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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAP3K3, PTPN21 (from a repository: Fri Oct 4 03:08:56 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins21 (40.38 %)
The number (and %) of the tumor suppressors9 (17.31 %)
Total number of binary PPIs (saturation %)215 (16.21 %)
The number (and %) of affected PPIs51 (23.72 %)
The number of possible different fusions16
PPI diameter5
PPI radius3
The average degree of PPI7.154
Assortativity coefficient-0.2542
The network average Clustering coefficient0.471
The number (and %) of a zero Clustering coefficients5 (9.62 %)
The number (and %) of a zero Betweenness Centrality9 (17.31 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP3K3,PTPN21 All fusions
Proteins found in more fusions NEDD4L (see 4 fusions); COPS5 (see 1 fusions); TRAF6 (see 1 fusions); MAP3K7 (see 7 fusions); SQSTM1 (see 5 fusions); MARK2 (see 2 fusions); CDC37 (see 2 fusions); YWHAG (see 1 fusions); MTOR (see 1 fusions); MAP3K2 (see 2 fusions); ZBTB16 (see 4 fusions); RIPK1 (see 1 fusions); HSP90AA1 (see 6 fusions); EGFR (see 2 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAP3K3parental protein470.1191471.997PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
2 PTPN21parental protein40.167107.901FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 BIRC2oncoprotein70.6002.748BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
4 BMXinteractor40.66738.654BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_8 (PF15409): Pleckstrin homology domain
5 BRCA1suppressor80.33311.301BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 CDC37protein found in more fusions110.51124.628CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
7 CHUKsuppressor130.50033.323Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
8 COPS5protein found in more fusions90.42917.173JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9 EGFRoncoprotein170.250130.711Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
10 FLNAsuppressor60.40021.881CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
11 FUSsuppressor40.6671.042Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
12 GAB1oncoprotein30.6671.067PH (PF00169, IPR001849, SM00233): PH domain
13 GLRX3interactor200Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Thioredoxin (PF00085, IPR013766): Thioredoxin
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
14 GTF2Iinteractor30.6670.500GTF2I (PF02946, IPR004212): GTF2I-like repeat
15 HSP90AA1oncoprotein210.268181.459HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
16 HSP90AA2Poncoprotein21.0000DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
17 HSPA4interactor90.5008.802Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
18 IP6K3interactor100IPK (PF03770, IPR005522): Inositol polyphosphate kinase
19 IRAK1interactor110.6008.621Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
20 KIF1Cinteractor30.33326.269FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
21 KIFC3oncoprotein40.6670.633Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
22 MAP2K3interactor50.5002.867Pkinase (PF00069, IPR000719): Protein kinase domain
23 MAP2K4suppressor80.38112.382Pkinase (PF00069, IPR000719): Protein kinase domain
24 MAP2K5oncoprotein50.6671.375PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
25 MAP2K7interactor60.7331.519Pkinase (PF00069, IPR000719): Protein kinase domain
26 MAP3K2protein found in more fusions150.20970.523PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
27 MAP3K7oncoprotein140.44928.193Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
28 MARK2protein found in more fusions70.4677.716DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
29 MBPinteractor21.0000Myelin_MBP (PF01669, IPR000548): Myelin basic protein
30 MTORoncoprotein100.5287.723DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
31 NBR1oncoprotein40.6671.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
32 NEDD4suppressor70.33323.138Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
33 NEDD4Lsuppressor70.5335.186WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
34 PARD6Binteractor100PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
35 PDRG1interactor30.6671.067Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
36 PFDN2interactor30.6670.667Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
37 PPP2CAsuppressor50.5002.833Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38 PRKACAinteractor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
39 RIPK1protein found in more fusions100.5567.935Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
40 SMURF1interactor70.3335.738C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
41 SPAG9interactor30.6670.500DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IncA (PF04156, IPR007285): IncA protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
42 SQSTM1oncoprotein130.31835.548PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
43 SRConcoprotein110.267150.048Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
44 TOM1L1interactor30.6675.414GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
45 TRAF6protein found in more fusions130.34854.593SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
46 TRAF7oncoprotein21.0000Sina (PF03145, IPR018121): Seven in absentia protein family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
WD40_like (PF17005, IPR031544): WD40-like domain
47 VWFinteractor100Antistasin (PF02822, IPR004094): Antistasin family
C8 (PF08742, IPR014853, SM00832): C8 domain
Metallothio_5 (PF02067, IPR000966): Metallothionein family 5
Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
VWA_N2 (PF16164, IPR032361): VWA N-terminal
48 XIAPinteractor90.4648.067BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
49 XPO1interactor150.35255.554CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
50 YWHAEoncoprotein80.42956.66314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
51 YWHAGprotein found in more fusions90.46459.04314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
52 ZBTB16suppressor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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