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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins9 (15.79 %)
The number (and %) of the tumor suppressors8 (14.04 %)
Total number of binary PPIs (saturation %)168 (10.53 %)
The number (and %) of affected PPIs57 (33.93 %)
The number of possible different fusions9
PPI diameter4
PPI radius2
The average degree of PPI5.368
Assortativity coefficient-0.3351
The network average Clustering coefficient0.484
The number (and %) of a zero Clustering coefficients14 (24.56 %)
The number (and %) of a zero Betweenness Centrality19 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ND4,MYH11 All fusions
Proteins found in more fusions SFN (see 1 fusions); NDUFS3 (see 2 fusions); SHC1 (see 1 fusions); ACTB (see 7 fusions); GRB2 (see 1 fusions); RPA1 (see 1 fusions); APC (see 1 fusions); SP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ND4parental protein130.295697.784NA
2 MYH11parental protein440.0712091.031IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
3 ACTA2interactor70.47610.299Actin (PF00022, IPR004000, SM00268): Actin
4 ACTBoncoprotein150.27596.619Actin (PF00022, IPR004000, SM00268): Actin
5 ACTR3interactor60.6674.321Actin (PF00022, IPR004000, SM00268): Actin
6 APCsuppressor70.400276.426APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
7 ARPC5interactor50.6002.233P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
8 ARPC5Linteractor50.8001.300P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
9 ASTE1interactor100XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
XPG_I_2 (PF12813): XPG domain containing
10 ATMsuppressor80.190158.776FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
11 C4BPAinteractor100Toxin_13 (PF07822, IPR012497): Neurotoxin B-IV-like protein
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
12 CAPZBinteractor50.6006.200Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
13 CGNinteractor30.6670.667DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Filament (PF00038, IPR001664): Intermediate filament protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
DUF4559 (PF15112, IPR027897): Domain of unknown function (DUF4559)
Leu_zip (PF15294): Leucine zipper
14 DAXXoncoprotein3019.390Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
15 DSTNinteractor21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
16 ECSITinteractor60.9000.286ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
17 EIF3Aoncoprotein21.0000DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
PCI (PF01399, IPR000717, SM00088): PCI domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
18 FAM96Ainteractor100DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
19 FBXO25suppressor30.6670.667Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
20 FLNAsuppressor150.286193.551CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
21 GRB2oncoprotein80.429326.200SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
22 INF2interactor21.0000Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
23 LGR4interactor40.6671.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 LIG4interactor30.33329.572APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
25 LRRC59interactor21.0000Hid1 (PF12722): High-temperature-induced dauer-formation protein
LRR_8 (PF13855, IPR001611): Leucine rich repeat
DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
26 MED4interactor50.7004.167Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
27 MYL6interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
28 MYO1Einteractor70.61910.130IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
29 MYO5Ainteractor40.6672.333DIL (PF01843, IPR018444, SM01132): DIL domain
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SOGA (PF11365, IPR027881): Protein SOGA
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
CYTL1 (PF15153, IPR029253): Cytokine-like protein 1
30 MYOCinteractor40.6670.333IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
31 NDUFA11interactor60.9330.2867kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
32 NDUFA8interactor80.57143.280CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
33 NDUFS3protein found in more fusions90.7503.286Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
34 NDUFS4interactor60.9330.286ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
35 NDUFS5interactor70.7143.000Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
36 NDUFS6interactor60.9330.286Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
37 NKX3-1suppressor2021.745Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
38 OVCA2suppressor100FSH1 (PF03959, IPR005645): Serine hydrolase (FSH1)
39 PLBD2interactor100Phospholip_B (PF04916, IPR007000): Phospholipase B
DUF3693 (PF12472, IPR021096): Phage related protein
40 POC1Ainteractor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
41 RAD51interactor60.50029.713Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
42 RALBP1interactor100DDHD (PF02862, IPR004177, SM01127): DDHD domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SlyX (PF04102, IPR007236): SlyX
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
43 RPA1suppressor120.49170.306Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
44 RPA2oncoprotein100.51166.402RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
45 RPA3interactor110.51116.550Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
46 RWDD2Binteractor100DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115)
RWD (PF05773, IPR006575, SM00591): RWD domain
47 SFNsuppressor60.50014.53614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
48 SHC1oncoprotein41.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
49 SLX1Binteractor100GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
50 SP1protein found in more fusions60.30082.071zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
51 SVILinteractor31.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
52 TBC1D31interactor21.0000Neisseria_PilC (PF05567, IPR008707): Neisseria PilC beta-propeller domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nbas_N (PF15492, IPR029145): Neuroblastoma-amplified sequence, N terminal
53 TIMMDC1interactor50.9000.286Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
54 TMEM189interactor100MARVEL (PF01284, IPR008253): Membrane-associating domain
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
55 UBXN2Ainteractor100SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
56 YWHAEoncoprotein50.6009.28314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
57 YWHAQinteractor70.47611.40014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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