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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins14 (28.00 %)
The number (and %) of the tumor suppressors2 (4.00 %)
Total number of binary PPIs (saturation %)182 (14.86 %)
The number (and %) of affected PPIs48 (26.37 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI6.600
Assortativity coefficient-0.2311
The network average Clustering coefficient0.396
The number (and %) of a zero Clustering coefficients14 (28.00 %)
The number (and %) of a zero Betweenness Centrality13 (26.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MYO9A,ALDH7A1 All fusions
Proteins found in more fusions SORD (see 1 fusions); EPS8 (see 1 fusions); APP (see 5 fusions); YWHAG (see 1 fusions); XRCC4 (see 1 fusions); MCM2 (see 1 fusions); MYC (see 2 fusions); YWHAH (see 2 fusions); G6PD (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MYO9Aparental protein110.055289.697CemA (PF03040, IPR004282): CemA family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
AAA_23 (PF13476): AAA domain
CCDC92 (PF14916): Coiled-coil domain of unknown function
2 ALDH7A1parental protein370.1311205.801Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4 APPprotein found in more fusions110.244114.769APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ASNSoncoprotein100.60011.727Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
6 CAPN2interactor51.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CAPNS1interactor120.59116.162EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CATsuppressor90.39358.304Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
9 CDC42oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
10 CEP152interactor30.33311.469bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase
YtxH (PF12732, IPR024623): YtxH-like protein
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
11 CPT2interactor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
12 DDA1interactor40.33312.932DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
13 EIF5interactor120.45534.759CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
14 EPS8oncoprotein3018.922DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
15 ERP44interactor50.50012.432Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
16 FAHD2Ainteractor31.0000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
17 FERMT2interactor80.6797.605FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
18 G6PDprotein found in more fusions120.56433.385G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
19 GLAinteractor40.8331.008Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
20 GOT1interactor3026.123Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
21 HIBCHinteractor100ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
22 HMGB3interactor50.30044.169HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
23 JADE2interactor100PRA-PH (PF01503, IPR021130): Phosphoribosyl-ATP pyrophosphohydrolase
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
zf-RRPl_C4 (PF17026, IPR031502): Putative ribonucleoprotein zinc-finger pf C4 type
24 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
25 KIF2Ainteractor200Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
26 L3HYPDHinteractor100Pro_racemase (PF05544, IPR008794): Proline racemase
27 LDHBinteractor110.48932.544Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
28 MCM2oncoprotein160.200307.329AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
29 MOV10interactor5043.300AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
30 MYConcoprotein60.10054.619HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
31 NXF1interactor5028.902NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
32 PCM1oncoprotein40.16724.327FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
33 PDIA4interactor90.63914.170Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
34 PGDoncoprotein90.38968.6406PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
35 POLR2Minteractor100GCOM2 (PF15328, IPR026213): Putative GRINL1B complex locus protein 2
36 PPIAinteractor40.6676.784Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
37 PPP1CAsuppressor80.57129.599Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38 PPP2R2Binteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
39 PRDX5interactor40.8330.619Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
40 SCPEP1interactor60.8670.836Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
41 SKAP1interactor306.751PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
42 SORDprotein found in more fusions70.5339.828ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
43 STK24interactor80.7142.300DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
44 TBCBinteractor120.59117.089CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
45 UBA5interactor306.165Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
46 XRCC4protein found in more fusions200XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
47 YWHAEoncoprotein150.45797.99814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
48 YWHAGprotein found in more fusions110.62221.13514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
49 YWHAHprotein found in more fusions150.451122.82614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
50 YWHAQinteractor120.48590.97514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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