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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNTTIP2, ND2 (from a repository: Fri May 11 20:48:38 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins3 (11.54 %)
The number (and %) of the tumor suppressors6 (23.08 %)
Total number of binary PPIs (saturation %)51 (15.69 %)
The number (and %) of affected PPIs24 (47.06 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI3.308
Assortativity coefficient-0.3881
The network average Clustering coefficient0.456
The number (and %) of a zero Clustering coefficients7 (26.92 %)
The number (and %) of a zero Betweenness Centrality13 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DNTTIP2,MT-ND2 All fusions
Proteins found in more fusions KAT5 (see 3 fusions); RXRA (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DNTTIP2parental protein180.092406.300BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
E7 (PF00527, IPR000148): E7 protein, Early protein
Fcf2 (PF08698, IPR014810): Fcf2 pre-rRNA processing
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
2 ND2parental protein60.133215.000NA
3 DNTTinteractor100BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
4 ESR1suppressor60.50087.867Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
5 ESR2suppressor50.66768.367zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
6 GRIN1interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
CaM_bdg_C0 (PF10562, IPR018882): Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
7 HDAC11interactor100Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
8 HIST1H2BAinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
9 HIST2H3Ainteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
10 HIST3H2Ainteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
11 HIST4H4interactor30.6671.000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
12 HNRNPA1interactor40.6674.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
13 IFI16suppressor21.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
14 KAT5suppressor70.40020.200MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
15 NDUFA11interactor21.00007kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
16 NIFKinteractor40.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
17 OBSL1interactor60.4006.000BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
18 PHF8interactor100JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
19 PPARGsuppressor40.6671.000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
20 RXRAoncoprotein40.33369.767zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
21 SIRT7interactor21.0000DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
22 SPP1oncoprotein100Osteopontin (PF00865, IPR002038, SM00017): Osteopontin
23 SRConcoprotein50.167230.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
24 STK11suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
25 TIMMDC1interactor21.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
26 YME1L1interactor30.6671.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41

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