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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins5 (12.82 %)
The number (and %) of the tumor suppressors6 (15.38 %)
Total number of binary PPIs (saturation %)117 (15.79 %)
The number (and %) of affected PPIs44 (37.61 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI5.590
Assortativity coefficient-0.4558
The network average Clustering coefficient0.450
The number (and %) of a zero Clustering coefficients15 (38.46 %)
The number (and %) of a zero Betweenness Centrality20 (51.28 %)


List of the fusions

PPI for parental proteins: ND1,ND4 All fusions
Proteins found in more fusions NDUFS3 (see 2 fusions); APC (see 1 fusions); GRB2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ND1parental protein310.092989.837NA
2 ND4parental protein130.295239.185NA
3 APCsuppressor200APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4 ATMsuppressor70.13337.067FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5 BARD1suppressor31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
6 BRCA1suppressor40.3339.343BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
7 BTN2A1interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3169 (PF11368, IPR021509): Protein of unknown function (DUF3169)
DUF3213 (PF11491, IPR021583): Protein of unknown function (DUF3213)
Ig_3 (PF13927): Immunoglobulin domain
8 DHDDSinteractor100DUF480 (PF04337, IPR007432): Protein of unknown function, DUF480
Prenyltransf (PF01255, IPR001441): Putative undecaprenyl diphosphate synthase
9 ECSITinteractor110.44465.782ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
10 EDNRAinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
11 GRB2oncoprotein200SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
12 KLK5oncoprotein100Trypsin (PF00089, IPR001254, SM00020): Trypsin
13 KLK8interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
14 LIG4interactor30.33322.200APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
15 LPAR1oncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
16 LPAR6interactor206.3437tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1
17 MEOX2interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
18 NAMPTinteractor100NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
19 NDUFA11interactor100.8894.9297kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
20 NDUFA12interactor110.85510.861NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
21 NDUFA8interactor130.62857.122CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
22 NDUFS1interactor110.83612.413NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
23 NDUFS3protein found in more fusions150.65956.175Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
24 NDUFS4interactor110.85529.909ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
25 NDUFS5interactor120.72734.437Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
26 NDUFS6interactor100.8894.929Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
27 NDUFV1interactor110.85510.861Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
28 NDUFV2interactor100.9339.2902Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
29 NKX3-1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
30 P2RY12interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
31 P2RY8oncoprotein206.3437tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
32 PARK7suppressor31.0000DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
33 PAXIP1interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
34 RPL13Ainteractor21.0000Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
35 RPL6interactor21.0000Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
36 TIMMDC1interactor80.78618.976Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
37 TNFSF11interactor100TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
DUF2735 (PF10931, IPR021232): Protein of unknown function (DUF2735)
38 TSTinteractor100Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
39 VSIG4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain

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