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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)134
The number (and %) of the onco-proteins44 (32.84 %)
The number (and %) of the tumor suppressors20 (14.93 %)
Total number of binary PPIs (saturation %)777 (8.72 %)
The number (and %) of affected PPIs134 (17.25 %)
The number of possible different fusions31
PPI diameter4
PPI radius2
The average degree of PPI10.642
Assortativity coefficient-0.1718
The network average Clustering coefficient0.401
The number (and %) of a zero Clustering coefficients11 (8.21 %)
The number (and %) of a zero Betweenness Centrality22 (16.42 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SEPTIN9,ATXN3 All fusions
Proteins found in more fusions RFFL (see 1 fusions); TRAF6 (see 1 fusions); APP (see 5 fusions); SYVN1 (see 1 fusions); VCP (see 4 fusions); U2AF2 (see 2 fusions); TPM3 (see 4 fusions); SQSTM1 (see 5 fusions); CREB1 (see 1 fusions); MAP3K1 (see 1 fusions); PARK2 (see 1 fusions); NTRK1/TPM3 (see 2 fusions); CREBBP (see 6 fusions); HNRNPD (see 1 fusions); UBQLN1 (see 2 fusions); EWSR1 (see 1 fusions); KAT2B (see 1 fusions); COPA (see 1 fusions); BAG3 (see 4 fusions); BCL2L1 (see 1 fusions); SH3KBP1 (see 1 fusions); EP300 (see 1 fusions); UBC (see 7 fusions); PML (see 4 fusions); MSH2 (see 1 fusions); SDC2 (see 2 fusions); PSMC5 (see 2 fusions); NEDD4 (see 1 fusions); NCL (see 4 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SEPTIN9parental protein530.1173619.680Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
2 ATXN3parental protein810.0745940.258Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
3 AEBP2interactor30.33312.540Bindin (PF02084, IPR000775): Bindin
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
DUF4764 (PF15961, IPR031885): Domain of unknown function (DUF4764)
4 AMFRoncoprotein120.45561.710CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
5 ANLNoncoprotein100.44430.492Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
6 ANXA7suppressor50.30016.022Annexin (PF00191, IPR018502, SM00335): Annexin
7 APPprotein found in more fusions300.1011071.090APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ARHGAP19interactor100Endonuc-dimeris (PF09124, IPR015208): T4 recombination endonuclease VII, dimerisation
His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
9 ARHGDIAinteractor60.40013.057Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
10 ASIC1interactor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
11 BAG3oncoprotein110.26742.738BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
12 BCL2L1oncoprotein31.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
13 BCL7Csuppressor40.33313.128BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
14 C16orf70interactor21.0000UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
15 CAMSAP3interactor21.0000CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
16 CANXinteractor90.44442.858Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
17 CDC42EP4interactor80.57143.531PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
18 CDC5Linteractor210.332176.357OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
19 CDKN1Asuppressor200.232168.793CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
20 CFTRsuppressor140.256170.095ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
21 CNOT6interactor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
22 COPAprotein found in more fusions100.50046.128Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
23 CREB1oncoprotein70.6673.422bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
24 CREBBPsuppressor200.246130.465Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
25 CSNK2Binteractor120.38240.422CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
26 DDA1interactor21.0000DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
27 DNAJB2interactor50.7002.229DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
28 DND1suppressor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
29 DNM2interactor100.28967.405Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
30 EEDsuppressor130.39496.276WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 EP300oncoprotein160.40071.424Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
32 EWSR1oncoprotein220.200242.672RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
33 FERMT2interactor60.40020.039FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
34 FLNBoncoprotein90.22264.669CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
35 FN1oncoprotein250.133541.155fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
36 FOXO4suppressor30.3334.386Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
37 GSK3Bsuppressor150.198156.029Pkinase (PF00069, IPR000719): Protein kinase domain
38 HAP1interactor200HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
39 HAUS1interactor70.26763.441THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
40 HDAC3suppressor120.41831.113Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
41 HDAC6oncoprotein230.312177.046Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
42 HIF1Asuppressor120.273125.702Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
43 HLA-Aoncoprotein50.7004.766DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
44 HNRNPDoncoprotein170.358113.556CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
45 HSPA5oncoprotein290.336320.377HSP70 (PF00012, IPR013126): Hsp70 protein
46 HSPD1suppressor190.392142.106Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
47 IKBKGinteractor130.121125.095CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
48 ITCHinteractor100.36117.555C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
49 JPT1interactor100JUPITER (PF17054): Microtubule-Associated protein Jupiter
50 KAT2Bprotein found in more fusions90.53616.774Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
51 KCTD10interactor50.70017.609BTB_2 (PF02214, IPR003131): BTB/POZ domain
52 MAP3K1oncoprotein100.30649.890zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
53 MGRN1interactor40.33316.491zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
54 MKNK1interactor40.3336.362Pkinase (PF00069, IPR000719): Protein kinase domain
55 MSH2suppressor120.32790.725MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
56 NCLprotein found in more fusions130.36458.012DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
57 NCOR1oncoprotein110.43630.917BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
58 NDUFAF2interactor100NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
59 NDUFV2interactor50.40018.5952Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
60 NEDD4suppressor70.26773.937Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
61 NEDD8interactor110.35639.962ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
62 NFKBIAoncoprotein100.31130.888Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
63 NTRK1oncoprotein440.1611179.023I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
64 OBSL1interactor210.316151.974BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
65 OTUB2interactor100.42250.515Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
66 PARK2suppressor220.262280.497IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
67 PICK1oncoprotein30.6672.892Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
68 PJA1interactor80.33336.329zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
69 PMLsuppressor120.32760.702zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
70 PNKPinteractor50.40017.152PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase
AAA_33 (PF13671): AAA domain
71 PSMC5protein found in more fusions170.45874.064AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
72 PSRC1interactor40.16721.166GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
73 RAD23Aoncoprotein150.38542.931UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
74 RAD23Bsuppressor110.52717.703K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
75 RFFLprotein found in more fusions31.0000FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Armet (PF10208, IPR019345): Degradation arginine-rich protein for mis-folding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
76 RIDAinteractor31.0000Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
77 RPS6KA1oncoprotein80.50028.204Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
78 RSF1oncoprotein21.0000DDT (PF02791, IPR004022, SM00571): DDT domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PHD (PF00628, IPR019787, SM00249): PHD-finger
UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239)
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
79 SCO2interactor60.33367.892SCO1-SenC (PF02630, IPR003782): SCO1/SenC
80 SCP2interactor40.6671.601SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
81 SDC2protein found in more fusions304.313Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
82 SEC22Binteractor90.306121.553Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
83 SEPTIN1interactor100.44489.568Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20
Septin (PF00735, IPR000038): Septin
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
84 SEPTIN11interactor120.43939.121Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
85 SEPTIN2oncoprotein180.405135.203FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
86 SEPTIN3interactor80.9520.429Septin (PF00735, IPR000038): Septin
87 SEPTIN6oncoprotein140.42973.241Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
88 SEPTIN7interactor160.46784.210Fez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
89 SH3KBP1protein found in more fusions120.327125.611Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
90 SLC3A2interactor70.42928.909Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459)
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
91 SNW1protein found in more fusions240.308299.583SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
92 SPRTNinteractor40.6674.741GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
93 SQSTM1oncoprotein220.262194.468PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
94 SRIoncoprotein40.3336.507EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
95 SRRM2interactor190.421154.137cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
96 STK11suppressor50.40026.161Pkinase (PF00069, IPR000719): Protein kinase domain
97 STUB1suppressor180.397105.829U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
98 SUCLG1interactor30.6670.667CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
99 SUCLG2interactor40.5002.373ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
100 SUMO1interactor90.42921.810Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
101 SVILinteractor40.5004.012Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
102 SYVN1protein found in more fusions70.5336.227Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
103 TEX11interactor40.16726.726SPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
104 TIMM23interactor21.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
105 TIMM44interactor50.50026.168Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
106 TK1oncoprotein80.28664.373TK (PF00265, IPR001267, SM00203): Thymidine kinase
107 TMCO1interactor100DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
108 TMED9interactor30.6670.500EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
109 TOMM20Linteractor100MAS20 (PF02064, IPR002056): MAS20 protein import receptor
QCR10 (PF09796, IPR019182): Ubiquinol-cytochrome-c reductase complex subunit (QCR10)
110 TOR1AIP1interactor21.0000LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Pap_E4 (PF02711, IPR003861): E4 protein
111 TPM3oncoprotein70.26727.615Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
112 TRAF6protein found in more fusions150.37464.203SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
113 TRIM54interactor80.38124.264DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
114 TRIM55interactor100.278128.320Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
115 TRIM63interactor100.41724.317DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
116 TUBA1Aoncoprotein140.29793.769Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
117 TUBBinteractor160.34295.154Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
118 U2AF2protein found in more fusions210.432123.232RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
119 UBCprotein found in more fusions390.186853.106ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
120 UBE2L3interactor130.31859.871UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
121 UBE2Sinteractor80.33319.871ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
122 UBE4Bsuppressor90.42969.749DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
123 UBQLN1protein found in more fusions130.40947.992Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
124 UBXN6interactor70.19052.216PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
125 UQCRFS1interactor21.0000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
126 UQCRFS1P1interactor100NA
127 USP13interactor100.42224.791UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
128 USP21interactor90.46418.634UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
129 VAMP2interactor31.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
130 VAPBinteractor70.429119.614ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
131 VCPprotein found in more fusions420.1561185.411AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
132 VMA21interactor100VMA21 (PF09446, IPR019013): VMA21-like domain
133 XPO1interactor240.141550.671CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
134 XRCC6oncoprotein190.320144.126Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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