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Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)78
The number (and %) of the onco-proteins17 (21.79 %)
The number (and %) of the tumor suppressors8 (10.26 %)
Total number of binary PPIs (saturation %)373 (12.42 %)
The number (and %) of affected PPIs76 (20.38 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI8.872
Assortativity coefficient-0.2785
The network average Clustering coefficient0.436
The number (and %) of a zero Clustering coefficients9 (11.54 %)
The number (and %) of a zero Betweenness Centrality12 (15.38 %)


List of the fusions

PPI for parental proteins: NDUFB7,DRG1 All fusions
Proteins found in more fusions SSX2IP (see 1 fusions); NDUFS3 (see 2 fusions); STAU1 (see 2 fusions); CKAP4 (see 5 fusions); SFN (see 1 fusions); CUL7 (see 2 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 NDUFB7parental protein330.239862.703DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
NDUF_B7 (PF05676, IPR008698): NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
OrfB_IS605 (PF01385, IPR001959): Probable transposase
2 DRG1parental protein430.0992126.030MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TGS (PF02824, IPR004095): TGS domain
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
3 ABL1oncoprotein90.39329.945Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 ATP1B3interactor140.341196.197Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
5 ATP5F1interactor120.42453.088Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
6 ATP6V0D1interactor90.41719.873vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
7 BARD1suppressor60.40025.726BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
8 BRCA1suppressor80.23872.194BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
9 CAND1interactor110.44431.163Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
10 CAND2interactor21.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
11 CAPN1interactor60.33337.085Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12 CAPNS1interactor50.8008.042EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
13 CCDC8interactor100.36192.852Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
14 CD55oncoprotein40.6671.000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
15 CDC5Linteractor120.43665.114OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
16 CKAP4protein found in more fusions120.255170.336DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
17 CLDN1suppressor100PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
18 COILinteractor40.6671.000CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
19 COX4I1interactor90.5837.195COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
20 CUL7protein found in more fusions120.309136.008ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
21 FEN1oncoprotein60.6004.5985_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
22 FN1oncoprotein160.225269.440fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
23 GOLT1Binteractor160.45842.353Got1 (PF04178, IPR007305): Got1/Sft2-like family
24 GRB2oncoprotein90.32153.174SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
25 HAO1interactor100FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
26 HDGFinteractor60.66711.849PWWP (PF00855, IPR000313, SM00293): PWWP domain
27 HECW2interactor40.6672.000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
28 HSPA1Linteractor70.238143.778HSP70 (PF00012, IPR013126): Hsp70 protein
29 IFRD2oncoprotein100IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
30 ITGA4interactor140.385139.152FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
31 KIF23interactor21.0000DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
32 LAMTOR3interactor70.4298.465MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
33 LRRC41interactor30.6671.788LRR_6 (PF13516, IPR001611): Leucine Rich repeat
34 MAKinteractor200Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
35 MAST3interactor208.650DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
36 MLKLinteractor2030.310Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Kinase-like (PF14531, IPR027916): Kinase-like
37 MMGT1interactor80.60715.548MMgT (PF10270, IPR018937): Membrane magnesium transporter
38 MPV17interactor80.50013.453Mpv17_PMP22 (PF04117, IPR007248): Mpv17 / PMP22 family
39 MRPL58interactor90.6395.571RF-1 (PF00472, IPR000352): RF-1 domain
40 NAA15interactor60.46725.320NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
41 NDUFA10interactor100.55674.840dNK (PF01712, IPR002624): Deoxynucleoside kinase
42 NDUFA12interactor150.60029.001NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
43 NDUFA2interactor200.368234.505L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
44 NDUFA4interactor160.52497.318B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
45 NDUFA8interactor100.7119.187CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
46 NDUFA9interactor180.490127.467Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
47 NDUFB10interactor71.0000NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
48 NDUFB9interactor130.56437.049Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
49 NDUFS3protein found in more fusions220.386269.352Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
50 NDUFS5interactor110.70911.360Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
51 NTMT1interactor100Methyltransf_PK (PF05891, IPR008576): AdoMet dependent proline di-methyltransferase
52 NTRK1oncoprotein260.167775.427I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
53 PAXIP1interactor70.38142.755BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
54 PHB2interactor160.275221.312DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
55 PHC2interactor50.5003.327SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
56 PHKG2interactor30.33364.974APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
57 RAB5Concoprotein170.265249.796Ras (PF00071, IPR001806, SM00173): Ras family
58 RAB7Asuppressor90.36135.507Ras (PF00071, IPR001806, SM00173): Ras family
59 RPL10suppressor110.34548.734Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
60 RWDD1interactor21.0000RWD (PF05773, IPR006575, SM00591): RWD domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
61 SFNsuppressor60.60015.09914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
62 SKILsuppressor50.5006.708c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
63 SNW1protein found in more fusions100.361119.128SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
64 SRPK2oncoprotein60.6004.589DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
65 SSX2IPprotein found in more fusions50.5003.666ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
66 STAU1protein found in more fusions160.362143.420dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
67 STK16interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
68 TAL1oncoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
69 TOMM7interactor100Tom7 (PF08038, IPR012621): TOM7 family
70 UBE2Iinteractor60.30067.511UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
71 UQCRC2oncoprotein120.45572.805Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
72 UQCRQinteractor100.51111.925UcrQ (PF02939, IPR004205): UcrQ family
73 VCAM1interactor110.30992.728C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
74 VDAC3interactor100.44447.217Porin_3 (PF01459, IPR027246): Eukaryotic porin
75 WWOXsuppressor30.6671.000adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
76 XPO1interactor150.210173.218CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
77 ZC3H15interactor50.7005.695zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Torus (PF16131, IPR032297): Torus domain
DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
78 ZMPSTE24interactor30.6676.379Peptidase_M48 (PF01435, IPR001915): Peptidase family M48
Peptidase_M48_N (PF16491, IPR032456): CAAX prenyl protease N-terminal, five membrane helices

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