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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAPK7, MFAP4 (from a repository: Sat Aug 17 02:58:47 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)66
The number (and %) of the onco-proteins31 (46.97 %)
The number (and %) of the tumor suppressors8 (12.12 %)
Total number of binary PPIs (saturation %)313 (14.59 %)
The number (and %) of affected PPIs66 (21.09 %)
The number of possible different fusions21
PPI diameter3
PPI radius2
The average degree of PPI8.606
Assortativity coefficient-0.2803
The network average Clustering coefficient0.630
The number (and %) of a zero Clustering coefficients4 (6.06 %)
The number (and %) of a zero Betweenness Centrality22 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAPK7,MFAP4 All fusions
Proteins found in more fusions APP (see 5 fusions); ACTB (see 7 fusions); AURKA (see 1 fusions); YWHAG (see 1 fusions); BAG3 (see 4 fusions); MAP3K2 (see 2 fusions); HSP90AA1 (see 6 fusions); UBE2C (see 1 fusions); YWHAZ (see 5 fusions); FOS (see 4 fusions); HSP90AB1 (see 3 fusions); GRB2 (see 1 fusions); CDC37 (see 2 fusions); ATP5A1 (see 1 fusions); SGK1 (see 5 fusions); PML (see 4 fusions); HSP90AA1/TUBB (see 1 fusions); YWHAH (see 2 fusions); TP53 (see 3 fusions); GAPDH (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAPK7parental protein620.1052709.424Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
2 MFAP4parental protein40.1677.451Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
3 ACTBoncoprotein50.6672.636Actin (PF00022, IPR004000, SM00268): Actin
4 ACTN4interactor30.6670.750CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
5 APPprotein found in more fusions170.32590.705APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ATP5A1protein found in more fusions120.6913.876ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
7 AURKAoncoprotein110.46722.390Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
8 BAG3oncoprotein120.56417.709BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
9 C5orf30interactor21.0000UNC119_bdg (PF15435, IPR029219): UNC119-binding protein C5orf30 homologue
10 CDC37protein found in more fusions130.60614.464CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
11 DOT1Loncoprotein21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DivIC (PF04977, IPR007060): Septum formation initiator
DOT1 (PF08123, IPR013110): Histone methylation protein DOT1
ZapB (PF06005, IPR009252): Cell division protein ZapB
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
12 DSC1interactor41.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
UPF0114 (PF03350, IPR005134): Uncharacterized protein family, UPF0114
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
13 DSG1interactor41.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
14 EGLN3suppressor31.00002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
15 ETS1oncoprotein40.6670.613Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
16 FGF21interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
17 FOSoncoprotein40.6670.722bZIP_1 (PF00170, IPR004827): bZIP transcription factor
18 FSCN1oncoprotein31.0000Fascin (PF06268, IPR022768): Fascin domain
19 GANABsuppressor40.8330.667Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
20 GAPDHoncoprotein120.6917.123Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
21 GJA1suppressor31.0000Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43)
Connexin (PF00029, IPR013092, SM00037): Connexin
SieB (PF14163, IPR025982): Super-infection exclusion protein B
22 GOLGB1interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
Tup_N (PF08581, IPR013890): Tup N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
SOGA (PF11365, IPR027881): Protein SOGA
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
CT_C_D (PF02682): Carboxyltransferase domain, subdomain C and D
23 GPSM3interactor21.0000GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
24 GRB2oncoprotein160.41956.365SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
25 HSP90AA1oncoprotein250.315139.932HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
26 HSP90AB1oncoprotein180.56626.638HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
27 HSP90B1suppressor50.7002.722CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
28 HSPA4interactor120.50017.113Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
29 HSPA5oncoprotein150.50529.334HSP70 (PF00012, IPR013126): Hsp70 protein
30 JUPsuppressor60.6673.333Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
31 LDHCinteractor100Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
32 MAP2K5oncoprotein60.8000.467PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
33 MAP3K2protein found in more fusions90.5369.763PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
34 MEF2Aoncoprotein50.5004.594TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
35 MEF2Concoprotein30.6670.750SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
36 MEF2Doncoprotein40.6671.897DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
37 MYLK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
38 NFE2L2oncoprotein21.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
39 NR1I2suppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
40 NTRK1oncoprotein280.288217.286I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
41 PFDN1interactor61.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
42 PFDN2interactor61.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
43 PFDN4interactor61.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
44 PFDN5interactor80.60734.447Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
45 PFDN6interactor61.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
46 PKMoncoprotein120.50023.427PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
47 PMLsuppressor70.40011.026zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
48 PPP3CAinteractor50.40011.002Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
49 PRKCAinteractor90.42914.707C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
50 PRKCZinteractor90.7143.169PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
51 PTPRRinteractor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3149 (PF11346, IPR021494): Protein of unknown function (DUF3149)
52 RAF1oncoprotein150.50517.568Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
53 RNF115interactor50.16712.332Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zinc_ribbon_9 (PF14369): zinc-ribbon
54 SGK1oncoprotein70.7330.891Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
55 SH2D2Ainteractor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
56 TP53suppressor200.269152.900DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
57 TUBBprotein found in more fusions160.59222.436Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
58 UBE2Concoprotein31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
59 VBP1interactor70.8103.167Prefoldin (PF02996, IPR004127): Prefoldin subunit
60 XPO1interactor140.44049.281CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
61 YWHABinteractor170.50766.91614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
62 YWHAEoncoprotein170.56621.99814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
63 YWHAGprotein found in more fusions170.52524.58914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
64 YWHAHprotein found in more fusions120.7646.27314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
65 YWHAZprotein found in more fusions210.39571.14914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
66 ZBED6CLinteractor100NA

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