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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MFAP4, SOCS5 (from a repository: Fri Feb 16 13:02:23 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins7 (50.00 %)
The number (and %) of the tumor suppressors1 (7.14 %)
Total number of binary PPIs (saturation %)35 (38.46 %)
The number (and %) of affected PPIs12 (34.29 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI3.857
Assortativity coefficient-0.2446
The network average Clustering coefficient0.305
The number (and %) of a zero Clustering coefficients3 (21.43 %)
The number (and %) of a zero Betweenness Centrality3 (21.43 %)


List of the fusions

PPI for parental proteins: MFAP4,SOCS5 All fusions
Proteins found in more fusions TP53 (see 3 fusions); APP (see 4 fusions); UBC (see 1 fusions); GRB2 (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MFAP4parental protein40.1677.400Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
2 SOCS5parental protein80.14367.400SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
3 ALKoncoprotein202.500MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
4 APPprotein found in more fusions60.30021.600APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 AURKAoncoprotein40.3334.100Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
6 CASP3interactor31.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
7 DCUN1D1interactor30.6672.500Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
8 EGFRoncoprotein70.40017.233Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 GRB2oncoprotein60.20015.267SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
10 IL4Roncoprotein100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal
11 RNF115interactor50.3335.800Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zinc_ribbon_9 (PF14369): zinc-ribbon
12 TMBIM1interactor100Bax1-I (PF01027, IPR006214): Inhibitor of apoptosis-promoting Bax1
13 TP53suppressor50.3336.200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
14 UBCprotein found in more fusions70.40018.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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