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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LSM7, ND4 (from a repository: Wed Oct 2 15:22:56 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins11 (20.37 %)
The number (and %) of the tumor suppressors6 (11.11 %)
Total number of binary PPIs (saturation %)181 (12.65 %)
The number (and %) of affected PPIs52 (28.73 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI6.148
Assortativity coefficient-0.3038
The network average Clustering coefficient0.493
The number (and %) of a zero Clustering coefficients18 (33.33 %)
The number (and %) of a zero Betweenness Centrality22 (40.74 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LSM7,ND4 All fusions
Proteins found in more fusions PFKM (see 1 fusions); NDUFS3 (see 2 fusions); SART3 (see 2 fusions); GRB2 (see 1 fusions); EXOSC6 (see 1 fusions); APC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LSM7parental protein390.1191726.794LSM (PF01423, IPR001163): LSM domain
2 ND4parental protein130.2951052.286NA
3 APCsuppressor200APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4 ATMsuppressor40.6671.000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5 DDIT4Linteractor100RTP801_C (PF07809, IPR012918): RTP801 C-terminal region
6 ECSITinteractor60.9000.286ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
7 EPHA2suppressor30210.800fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
8 EXOSC6protein found in more fusions40.6671.000RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
9 EXOSC8interactor31.0000RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
10 FKBP4interactor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
11 GRB2oncoprotein501043.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
12 KLC2interactor41.0000TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
13 LDB1oncoprotein100LIM_bind (PF01803): LIM-domain binding protein
14 LIG4interactor21.0000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
15 LSM2interactor170.52959.353LSM (PF01423, IPR001163): LSM domain
16 LSM3interactor130.55116.529LSM (PF01423, IPR001163): LSM domain
17 LSM4interactor170.42698.365LSM (PF01423, IPR001163): LSM domain
18 LSM5interactor80.7862.130LSM (PF01423, IPR001163): LSM domain
19 LSM6interactor160.46775.065LSM (PF01423, IPR001163): LSM domain
20 LSM8interactor100.64411.417LSM (PF01423, IPR001163): LSM domain
21 MEPCEinteractor100.60021.679Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
22 MYH13interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
23 NAA38interactor70.8571.500LSM (PF01423, IPR001163): LSM domain
24 NDUFA11interactor60.9330.2867kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
25 NDUFA8interactor80.5719.000CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
26 NDUFS3protein found in more fusions90.7503.286Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
27 NDUFS4interactor60.9330.286ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
28 NDUFS5interactor70.7143.000Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
29 NDUFS6interactor60.9330.286Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
30 NKX3-1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31 NMD3interactor100DUF1816 (PF08846, IPR014945): Domain of unknown function (DUF1816)
NMD3 (PF04981, IPR007064): NMD3 family
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
32 NPY1Roncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
PLAC8 (PF04749, IPR006461): PLAC8 family
33 PFKMprotein found in more fusions200PFK (PF00365, IPR000023): Phosphofructokinase
34 PKN2interactor61.0000C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
35 PPP2R5Csuppressor21.0000B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
36 PRPF4interactor90.9290.486PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
37 RAB29oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
38 RASSF5suppressor200RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
39 RFX5oncoprotein100RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
RFX5_DNA_bdg (PF14621, IPR029298): RFX5 DNA-binding domain
40 SART3protein found in more fusions90.9290.486CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
Lsm_interact (PF05391, IPR008669): Lsm interaction motif
Phage_GPD (PF05954): Phage late control gene D protein (GPD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
MRI (PF15325, IPR028278): Modulator of retrovirus infection
LSM_int_assoc (PF16605): LSM-interacting associated unstructured
41 SGTAinteractor21.0000TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
42 SMN1interactor110.7337.780SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
43 SNRPD1interactor90.75010.179API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
LSM (PF01423, IPR001163): LSM domain
44 SNRPD2interactor100.644543.066LSM (PF01423, IPR001163): LSM domain
45 SNRPD3interactor100.7785.456LSM (PF01423, IPR001163): LSM domain
46 SNRPEinteractor100.73310.132LSM (PF01423, IPR001163): LSM domain
47 SNRPFinteractor90.6946.944LSM (PF01423, IPR001163): LSM domain
48 TACC1oncoprotein100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
49 TIMMDC1interactor50.9000.286Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
50 TXNL1interactor100PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
51 USP4oncoprotein100.8331.905UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
52 WDR44interactor30.333283.933CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
53 ZBTB8Binteractor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
54 ZSCAN26interactor100C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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