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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MRPL13, ND4 (from a repository: Sat Sep 7 02:39:50 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)72
The number (and %) of the onco-proteins9 (12.50 %)
The number (and %) of the tumor suppressors3 (4.17 %)
Total number of binary PPIs (saturation %)605 (23.67 %)
The number (and %) of affected PPIs71 (11.74 %)
The number of possible different fusions10
PPI diameter4
PPI radius2
The average degree of PPI16.361
Assortativity coefficient0.0130
The network average Clustering coefficient0.553
The number (and %) of a zero Clustering coefficients6 (8.33 %)
The number (and %) of a zero Betweenness Centrality7 (9.72 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MRPL13,ND4 All fusions
Proteins found in more fusions CUL7 (see 2 fusions); GRB2 (see 1 fusions); PPM1K (see 1 fusions); NDUFS3 (see 2 fusions); OXA1L (see 1 fusions); LYRM2 (see 1 fusions); APC (see 1 fusions); FN1/RPL6 (see 1 fusions); COQ4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MRPL13parental protein580.2871485.220Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
2 ND4parental protein130.295241.470NA
3 APCsuppressor4026.275APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4 ATMsuppressor40.6671.143FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5 C6orf203interactor81.0000Bystin (PF05291, IPR007955): Bystin
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
6 COQ2interactor200UbiA (PF01040, IPR000537): UbiA prenyltransferase family
7 COQ4protein found in more fusions50.5002.125Coq4 (PF05019, IPR007715): Coenzyme Q (ubiquinone) biosynthesis protein Coq4
8 COQ6interactor31.0000FAD_binding_3 (PF01494, IPR002938): FAD binding domain
Lycopene_cycl (PF05834, IPR008671): Lycopene cyclase protein
9 CUL7protein found in more fusions90.60712.696ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
10 DHRS4interactor40.6671.581adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
11 DLDinteractor90.44410.831Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
12 ECSITinteractor70.8001.853ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
13 FBXW11interactor120.41848.544WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
14 FN1oncoprotein100.42257.714fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
15 GRB2oncoprotein40.33318.249SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
16 HNRNPA1interactor320.523240.065RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
17 HNRNPUinteractor190.491105.637CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
18 LIG4interactor40.16787.363APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
19 LYRM2protein found in more fusions200Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
20 MOV10interactor180.301129.566AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
21 MPV17interactor90.33335.425Mpv17_PMP22 (PF04117, IPR007248): Mpv17 / PMP22 family
22 MRPL1interactor310.61964.584CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
23 MRPL10interactor180.75210.373Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
24 MRPL11interactor200.70021.172Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
25 MRPL14interactor180.8178.033Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
RTT107_BRCT_6 (PF16771, IPR031906): Regulator of Ty1 transposition protein 107 BRCT domain
26 MRPL15interactor270.618121.181Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
27 MRPL16interactor220.74552.934Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
28 MRPL17interactor190.69617.156Ribosomal_L17 (PF01196, IPR000456): Ribosomal protein L17
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
29 MRPL18interactor210.71488.922Ribosomal_L18p (PF00861, IPR005484): Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
30 MRPL19interactor240.73621.799Ribosomal_L19 (PF01245, IPR001857): Ribosomal protein L19
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
31 MRPL2interactor210.73313.718Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
32 MRPL23interactor240.52563.151Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
33 MRPL24interactor190.8485.056KOW (PF00467, IPR005824, SM00739): KOW motif
ribosomal_L24 (PF17136): Ribosomal proteins 50S L24/mitochondrial 39S L24
34 MRPL28interactor280.70127.463Ribosomal_L28 (PF00830, IPR001383): Ribosomal L28 family
35 MRPL3interactor260.69269.393Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
36 MRPL37interactor290.62361.422PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
37 MRPL38interactor280.60652.469PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095)
38 MRPL39interactor310.67130.196TGS (PF02824, IPR004095): TGS domain
DUF2469 (PF10611, IPR019592): Protein of unknown function (DUF2469)
39 MRPL4interactor310.65838.492Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
40 MRPL41interactor200.69521.049MRP-L27 (PF09809, IPR019189): Mitochondrial ribosomal protein L27
41 MRPL42interactor200.65819.294MRP-S32 (PF10210, IPR019346): Mitochondrial 28S ribosomal protein S32
42 MRPL44interactor210.67698.242dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
43 MRPL45interactor210.79510.259Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
44 MRPL47interactor320.67331.211MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
45 MRPL50interactor330.58759.173Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
46 MRPL52interactor160.74210.855SDP_N (PF12278, IPR022063): Sex determination protein N terminal
47 MRPL55interactor170.8313.980Mitoc_L55 (PF09776, IPR018615): Mitochondrial ribosomal protein L55
48 MRPL58interactor410.473278.269RF-1 (PF00472, IPR000352): RF-1 domain
49 MRPL9interactor380.532109.149Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
50 MRPS28interactor90.6944.814MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
51 MRPS30interactor340.63143.831PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
52 MRPS9interactor180.55623.988Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
53 NDUFA11interactor80.67935.4687kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
54 NDUFA8interactor90.58337.334CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
55 NDUFB10interactor80.42979.164NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
56 NDUFS1interactor110.491140.556NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
57 NDUFS3protein found in more fusions190.294494.859Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
58 NDUFS4interactor100.51169.695ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
59 NDUFS5interactor90.6679.181Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
60 NDUFS6interactor90.58345.735Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
61 NKX3-1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
62 OGDHinteractor80.39323.778E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
2-oxogl_dehyd_N (PF16078, IPR032106): 2-oxoglutarate dehydrogenase N-terminus
OxoGdeHyase_C (PF16870, IPR031717): 2-oxoglutarate dehydrogenase C-terminal
63 OXA1Lprotein found in more fusions70.8001.12760KD_IMP (PF02096, IPR001708): 60Kd inner membrane protein
64 PPM1Kprotein found in more fusions200PP2C (PF00481, IPR001932): Protein phosphatase 2C
65 RPL13interactor210.57630.954Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
66 RPL6protein found in more fusions170.59618.807Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
67 RPS8interactor270.58746.205Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
68 SCFD1interactor70.6193.245Sec1 (PF00995, IPR001619): Sec1 family
69 SLC25A3interactor120.53031.314Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
70 TIGD6interactor100CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
71 TIMMDC1interactor60.7332.836Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
72 ZC3H3interactor90.5284.358zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family

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