM20interactor50.6002.086RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
69 UBE2G2interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
70 UQCRBinteractor220.38183.254UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
71 UQCRC2oncoprotein210.51931.994Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
72 UQCRHinteractor40.6670.422Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
73 VAPAinteractor290.41996.806DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
74 VDAC1interactor200.52131.583Porin_3 (PF01459, IPR027246): Eukaryotic porin
75 VDAC2interactor210.52932.711Porin_3 (PF01459, IPR027246): Eukaryotic porin
76 VDAC3protein found in more fusions180.49024.473Porin_3 (PF01459, IPR027246): Eukaryotic porin

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