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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ME1, CACNA2D1 (from a repository: Sat Jan 7 00:13:15 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins9 (20.45 %)
The number (and %) of the tumor suppressors2 (4.55 %)
Total number of binary PPIs (saturation %)95 (10.04 %)
The number (and %) of affected PPIs42 (44.21 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.864
Assortativity coefficient-0.5371
The network average Clustering coefficient0.309
The number (and %) of a zero Clustering coefficients20 (45.45 %)
The number (and %) of a zero Betweenness Centrality24 (54.55 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CACNA2D1,ME1 All fusions
Proteins found in more fusions CUL3 (see 1 fusions); BOP1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CACNA2D1parental protein220.0131134.522dCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
2 ME1parental protein200.163550.577malic (PF00390, IPR012301): Malic enzyme, N-terminal domain
Malic_M (PF03949, IPR012302, SM00919): Malic enzyme, NAD binding domain
3 ABCE1interactor60.300333.129ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 BOP1oncoprotein70.80015.865BOP1NT (PF08145, IPR012953, SM01035): BOP1NT (NUC169) domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3038 (PF11237, IPR021399): Protein of unknown function (DUF3038)
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 BTNL8interactor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
6 CCDC8interactor60.200172.259Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
7 CNOT2interactor100NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family
8 CTTNoncoprotein60.50031.008FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 CUL3protein found in more fusions120.236398.671Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 DNAAF2interactor100Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
11 EFNB2interactor100Ephrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
12 ERLIN2interactor100Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
13 GARSinteractor70.6196.000HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
14 GLT8D2interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
15 GORASP2interactor80.71421.318GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
16 GPX4interactor21.0000GSHPx (PF00255, IPR000889): Glutathione peroxidase
17 GSTK1interactor200DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
18 GTF2A1oncoprotein80.60715.353TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
19 HNRNPUinteractor30.33380.536CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
20 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 ITM2Binteractor100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SpoVG (PF04026, IPR007170): SpoVG
22 LMAN2interactor21.0000Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Tad (PF13400, IPR028087): Putative Flp pilus-assembly TadE/G-like
23 MSNoncoprotein40.33331.246DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
24 MYH7Binteractor100Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
25 NDUFS4interactor100ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
26 NFYAinteractor21.0000CBFB_NFYA (PF02045, IPR001289): CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
MSP1_C (PF07462, IPR010901): Merozoite surface protein 1 (MSP1) C-terminus
FixG_C (PF11614, IPR032879): IG-like fold at C-terminal of FixG, putative oxidoreductase
DUF4237 (PF14021, IPR025331): Protein of unknown function (DUF4237)
27 NMIinteractor31.0000IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
28 PKMoncoprotein40.33387.023PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
29 PON2interactor2075.858Arylesterase (PF01731, IPR002640): Arylesterase
30 PREPinteractor100Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
31 PTCH1suppressor100Patched (PF02460, IPR003392): Patched family
32 PTPRKsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
33 RAB11Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
34 RPUSD2interactor60.8009.990PseudoU_synth_2 (PF00849, IPR006145): RNA pseudouridylate synthase
35 STIP1interactor40.33392.102TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
36 STT3Binteractor100STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
37 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
38 TAZinteractor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
39 TBCDinteractor80.429183.555HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
40 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
41 TOM1oncoprotein30.6672.139GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
42 UGDHinteractor80.7143.2333HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
UDPG_MGDP_dh (PF00984, IPR014026): UDP-glucose/GDP-mannose dehydrogenase family, central domain
UDPG_MGDP_dh_C (PF03720, IPR014027, SM00984): UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
UDPG_MGDP_dh_N (PF03721, IPR001732): UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
43 USP7oncoprotein50.500117.615MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
44 VTA1interactor21.0000Vta1 (PF04652): Vta1 like

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