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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)90
The number (and %) of the onco-proteins18 (20.00 %)
The number (and %) of the tumor suppressors8 (8.89 %)
Total number of binary PPIs (saturation %)240 (5.99 %)
The number (and %) of affected PPIs89 (37.08 %)
The number of possible different fusions15
PPI diameter5
PPI radius3
The average degree of PPI4.822
Assortativity coefficient-0.3816
The network average Clustering coefficient0.255
The number (and %) of a zero Clustering coefficients40 (44.44 %)
The number (and %) of a zero Betweenness Centrality27 (30.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATAD1,MME All fusions
Proteins found in more fusions IMPDH2 (see 1 fusions); HSPB1 (see 1 fusions); CSNK2A1 (see 2 fusions); MME (see 1 fusions); PEX14 (see 1 fusions); PCNA (see 1 fusions); LMNA (see 4 fusions); SLC9A3R1 (see 2 fusions); FECH (see 2 fusions); RUVBL1 (see 1 fusions); LYN (see 2 fusions); EEF1A1 (see 6 fusions); EGFR (see 2 fusions); UTRN (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATAD1parental protein130.103584.760AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
PhoH (PF02562, IPR003714): PhoH-like protein
DUF3240 (PF11582, IPR021634): Protein of unknown function (DUF3240)
AAA_18 (PF13238): AAA domain
2 MMEparental protein760.0236087.021Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
3 AGTinteractor100Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
4 ALDH3A2interactor40.33332.970Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
5 ARL1interactor30.3338.255Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
6 ARMC10suppressor2025.917Arm_2 (PF04826, IPR006911): Armadillo-like
7 ATP12Ainteractor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
8 ATP5J2interactor2021.915WRW (PF10206, IPR019344): Mitochondrial F1F0-ATP synthase, subunit f
9 BABAM1interactor2012.709VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
10 BSCL2interactor100Seipin (PF06775, IPR009617): Putative adipose-regulatory protein (Seipin)
11 CD4suppressor60.4007.458ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
12 CDK5RAP3interactor50.7002.400DUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
13 CLEC4Minteractor200Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
14 COQ9interactor7054.789COQ9 (PF08511, IPR013718): COQ9
15 CPSF6interactor30.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 CSNK2A1oncoprotein110.22293.211Pkinase (PF00069, IPR000719): Protein kinase domain
17 DNAJB12interactor30.6675.888DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1977 (PF09320, IPR015399): Domain of unknown function (DUF1977)
TPR_19 (PF14559): Tetratricopeptide repeat
18 EEF1A1suppressor130.31872.377GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
19 EGFRoncoprotein220.095495.470Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 ELAVL1oncoprotein170.050305.287RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 FAAHinteractor100Amidase (PF01425, IPR000120): Amidase
22 FAF2interactor100.13991.557DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
23 FAHD1interactor100FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
24 FAM234Ainteractor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
25 FAM83Finteractor208.206DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
26 FECHprotein found in more fusions4037.324Ferrochelatase (PF00762, IPR001015): Ferrochelatase
27 FLOT2interactor40.50033.616YjbH (PF06082, IPR010344): Exopolysaccharide biosynthesis protein YbjH
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
28 FOLH1interactor100PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
UNC-79 (PF14776): Cation-channel complex subunit UNC-79
29 GOSR1interactor21.0000V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
30 HDAC8interactor21.0000DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
31 HIST1H2AGinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
32 HSPA1Ainteractor50.60010.463HSP70 (PF00012, IPR013126): Hsp70 protein
33 HSPA4interactor110.327161.088Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
34 HSPA8oncoprotein100.44430.342HSP70 (PF00012, IPR013126): Hsp70 protein
35 HSPB1oncoprotein90.57120.109HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
36 IMPDH2protein found in more fusions3056.321IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
37 INPP5Dinteractor21.0000Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
38 IRAK2oncoprotein100Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
39 KBTBD3interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
40 KRT10interactor208.206Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
41 LAMTOR1interactor40.33312.179LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
42 LMNAprotein found in more fusions60.4006.167Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
43 LONP1interactor205.888AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
AAA_23 (PF13476): AAA domain
44 LYNoncoprotein60.20035.068Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
45 METTL7Ainteractor208.206Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
46 MRPL44interactor100dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
47 MRPS25interactor21.0000L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
48 MRVI1suppressor100MRVI1 (PF05781, IPR008677): MRVI1 protein
49 MTDHinteractor30.6670.667NST1 (PF13945, IPR025279): Salt tolerance down-regulator
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
50 MTHFD1interactor2017.029FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
51 MYH9suppressor40.5002.000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
52 NDRG1suppressor30.6671.333Ndr (PF03096, IPR004142): Ndr family
53 NDUFA10interactor40.50050.345dNK (PF01712, IPR002624): Deoxynucleoside kinase
54 NDUFA4interactor90.17967.867B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
55 NDUFA9interactor110.309200.955Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
56 NDUFB4interactor40.50050.345NDUF_B4 (PF07225, IPR009866): NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
57 NNTinteractor50.20073.808AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain
PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
58 NOLC1interactor30.6671.125DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain
Stm1_N (PF09598, IPR019084): Stm1
stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
PAF (PF15715, IPR031444): PCNA-associated factor
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NuDC (PF16273, IPR032572): Nuclear distribution C domain
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
59 NPPAinteractor100ANP (PF00212, IPR000663, SM00183): Atrial natriuretic peptide
60 NUCKS1interactor208.206FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
61 OCIAD1interactor50.6677.018OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)
62 OPA1interactor50.30051.810DUF1593 (PF07632, IPR011483): Protein of unknown function (DUF1593)
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
IncA (PF04156, IPR007285): IncA protein
Ras (PF00071, IPR001806, SM00173): Ras family
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF4061 (PF13270, IPR025271): Domain of unknown function (DUF4061)
63 PCNAoncoprotein80.333145.313PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
64 PDIA5interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
65 PEX14protein found in more fusions50.16734.327HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
66 POTEIinteractor100Actin (PF00022, IPR004000, SM00268): Actin
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
DUF3641 (PF12345, IPR024521): Protein of unknown function (DUF3641)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
67 RAP2Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
68 RBM39oncoprotein40.6671.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
69 REV3Linteractor100DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683)
70 RGPD6interactor100GRIP (PF01465, IPR000237, SM00755): GRIP domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
FlxA (PF14282, IPR025577): FlxA-like protein
TPR_19 (PF14559): Tetratricopeptide repeat
Rab_bind (PF16704, IPR032023): Rab binding domain
71 RPL30interactor40.8330.850NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
72 RPS10interactor40.6672.000S10_plectin (PF03501, IPR005326): Plectin/S10 domain
73 RPS23interactor50.6003.850Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
74 RUVBL1oncoprotein90.35739.797TIP49 (PF06068, IPR010339): TIP49 C-terminus
75 RUVBL2oncoprotein60.6005.038TIP49 (PF06068, IPR010339): TIP49 C-terminus
76 SDF4interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
77 SLC16A1oncoprotein3049.502MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
78 SLC9A3R1suppressor200EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
79 SRSF11interactor50.5003.735Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
80 SSR4interactor205.888TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
81 TM9SF1interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
82 TNPO1interactor30.3338.271Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
83 TUBB8interactor2056.321Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
84 UBAC2interactor3045.224Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
85 USP19interactor30.33317.190CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
86 UTRNprotein found in more fusions200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
87 VAPAinteractor100.200176.153DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
88 VDAC2interactor70.33379.240Porin_3 (PF01459, IPR027246): Eukaryotic porin
89 XRCC5suppressor90.46425.421Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
90 ZMPSTE24interactor208.206Peptidase_M48 (PF01435, IPR001915): Peptidase family M48
Peptidase_M48_N (PF16491, IPR032456): CAAX prenyl protease N-terminal, five membrane helices

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