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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MGAT2, DENND1A (from a repository: Wed Dec 11 18:42:45 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins3 (23.08 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)30 (38.46 %)
The number (and %) of affected PPIs11 (36.67 %)
The number of possible different fusions1
PPI diameter4
PPI radius2
The average degree of PPI4.615
Assortativity coefficient-0.0515
The network average Clustering coefficient0.560
The number (and %) of a zero Clustering coefficients4 (30.77 %)
The number (and %) of a zero Betweenness Centrality7 (53.85 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DENND1A,MGAT2 All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DENND1Aparental protein100.40061.000dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
2 MGAT2parental protein100MGAT2 (PF05060, IPR007754): N-acetylglucosaminyltransferase II (MGAT2)
3 ANAPC15interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
4 ATL2interactor100GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
5 CLTBinteractor61.0000Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
6 CLTConcoprotein61.0000Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
7 GAKoncoprotein61.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
8 GTSE1interactor70.8108.000GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
9 LIMA1suppressor70.7625.000LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
10 PEX19interactor2022.000Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
11 PICALMoncoprotein70.8108.000ANTH (PF07651, IPR011417): ANTH domain
12 XPO1interactor40.50040.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
13 YWHABinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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