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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CYP19A1, MAT2A (from a repository: Sun Sep 23 06:20:48 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)37
The number (and %) of the onco-proteins11 (29.73 %)
The number (and %) of the tumor suppressors3 (8.11 %)
Total number of binary PPIs (saturation %)148 (22.22 %)
The number (and %) of affected PPIs36 (24.32 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI7.351
Assortativity coefficient-0.2843
The network average Clustering coefficient0.564
The number (and %) of a zero Clustering coefficients5 (13.51 %)
The number (and %) of a zero Betweenness Centrality11 (29.73 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAT2A,CYP19A1 All fusions
Proteins found in more fusions COPS5 (see 1 fusions); GRK5 (see 4 fusions); CUL3 (see 1 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAT2Aparental protein360.170692.928S-AdoMet_synt_C (PF02773, IPR022630): S-adenosylmethionine synthetase, C-terminal domain
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
S-AdoMet_synt_N (PF00438, IPR022628): S-adenosylmethionine synthetase, N-terminal domain
2 CYP19A1oncoprotein000p450 (PF00067, IPR001128): Cytochrome P450
3 ABCB7interactor21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
4 ACSS2interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
ACAS_N (PF16177, IPR032387): Acetyl-coenzyme A synthetase N-terminus
5 ASNSoncoprotein50.5004.667Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
6 BCL2oncoprotein31.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
7 CAPNS1interactor30.6671.000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 COPS5protein found in more fusions130.51518.313JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9 CSTBoncoprotein40.6671.200Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
10 CUL3protein found in more fusions140.47422.549Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
11 DFFAsuppressor50.9000.250CIDE-N (PF02017, IPR003508): CIDE-N domain
DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain
T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C
SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
12 EEF2interactor120.56116.737EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
13 ELAVL1oncoprotein90.6794.321RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 FBXO6interactor60.5332.336FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
15 FUSsuppressor100.6447.769Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
16 GRK5protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
17 HGSinteractor50.7001.122FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
18 HIST1H3Einteractor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
19 MAT1Ainteractor41.0000S-AdoMet_synt_C (PF02773, IPR022630): S-adenosylmethionine synthetase, C-terminal domain
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
S-AdoMet_synt_N (PF00438, IPR022628): S-adenosylmethionine synthetase, N-terminal domain
20 MAT2Binteractor100.44418.533RmlD_sub_bind (PF04321, IPR005913): RmlD substrate binding domain
21 MCM2oncoprotein150.45131.866AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
22 MTHFD1interactor60.6671.667FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
23 NMD3interactor30.6670.667DUF1816 (PF08846, IPR014945): Domain of unknown function (DUF1816)
NMD3 (PF04981, IPR007064): NMD3 family
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
24 NTRK1oncoprotein190.39261.306I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
25 RPLP0P6interactor60.7331.091NA
26 RPS3interactor100.5567.962KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
27 RPS3Ainteractor120.54514.417Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
28 SDHBsuppressor31.0000Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
29 SLC33A1interactor100Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
30 SMURF1interactor80.6671.897C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
31 TMEM213interactor100TMEM213 (PF15192, IPR028121): TMEM213 family
32 TUBA1Aoncoprotein110.49113.188Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
33 TUBBinteractor150.48626.495Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
34 UBE2Iinteractor70.4675.519UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 UGDHinteractor50.8330.2503HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
UDPG_MGDP_dh (PF00984, IPR014026): UDP-glucose/GDP-mannose dehydrogenase family, central domain
UDPG_MGDP_dh_C (PF03720, IPR014027, SM00984): UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
UDPG_MGDP_dh_N (PF03721, IPR001732): UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
36 VCPKMTinteractor100Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
37 XPO1interactor130.44929.949CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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