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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins INO80B-WBP1, MYD88 (from a repository: Thu Aug 1 21:24:40 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins20 (34.48 %)
The number (and %) of the tumor suppressors10 (17.24 %)
Total number of binary PPIs (saturation %)214 (12.95 %)
The number (and %) of affected PPIs57 (26.64 %)
The number of possible different fusions12
PPI diameter2
PPI radiusinf
The average degree of PPI6.414
Assortativity coefficient-0.2910
The network average Clustering coefficient0.620
The number (and %) of a zero Clustering coefficients6 (10.34 %)
The number (and %) of a zero Betweenness Centrality23 (39.66 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MYD88,INO80B-WBP1 All fusions
Proteins found in more fusions PFKL (see 2 fusions); SIAH2 (see 1 fusions); TRAF6 (see 1 fusions); MAP3K7 (see 7 fusions); SYK (see 1 fusions); SQSTM1 (see 5 fusions); RAC1 (see 2 fusions); PRDX1 (see 1 fusions); CBLB (see 4 fusions); SMAD3 (see 3 fusions); IRF7 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MYD88parental protein570.0842282.639Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
2 INO80B-WBP1interactor000NA
3 BST2oncoprotein21.0000DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
4 BTKsuppressor80.6193.700BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 CBLBoncoprotein60.7000.868Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 CD93interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Plasmod_Pvs28 (PF06247, IPR010423): Pvs28 EGF domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
7 CISHinteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
SOCS_box (PF07525, IPR001496): SOCS box
8 CYLDsuppressor70.6194.733CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
9 FADDsuppressor40.5001.833Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
10 FLIIoncoprotein30.6671.000Gelsolin (PF00626, IPR007123): Gelsolin repeat
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
11 HDAC6oncoprotein70.4006.567Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
12 IKBKEinteractor60.8001.167IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
13 IKBKGinteractor140.41033.448CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
14 IL1R1interactor70.8102.167TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
15 IL1RAPinteractor50.6003.333ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
16 IL1RL1interactor41.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
17 IRAK1interactor230.281110.705Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
18 IRAK2oncoprotein100.6228.767Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
19 IRAK3interactor51.0000Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
20 IRAK4interactor130.50019.500Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
21 IRF4suppressor31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
22 IRF5suppressor31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
23 IRF7protein found in more fusions60.5002.852IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
24 LRRFIP1oncoprotein21.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
LRRFIP (PF09738, IPR019139): LRRFIP family
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
Coilin_N (PF15862, IPR031722): Coilin N-terminus
25 LRRFIP2interactor21.0000TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
LRRFIP (PF09738, IPR019139): LRRFIP family
26 MALsuppressor21.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
27 MAP3K7oncoprotein140.34636.368Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
28 MBIPinteractor31.0000DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
29 MDM2oncoprotein40.6670.400Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
30 PELI1interactor70.7624.167Pellino (PF04710, IPR006800): Pellino
31 PFKLprotein found in more fusions31.0000PFK (PF00365, IPR000023): Phosphofructokinase
32 POLR1Cinteractor21.0000RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
33 PRDX1oncoprotein31.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
34 RAC1oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
35 SARM1interactor41.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Carb_kinase (PF01256, IPR000631): Carbohydrate kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
HEAT_2 (PF13646): HEAT repeats
TIR_2 (PF13676, IPR000157): TIR domain
36 SASH1suppressor50.9000.333PGA2 (PF07543, IPR011431): Protein trafficking PGA2
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
37 SIAH1suppressor40.6671.000Sina (PF03145, IPR018121): Seven in absentia protein family
38 SIAH2oncoprotein31.0000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
39 SMAD3oncoprotein80.2867.219MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
40 SMAD6interactor40.5001.567MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
41 SMURF1interactor70.3335.701C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
42 SPOPsuppressor40.6670.500BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
43 SQSTM1oncoprotein80.5714.819PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
44 STAP2interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
45 SYKsuppressor110.51112.920Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
46 TIRAPinteractor110.53311.538TIR_2 (PF13676, IPR000157): TIR domain
47 TLR2interactor41.0000LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
48 TLR3interactor60.7332.248LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
49 TLR4interactor90.5288.687LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
50 TLR5interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
51 TLR7interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
52 TLR9interactor60.6671.534LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
53 TNFRSF13Boncoprotein50.7001.015TACI-CRD2 (PF09305, IPR015384): TACI, cysteine-rich domain
54 TNIP1interactor51.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
55 TRAF3oncoprotein140.29536.052ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
56 TRAF6protein found in more fusions270.218186.052SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
57 TXNoncoprotein30.6671.000Thioredoxin (PF00085, IPR013766): Thioredoxin
58 USP7oncoprotein90.32113.601MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal

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