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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PDPN, MEIS2 (from a repository: Fri Aug 16 16:39:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins8 (29.63 %)
The number (and %) of the tumor suppressors2 (7.41 %)
Total number of binary PPIs (saturation %)56 (15.95 %)
The number (and %) of affected PPIs26 (46.43 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI3.556
Assortativity coefficient-0.4370
The network average Clustering coefficient0.374
The number (and %) of a zero Clustering coefficients12 (44.44 %)
The number (and %) of a zero Betweenness Centrality16 (59.26 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PDPN,MEIS2 All fusions
Proteins found in more fusions APP (see 5 fusions); MEIS2 (see 1 fusions); SP1 (see 1 fusions); SQSTM1 (see 5 fusions); TRIM25 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PDPNparental protein100Podoplanin (PF05808, IPR008783): Podoplanin
Sensor (PF13796, IPR025828): Putative sensor
2 MEIS2parental protein250.083475.900Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
3 ANXA1suppressor31.0000Annexin (PF00191, IPR018502, SM00335): Annexin
4 APPprotein found in more fusions60.5004.333APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARNT2interactor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
6 C1orf94interactor31.0000DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
7 CRBNinteractor100LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
8 DGCR6interactor40.6672.000DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
9 GNB4interactor100Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
10 LINC00238interactor100MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
11 LMX1Binteractor70.5246.167LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
12 MAB21L1interactor60.6672.500Mab-21 (PF03281, IPR024810): Mab-21 protein
13 MAB21L2interactor60.4005.167Mab-21 (PF03281, IPR024810): Mab-21 protein
14 MEIS1oncoprotein50.8000.733Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
15 MEIS3interactor100Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
16 OSGIN1suppressor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
17 PBX1oncoprotein50.8000.733PBC (PF03792, IPR005542): PBC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
18 PBX2oncoprotein50.5003.733PBC (PF03792, IPR005542): PBC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19 PBX3interactor50.5003.733Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
PBC (PF03792, IPR005542): PBC domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
20 PBX4interactor100PBC (PF03792, IPR005542): PBC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
21 PIGLinteractor100PIG-L (PF02585, IPR003737): GlcNAc-PI de-N-acetylase
22 SOX2oncoprotein40.6671.000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
23 SP1protein found in more fusions200zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
24 SQSTM1oncoprotein200PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
25 TOM1L1interactor100GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
26 TRIM25protein found in more fusions200Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
27 ZNHIT3interactor21.0000FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain
zf-HIT (PF04438, IPR007529): HIT zinc finger

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