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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IGKC, MT-ND4L (from a repository: Thu Aug 1 16:37:21 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins4 (16.67 %)
The number (and %) of the tumor suppressors4 (16.67 %)
Total number of binary PPIs (saturation %)39 (14.13 %)
The number (and %) of affected PPIs22 (56.41 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI2.667
Assortativity coefficient-0.4420
The network average Clustering coefficient0.387
The number (and %) of a zero Clustering coefficients12 (50.00 %)
The number (and %) of a zero Betweenness Centrality17 (70.83 %)


List of the fusions

PPI for parental proteins: IGKC,MT-ND4L All fusions
Proteins found in more fusions EGFR (see 2 fusions); STAT1 (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 IGKCparental protein210.043471.000DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
2 MT-ND4Lparental protein100Oxidored_q2 (PF00420, IPR001133): NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
3 ALBinteractor30.6671.000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 ALDH2oncoprotein21.0000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
5 APOA1interactor60.4006.000ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
6 ASCC1interactor100AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
7 BAG3oncoprotein31.0000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 CA8interactor21.0000Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
9 CDK5RAP3interactor100DUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
10 DDX19Binteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 EEDsuppressor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
12 EGFRoncoprotein3084.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 GTF2Binteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
14 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
15 ILF3oncoprotein30.6671.000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
16 MLH1suppressor100DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
17 MYOCinteractor200IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
18 PES1interactor31.0000Pescadillo_N (PF06732, IPR010613): Pescadillo N-terminus
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
19 PLK2suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
20 RRP1Binteractor40.5003.000Nop52 (PF05997, IPR010301): Nucleolar protein,Nop52
21 SMARCD1interactor100ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
DivIC (PF04977, IPR007060): Septum formation initiator
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
22 STAT1suppressor3044.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
23 UGT1A10interactor100UDPGT (PF00201, IPR002213): UDP-glucoronosyl and UDP-glucosyl transferase
24 ZSCAN20interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Glyco_trans_1_2 (PF13524): Glycosyl transferases group 1
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

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