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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)118
The number (and %) of the onco-proteins19 (16.10 %)
The number (and %) of the tumor suppressors6 (5.08 %)
Total number of binary PPIs (saturation %)294 (4.26 %)
The number (and %) of affected PPIs118 (40.14 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI4.373
Assortativity coefficient-0.4619
The network average Clustering coefficient0.313
The number (and %) of a zero Clustering coefficients52 (44.07 %)
The number (and %) of a zero Betweenness Centrality51 (43.22 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CCDC57,LTBR All fusions
Proteins found in more fusions ZMYND11 (see 1 fusions); AES (see 3 fusions); TRAF4 (see 1 fusions); TRIM4 (see 1 fusions); CEP57L1 (see 1 fusions); SKI (see 1 fusions); HDAC5 (see 1 fusions); FGFR1 (see 2 fusions); OFD1 (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CCDC57parental protein480.0144536.802CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Fez1 (PF06818): Fez1
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
SlyX (PF04102, IPR007236): SlyX
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF3983 (PF13137, IPR025041): Protein of unknown function (DUF3983)
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
2 LTBRparental protein700.0298033.944Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
3 AESprotein found in more fusions120.145594.473TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
4 AQP1interactor40.33358.608MIP (PF00230, IPR000425): Major intrinsic protein
5 ARHGEF18interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
6 ARL4Ainteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
7 BIRC2oncoprotein100.58379.034BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 BLZF1interactor20100.868DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
ZapB (PF06005, IPR009252): Cell division protein ZapB
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
9 BORCS6interactor30104.400DUF2365 (PF10157, IPR019314): Uncharacterized conserved protein (DUF2365)
10 CBX8interactor40.33344.220Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
11 CCDC112interactor100DivIC (PF04977, IPR007060): Septum formation initiator
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
PGA_cap (PF09587, IPR019079, SM00854): Bacterial capsule synthesis protein PGA_cap
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF3596 (PF12167, IPR022000): Domain of unknown function (DUF3596)
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
12 CCDC113interactor100DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
DUF2808 (PF10989, IPR021256): Protein of unknown function (DUF2808)
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
13 CCDC120interactor30.333105.130HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
DUF3338 (PF11819, IPR021774): Domain of unknown function (DUF3338)
14 CCDC121interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
DUF4515 (PF14988, IPR032777): Domain of unknown function (DUF4515)
15 CCDC77interactor40.83323.037Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
BCL9 (PF11502, IPR024670): B-cell lymphoma 9 protein
CotJB (PF12652, IPR024207): CotJB protein
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
16 CCDC93interactor100Cir_Bir_Yir (PF06022, IPR006477): Plasmodium variant antigen protein Cir/Yir/Bir
Iron_permease (PF04120, IPR007251): Low affinity iron permease
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
17 CCHCR1interactor70.467146.113HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
18 CDC20Binteractor40.167108.580WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
19 CEP120interactor80.464106.506C2 (PF00168, IPR000008, SM00239): C2 domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DUF3668 (PF12416, IPR022136): Cep120 protein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
20 CEP131interactor60.533121.172DASH_Spc19 (PF08287, IPR013251): Spc19
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
DUF743 (PF05332, IPR007996): Protein of unknown function (DUF743)
DUF826 (PF05696, IPR008544): Protein of unknown function (DUF826)
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Histone_HNS (PF00816, IPR001801): H-NS histone family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
UCR_hinge (PF02320, IPR023184): Ubiquinol-cytochrome C reductase hinge protein
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
DUF2284 (PF10050, IPR019271): Predicted metal-binding protein (DUF2284)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
Phage_holin_2_4 (PF16082, IPR032124): Bacteriophage holin family, superfamily II-like
21 CEP57L1protein found in more fusions90.179222.438Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
XhlA (PF10779, IPR019715): Haemolysin XhlA
YqzE (PF14038, IPR025622): YqzE-like protein
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
22 CEP95interactor21.0000HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
IncA (PF04156, IPR007285): IncA protein
DUF4094 (PF13334, IPR025298): Domain of unknown function (DUF4094)
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
23 CISD2interactor100zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
24 CSNK1Einteractor60.300182.325APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
25 CTU1interactor100ATP_bind_3 (PF01171, IPR011063): PP-loop family
zn-ribbon_14 (PF16503, IPR032442): Zinc-ribbon
26 CWF19L2interactor2027.736CwfJ_C_1 (PF04677, IPR006768): Protein similar to CwfJ C-terminus 1
CwfJ_C_2 (PF04676, IPR006767): Protein similar to CwfJ C-terminus 2
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Pap_E4 (PF02711, IPR003861): E4 protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
MRI (PF15325, IPR028278): Modulator of retrovirus infection
27 DEUP1suppressor60.300164.382APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
28 DIABLOsuppressor60.9001.597Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
29 EGFL7interactor100Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
EMI (PF07546, IPR011489): EMI domain
SlyX (PF04102, IPR007236): SlyX
30 FAM161Ainteractor50.33358.452YajC (PF02699, IPR003849): Preprotein translocase subunit
UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564
31 FAM50Binteractor2027.736Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
32 FAM90A1interactor30.33368.030zf-CCHC_6 (PF15288): Zinc knuckle
33 FGFR1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
34 GPKOWinteractor2031.747KOW (PF00467, IPR005824, SM00739): KOW motif
G-patch_2 (PF12656, IPR026822): G-patch domain
35 HAUS1interactor70.200179.631THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
36 HBA2interactor20102.837Globin (PF00042, IPR000971): Globin
37 HDAC5protein found in more fusions40228.955Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
38 HES1oncoprotein21.0000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
39 HGSinteractor30168.672FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
40 HSFX1interactor100HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
41 IFT81interactor30.66723.037Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Nif11 (PF07862, IPR012903): Nitrogen fixation protein of unknown function
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
NPBW (PF15180, IPR013297): Neuropeptides B and W
42 IKBKGinteractor120.49174.314CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
43 IQCB1interactor30.333147.406DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
44 KIAA0368interactor2073.364HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
45 LENG1interactor21.0000Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
DUF3323 (PF11796, IPR024466): Protein of unknown function N-terminus (DUF3323)
46 LINC00526interactor21.0000NA
47 MAP4K4interactor100CNH (PF00780, IPR001180, SM00036): CNH domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM165 (PF14981, IPR028023): FAM165 family
SOBP (PF15279, IPR026092): Sine oculis-binding protein
FAM60A (PF15396, IPR026065): Protein Family FAM60A
48 MAP7D1interactor100BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
49 MFAP1interactor30.6670.650MFAP1 (PF06991, IPR009730): Microfibril-associated/Pre-mRNA processing
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
50 MGAinteractor100AT_hook (PF02178, IPR017956, SM00384): AT hook motif
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
T-box (PF00907, IPR001699, SM00425): T-box
DUF4801 (PF16059, IPR032060): Domain of unknown function (DUF4801)
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers
51 MKI67interactor20117.933FHA (PF00498, IPR000253, SM00240): FHA domain
K167R (PF08065, IPR012568): K167R (NUC007) repeat
PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding
AROS (PF15684, IPR023262): Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
52 NAPRTinteractor100NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
53 NBR1oncoprotein31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
54 NELFEinteractor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
FLO_LFY (PF01698, IPR002910): Floricaula / Leafy protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
55 NUMA1oncoprotein30.33347.968Colicin (PF01024, IPR000293): Colicin pore forming domain
Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
56 ODF2interactor110.327213.201ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase
Invasin_D3 (PF09134, IPR015217): Invasin, domain 3
Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
57 OFD1protein found in more fusions130.197684.766APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
58 PER1oncoprotein2061.162PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SPX (PF03105, IPR004331): SPX domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
59 PLK1suppressor50.30078.441Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
60 POLRMTinteractor100DUF615 (PF04751, IPR006839): Protein of unknown function (DUF615)
PSD2 (PF07624, IPR011478): Protein of unknown function (DUF1585)
RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
61 POM121interactor100Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
62 PPHLN1interactor100Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
63 PPP1R18interactor2031.747Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
64 PRAM1interactor100hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
65 PRC1interactor21.0000VIT1 (PF01988, IPR008217): VIT family
MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family)
66 PRPF31interactor40.6671.733Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
67 PRR3interactor21.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
68 PTPN7oncoprotein100Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
69 RAB3IL1interactor3034.540Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
70 RBCK1interactor80.524105.119GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
71 RFT1interactor21.0000Rft-1 (PF04506, IPR007594): Rft protein
72 RNF166interactor30.33337.366zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
73 RNF31interactor90.67996.909Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
PUB (PF09409, IPR018997): PUB domain
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
74 ROBO3interactor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
75 SDCBPinteractor30.33380.923PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
76 SFI1interactor31.0000HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
IncA (PF04156, IPR007285): IncA protein
77 SHARPINinteractor61.0000DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
78 SIRPAinteractor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
DUF4448 (PF14610, IPR028000): Protein of unknown function (DUF4448)
G6B (PF15096, IPR028070): G6B family
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
79 SKIoncoprotein200c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
80 SLTMinteractor100DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Podoplanin (PF05808, IPR008783): Podoplanin
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
81 SPATS2interactor2061.149DUF1296 (PF06972, IPR009719): Protein of unknown function (DUF1296)
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
82 SPATS2Linteractor100DUF1296 (PF06972, IPR009719): Protein of unknown function (DUF1296)
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
83 SPC25interactor30.33355.510Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spindle_Spc25 (PF08234, IPR013255): Chromosome segregation protein Spc25
84 TAOK2interactor100Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
Pkinase (PF00069, IPR000719): Protein kinase domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
85 TBC1D22Binteractor21.0000RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
86 TBC1D31interactor40.83323.037Neisseria_PilC (PF05567, IPR008707): Neisseria PilC beta-propeller domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nbas_N (PF15492, IPR029145): Neuroblastoma-amplified sequence, N terminal
87 TCHPsuppressor30.66723.037TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
TPH (PF13868): Trichohyalin-plectin-homology domain
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
88 THAP3interactor100Pfg27 (PF09216, IPR015299): Pfg27
THAP (PF05485, IPR006612, SM00980): THAP domain
89 TIGD5interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
90 TMEM100interactor100TMEM100 (PF16311, IPR032536): Transmembrane protein 100
91 TNFRSF10Bsuppressor30.66713.668Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
92 TNFSF14interactor50.9000.400TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
93 TNIKinteractor21.0000CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
94 TRAF1oncoprotein190.255699.625HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
95 TRAF2interactor260.1501353.493MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
96 TRAF3oncoprotein110.53331.908ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
97 TRAF4oncoprotein60.400118.571MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
98 TRAF5interactor70.66711.840Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
99 TRIM37oncoprotein150.176679.582MATH (PF00917, IPR002083, SM00061): MATH domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
DUF5071 (PF16804, IPR031837): Domain of unknown function (DUF5071)
100 TRIM4protein found in more fusions200SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Fasciclin (PF02469, IPR000782, SM00554): Fasciclin domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
101 TSGA10IPinteractor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
102 UBBinteractor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
103 USP15oncoprotein60.100172.532UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
104 USP2interactor50.200206.597UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
105 UTP14Cinteractor100Utp14 (PF04615, IPR006709): Utp14 protein
106 VAPAinteractor21.0000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
107 VAPBinteractor40.5003.000ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
108 XRCC6oncoprotein3045.968Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
109 ZC3H3interactor20117.933zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
110 ZFC3H1interactor2073.364Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF2277 (PF10041, IPR018735): Uncharacterized conserved protein (DUF2277)
zf-C3H1 (PF10650, IPR019607, SM00356): Putative zinc-finger domain
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
111 ZGPATinteractor40.33377.614Agenet (PF05641, IPR008395, SM00743): Agenet domain
G-patch (PF01585, IPR000467, SM00443): G-patch domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
112 ZMAT2interactor30.33359.483Cgr1 (PF03879, IPR005579): Cgr1 family
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
113 ZMYM6interactor100Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
YHS (PF04945, IPR007029): YHS domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zinc_ribbon_5 (PF13719, IPR011723): zinc-ribbon domain
DUF4371 (PF14291, IPR025398): Domain of unknown function (DUF4371)
114 ZMYND11suppressor60.9001.087DUF1002 (PF06207, IPR009343): Protein of unknown function (DUF1002)
DUF1353 (PF07087, IPR010767): Protein of unknown function (DUF1353)
PWWP (PF00855, IPR000313, SM00293): PWWP domain
zf-MYND (PF01753, IPR002893): MYND finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
115 ZNF417interactor30.33354.596A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
116 ZNF724interactor100NA
117 ZNF865interactor100Chorion_2 (PF03964, IPR005649): Chorion family 2
DUF1633 (PF07794, IPR012436): Protein of unknown function (DUF1633)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
118 ZWINTinteractor31.0000Zwint (PF15556, IPR029092): ZW10 interactor

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