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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ISM1, MMP2 (from a repository: Sat Jul 27 21:28:31 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins5 (23.81 %)
The number (and %) of the tumor suppressors6 (28.57 %)
Total number of binary PPIs (saturation %)34 (16.19 %)
The number (and %) of affected PPIs19 (55.88 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.667
Assortativity coefficient-0.4985
The network average Clustering coefficient0.436
The number (and %) of a zero Clustering coefficients10 (47.62 %)
The number (and %) of a zero Betweenness Centrality17 (80.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MMP2,ISM1 All fusions
Proteins found in more fusions COL1A1 (see 14 fusions); HSP90AA1 (see 6 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MMP2parental protein190.053318.667Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
2 ISM1interactor000AMOP (PF03782, IPR005533, SM00723): AMOP domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3 A2Minteractor200A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 BACE1interactor100Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
5 BCANinteractor100Cytomega_UL84 (PF06284, IPR010436): Cytomegalovirus UL84 protein
EGF (PF00008, IPR000742, SM00181): EGF-like domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
6 CAND1interactor31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7 CCL7oncoprotein200IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
DUF4725 (PF15854, IPR031713): Domain of unknown function (DUF4725)
8 COL1A1oncoprotein41.0000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
9 HSP90AA1oncoprotein31.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
10 ITGAVsuppressor31.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Collectrin (PF16959, IPR031588): Renal amino acid transporter
11 ITGB1suppressor40.8330.667EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin beta chain VWA domain
PSI_integrin (PF17205): Integrin plexin domain
12 LCN2interactor200Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
13 OSBPL10interactor100Flagellar_rod (PF05149, IPR007824): Paraflagellar rod protein
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH_8 (PF15409): Pleckstrin homology domain
14 PZPinteractor21.0000A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
DUF3974 (PF13120, IPR025005): Domain of unknown function (DUF3974)
SQHop_cyclase_N (PF13249, IPR032697): Squalene-hopene cyclase N-terminal domain
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
15 TGFB1suppressor30.6671.000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
16 THBS1suppressor50.6003.667EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EndIII_4Fe-2S (PF10576, IPR003651): Iron-sulfur binding domain of endonuclease III
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
17 THBS2oncoprotein100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
18 TIMP2oncoprotein21.0000TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
19 TIMP3suppressor21.0000TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
20 TIMP4interactor100TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
21 USP12suppressor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase

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