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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NDUFA3, WDR59 (from a repository: Tue Sep 11 03:25:16 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins5 (20.00 %)
The number (and %) of the tumor suppressors2 (8.00 %)
Total number of binary PPIs (saturation %)55 (18.33 %)
The number (and %) of affected PPIs23 (41.82 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.680
Assortativity coefficient-0.4705
The network average Clustering coefficient0.535
The number (and %) of a zero Clustering coefficients7 (28.00 %)
The number (and %) of a zero Betweenness Centrality15 (60.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: WDR59,NDUFA3 All fusions
Proteins found in more fusions EP300 (see 1 fusions); NDUFS3 (see 1 fusions); FAF1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 WDR59parental protein140.176296.333RWD (PF05773, IPR006575, SM00591): RWD domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DZR (PF12773, IPR025874): Double zinc ribbon
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
2 NDUFA3parental protein90.167210.000NADHdh_A3 (PF14987, IPR026626): NADH dehydrogenase 1 alpha subcomplex subunit 3
3 ECSITinteractor51.0000ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
4 EP300oncoprotein31.0000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
5 FAF1protein found in more fusions50.66722.000UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
6 GAL3ST1interactor100Rhabdo_M1 (PF03342, IPR005010): Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)
7 GATSL3interactor31.0000ACT_7 (PF13840, IPR027795): ACT domain
8 HERC2interactor41.0000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
9 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
10 NDUFA8interactor41.0000CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
11 NDUFS3protein found in more fusions60.600270.000Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
12 NPRL2suppressor40.8330.667NPR2 (PF06218, IPR009348): Nitrogen permease regulator 2
13 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
14 NTRK1oncoprotein60.300283.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
15 OLFM4suppressor100DUF1373 (PF07117, IPR009803): Protein of unknown function (DUF1373)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
16 RAE1interactor40.8330.667Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
17 SEC13interactor41.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
18 SEH1Linteractor50.7002.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
19 SLC18A1interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
20 THBS3oncoprotein200EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
21 THTPAinteractor100CYTH (PF01928, IPR023577, SM01118): CYTH domain
22 TIMMDC1interactor41.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
23 TXNDC5interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
24 WDR24interactor80.42914.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
25 WDR5interactor30.66711.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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