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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GPR180, NDUFA3 (from a repository: Sun Aug 25 14:17:56 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins3 (20.00 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)26 (24.76 %)
The number (and %) of affected PPIs13 (50.00 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.800
Assortativity coefficient-0.1183
The network average Clustering coefficient0.251
The number (and %) of a zero Clustering coefficients10 (66.67 %)
The number (and %) of a zero Betweenness Centrality9 (60.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GPR180,NDUFA3 All fusions
Proteins found in more fusions NDUFS3 (see 1 fusions); CLU (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GPR180parental protein4054.000GpcrRhopsn4 (PF10192, IPR019336): Rhodopsin-like GPCR transmembrane domain
2 NDUFA3parental protein90.167108.000NADHdh_A3 (PF14987, IPR026626): NADH dehydrogenase 1 alpha subcomplex subunit 3
3 CLUsuppressor3022.000Clusterin (PF01093, IPR000753): Clusterin
4 ECSITinteractor51.0000ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
5 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 GAL3ST1interactor100Rhabdo_M1 (PF03342, IPR005010): Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)
7 HLA-DPA1interactor2032.000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
8 NDUFA8interactor41.0000CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
9 NDUFS3protein found in more fusions60.60050.000Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
10 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
11 SGCAinteractor100Sarcoglycan_2 (PF05510, IPR008908): Sarcoglycan alpha/epsilon
12 SLC18A1interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
13 THBS3oncoprotein200EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
14 TIMMDC1interactor41.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
15 TMEM17interactor2040.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)

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