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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MXI1, TMX1 (from a repository: Sat Mar 4 18:49:50 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins9 (19.57 %)
The number (and %) of the tumor suppressors4 (8.70 %)
Total number of binary PPIs (saturation %)117 (11.30 %)
The number (and %) of affected PPIs44 (37.61 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI4.348
Assortativity coefficient-0.3777
The network average Clustering coefficient0.507
The number (and %) of a zero Clustering coefficients12 (26.09 %)
The number (and %) of a zero Betweenness Centrality24 (52.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TMX1,MXI1 All fusions
Proteins found in more fusions LYN (see 2 fusions); APP (see 4 fusions); EWSR1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TMX1parental protein270.091926.194OST3_OST6 (PF04756, IPR021149): OST3 / OST6 family, transporter family
Thioredoxin (PF00085, IPR013766): Thioredoxin
FAM176 (PF14851): FAM176 family
2 MXI1parental protein170.132779.611EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
3 ADRB2interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 APPprotein found in more fusions90.179645.692APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATF2oncoprotein70.533124.978bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
6 BUB1Boncoprotein31.0000Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
7 CALCOCO2interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
8 CDC20oncoprotein40.66721.769WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 CYSTM1interactor21.0000CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
10 ELAVL1oncoprotein110.267194.141RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 ENTPD5interactor100GDA1_CD39 (PF01150, IPR000407): GDA1/CD39 (nucleoside phosphatase) family
12 EPHX1interactor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
13 EVC2interactor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
14 EWSR1oncoprotein60.40013.849RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
15 FASsuppressor200Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
16 FBXW11interactor60.200278.658WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
17 H2AFXsuppressor30.6670.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
18 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
19 KRTAP10-3interactor70.8671.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
20 KRTAP10-5interactor51.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
21 KRTAP10-7interactor80.667109.846Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
22 KRTAP10-8interactor61.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
23 KRTAP10-9interactor61.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
24 LMAN1interactor90.361224.688Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
25 LYNoncoprotein40.6671.400Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26 LYPD6interactor21.0000UPAR_LY6_2 (PF16975): Ly6/PLAUR domain-containing protein 6, Lypd6
27 MAXsuppressor31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
28 NDUFB11interactor21.0000ESSS (PF10183, IPR019329): ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
29 NOTCH2NLinteractor60.8671.000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
30 RPL23AP32interactor100NA
31 RPL7interactor100Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
32 SIN3Binteractor100Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
33 SMC3oncoprotein100SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
34 SPI1suppressor100Ets (PF00178, IPR000418, SM00413): Ets-domain
p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
35 SSR1interactor60.6006.317TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
36 SULT2A1interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
37 TCTN1interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
38 TCTN2interactor40.66710.803DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
39 TCTN3interactor31.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
40 TMEM17interactor30.6671.289Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
41 TMEM216interactor50.70082.136Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
42 TXNoncoprotein21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
43 UPF1interactor30.33381.969UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
44 VDAC1interactor60.6005.979Porin_3 (PF01459, IPR027246): Eukaryotic porin
45 VDAC2interactor70.476143.347Porin_3 (PF01459, IPR027246): Eukaryotic porin
46 VDAC3interactor50.7002.667Porin_3 (PF01459, IPR027246): Eukaryotic porin

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