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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAZ, DMPK (from a repository: Tue Jul 30 06:59:46 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins11 (39.29 %)
The number (and %) of the tumor suppressors3 (10.71 %)
Total number of binary PPIs (saturation %)75 (19.84 %)
The number (and %) of affected PPIs26 (34.67 %)
The number of possible different fusions9
PPI diameter4
PPI radius3
The average degree of PPI4.071
Assortativity coefficient-0.3700
The network average Clustering coefficient0.323
The number (and %) of a zero Clustering coefficients10 (35.71 %)
The number (and %) of a zero Betweenness Centrality10 (35.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DMPK,MAZ All fusions
Proteins found in more fusions FOS (see 4 fusions); CSNK2A1 (see 2 fusions); HSP90AA1 (see 6 fusions); ATN1 (see 1 fusions); MAPK14 (see 1 fusions); EWSR1 (see 1 fusions); ATXN1 (see 3 fusions); RAC1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DMPKparental protein140.033328.702AP_endonuc_2 (PF01261, IPR013022): Xylose isomerase-like TIM barrel
DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like
Pkinase (PF00069, IPR000719): Protein kinase domain
2 MAZparental protein120.167151.471zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2057 (PF09829, IPR018635): Uncharacterized protein conserved in bacteria (DUF2057)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
3 ANXA7suppressor4025.474Annexin (PF00191, IPR018502, SM00335): Annexin
4 ATN1protein found in more fusions305.322Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
5 ATXN1protein found in more fusions31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 BPTFinteractor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DDT (PF02791, IPR004022, SM00571): DDT domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GRP (PF07172, IPR010800): Glycine rich protein family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SDA1 (PF05285, IPR007949): SDA1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
7 CSNK2A1oncoprotein100.33360.679Pkinase (PF00069, IPR000719): Protein kinase domain
8 DCCsuppressor204.660fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
9 EWSR1oncoprotein70.13359.108RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 FOSoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
11 GEMIN4interactor31.0000NA
12 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
13 HOXA2interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
14 HSP90AA1oncoprotein60.20078.391HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
15 HSPB2interactor200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
16 JUNoncoprotein80.38137.031bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
17 KEAP1oncoprotein40.33315.738BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
18 LGR4interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
19 MAPK14oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
20 MOV10interactor4029.322AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
21 NXF1interactor60.20029.798NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
22 OTUB1interactor50.30016.334Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
23 PIN1suppressor50.30054.717Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
24 RAC1oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
25 RPS10interactor4037.800S10_plectin (PF03501, IPR005326): Plectin/S10 domain
26 SMN1interactor40.33313.655SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
27 TK1oncoprotein306.991TK (PF00265, IPR001267, SM00203): Thymidine kinase
28 UBQLN4interactor50.33318.807CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain

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