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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MXI1, REEP1 (from a repository: Fri Jul 12 19:43:58 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins6 (28.57 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)51 (24.29 %)
The number (and %) of affected PPIs19 (37.25 %)
The number of possible different fusions3
PPI diameter4
PPI radius2
The average degree of PPI3.714
Assortativity coefficient-0.3889
The network average Clustering coefficient0.424
The number (and %) of a zero Clustering coefficients9 (42.86 %)
The number (and %) of a zero Betweenness Centrality11 (52.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: REEP1,MXI1 All fusions
Proteins found in more fusions APP (see 5 fusions); BUB1B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 REEP1parental protein201.000TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
2 MXI1parental protein170.132301.000EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
3 APPprotein found in more fusions50.5009.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BUB1Boncoprotein31.0000Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
5 CALCOCO2interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
6 CDC20oncoprotein40.6671.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
7 ELAVL1oncoprotein3018.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 ENTPD5interactor100GDA1_CD39 (PF01150, IPR000407): GDA1/CD39 (nucleoside phosphatase) family
9 FBXW11interactor60.200104.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
10 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
11 KRTAP10-3interactor70.8671.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
12 KRTAP10-5interactor51.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
13 KRTAP10-7interactor80.6676.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
14 KRTAP10-8interactor61.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
15 KRTAP10-9interactor61.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
16 MAXsuppressor31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
17 NOTCH2NLinteractor60.8671.000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
18 RPL23AP32interactor100NA
19 SIN3Binteractor100Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
20 SMC3oncoprotein100SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
21 YWHAEoncoprotein2018.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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