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Fusion ID: Protein names:	4649 501
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Visualization interactions

Cytoscape Web for: parental proteins MYO9A, ALDH7A1 (from a repository: Sun Aug 11 02:14:59 2019)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	50
The number (and %) of the onco-proteins	14 (28.00 %)
The number (and %) of the tumor suppressors	2 (4.00 %)
Total number of binary PPIs (saturation %)	182 (14.86 %)
The number (and %) of affected PPIs	48 (26.37 %)
The number of possible different fusions	10
PPI diameter	5
PPI radius	3
The average degree of PPI	6.600
Assortativity coefficient	-0.2311
The network average Clustering coefficient	0.396
The number (and %) of a zero Clustering coefficients	14 (28.00 %)
The number (and %) of a zero Betweenness Centrality	13 (26.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MYO9A,ALDH7A1	All fusions
Proteins found in more fusions	SORD (see 1 fusions); EPS8 (see 1 fusions); APP (see 5 fusions); YWHAG (see 1 fusions); XRCC4 (see 1 fusions); MCM2 (see 1 fusions); MYC (see 2 fusions); YWHAH (see 2 fusions); G6PD (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MYO9A	parental protein	11	0.055	289.697	CemA (PF03040, IPR004282): CemA family IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain AAA_23 (PF13476): AAA domain CCDC92 (PF14916): Coiled-coil domain of unknown function
2	ALDH7A1	parental protein	37	0.131	1205.801	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3	ABAT	interactor	2	1.000	0	Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4	APP	protein found in more fusions	11	0.244	114.769	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5	ASNS	oncoprotein	10	0.600	11.727	Asn_synthase (PF00733, IPR001962): Asparagine synthase GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
6	CAPN2	interactor	5	1.000	0	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7	CAPNS1	interactor	12	0.591	16.162	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8	CAT	suppressor	9	0.393	58.304	Catalase (PF00199, IPR011614, SM01060): Catalase Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
9	CDC42	oncoprotein	3	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
10	CEP152	interactor	3	0.333	11.469	bZIP_1 (PF00170, IPR004827): bZIP transcription factor CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18 FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase YtxH (PF12732, IPR024623): YtxH-like protein ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
11	CPT2	interactor	1	0	0	Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
12	DDA1	interactor	4	0.333	12.932	DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
13	EIF5	interactor	12	0.455	34.759	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
14	EPS8	oncoprotein	3	0	18.922	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
15	ERP44	interactor	5	0.500	12.432	Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
16	FAHD2A	interactor	3	1.000	0	FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
17	FERMT2	interactor	8	0.679	7.605	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
18	G6PD	protein found in more fusions	12	0.564	33.385	G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
19	GLA	interactor	4	0.833	1.008	Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
20	GOT1	interactor	3	0	26.123	Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
21	HIBCH	interactor	1	0	0	ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
22	HMGB3	interactor	5	0.300	44.169	HMG_box_2 (PF09011, IPR009071): HMG-box domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
23	JADE2	interactor	1	0	0	PRA-PH (PF01503, IPR021130): Phosphoribosyl-ATP pyrophosphohydrolase EPL1 (PF10513, IPR019542): Enhancer of polycomb-like PHD_2 (PF13831): PHD-finger zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain zf-RRPl_C4 (PF17026, IPR031502): Putative ribonucleoprotein zinc-finger pf C4 type
24	KBTBD7	interactor	1	0	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_2 (PF07646, IPR011498): Kelch motif Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_6 (PF13964): Kelch motif
25	KIF2A	interactor	2	0	0	Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain AAA_23 (PF13476): AAA domain CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
26	L3HYPDH	interactor	1	0	0	Pro_racemase (PF05544, IPR008794): Proline racemase
27	LDHB	interactor	11	0.489	32.544	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
28	MCM2	oncoprotein	16	0.200	307.329	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
29	MOV10	interactor	5	0	43.300	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
30	MYC	oncoprotein	6	0.100	54.619	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
31	NXF1	interactor	5	0	28.902	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
32	PCM1	oncoprotein	4	0.167	24.327	FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus FUSC (PF04632, IPR006726): Fusaric acid resistance protein family IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family AAA_23 (PF13476): AAA domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
33	PDIA4	interactor	9	0.639	14.170	Calsequestrin (PF01216, IPR001393): Calsequestrin Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain FAM176 (PF14851): FAM176 family
34	PGD	oncoprotein	9	0.389	68.640	6PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
35	POLR2M	interactor	1	0	0	GCOM2 (PF15328, IPR026213): Putative GRINL1B complex locus protein 2
36	PPIA	interactor	4	0.667	6.784	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
37	PPP1CA	suppressor	8	0.571	29.599	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38	PPP2R2B	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
39	PRDX5	interactor	4	0.833	0.619	Redoxin (PF08534, IPR013740): Redoxin NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
40	SCPEP1	interactor	6	0.867	0.836	Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
41	SKAP1	interactor	3	0	6.751	PH (PF00169, IPR001849, SM00233): PH domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
42	SORD	protein found in more fusions	7	0.533	9.828	ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
43	STK24	interactor	8	0.714	2.300	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain
44	TBCB	interactor	12	0.591	17.089	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
45	UBA5	interactor	3	0	6.165	Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat ThiF (PF00899, IPR000594): ThiF family
46	XRCC4	protein found in more fusions	2	0	0	XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
47	YWHAE	oncoprotein	15	0.457	97.998	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
48	YWHAG	protein found in more fusions	11	0.622	21.135	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
49	YWHAH	protein found in more fusions	15	0.451	122.826	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
50	YWHAQ	interactor	12	0.485	90.975	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors