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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins17 (28.33 %)
The number (and %) of the tumor suppressors6 (10.00 %)
Total number of binary PPIs (saturation %)166 (9.38 %)
The number (and %) of affected PPIs58 (34.94 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI4.733
Assortativity coefficient-0.2315
The network average Clustering coefficient0.467
The number (and %) of a zero Clustering coefficients15 (25.00 %)
The number (and %) of a zero Betweenness Centrality23 (38.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RAB14,CUEDC1 All fusions
Proteins found in more fusions OPTN (see 1 fusions); CUL7 (see 2 fusions); NEDD4L (see 4 fusions); APP (see 5 fusions); EXOC5 (see 1 fusions); RAB11FIP1 (see 2 fusions); ATP6V1C1 (see 3 fusions); SMURF2 (see 1 fusions); VCP (see 4 fusions); RPA1 (see 1 fusions); MAP3K1 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAB14parental protein430.0682360.173Ras (PF00071, IPR001806, SM00173): Ras family
2 CUEDC1parental protein150.133568.210CUE (PF02845, IPR003892, SM00546): CUE domain
3 ABCC2interactor21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805)
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
4 ACTL6Ainteractor100Actin (PF00022, IPR004000, SM00268): Actin
5 APPprotein found in more fusions100.194226.229APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARRDC1interactor40.333156.275Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATF2oncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
8 ATL3interactor40.33361.754GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
9 ATP6AP2interactor40.6671.000Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
10 ATP6V1C1protein found in more fusions40.6672.443V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
11 CCDC8interactor100.472283.577Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
12 CDC42oncoprotein50.6672.000Ras (PF00071, IPR001806, SM00173): Ras family
13 CUL7protein found in more fusions90.64310.239ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
14 DGUOKinteractor31.0000dNK (PF01712, IPR002624): Deoxynucleoside kinase
15 DSTYKinteractor100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
16 DUSP19interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
17 EEDsuppressor50.8330.222WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 EXOC5protein found in more fusions31.0000Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
19 FAM189A2interactor40.33378.377CD20 (PF04103, IPR007237): CD20-like family
20 GDI1interactor40.6672.000GDI (PF00996, IPR018203): GDP dissociation inhibitor
21 HAX1interactor50.400176.308Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
22 HNRNPFinteractor100.51119.595RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
23 HSPA5oncoprotein140.48748.052HSP70 (PF00012, IPR013126): Hsp70 protein
24 IFI16suppressor30.6673.733HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
25 IKBKGinteractor40.33347.517CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
26 ILF3oncoprotein90.58313.793dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
27 ILVBLinteractor30.6672.443TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
28 IQCB1interactor50.6006.832DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
29 LAMTOR3interactor100MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
30 LDLRAD4interactor40.66715.557Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
31 MAP3K1oncoprotein31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
32 NEDD4suppressor80.33332.948Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
33 NEDD4Lsuppressor90.179368.847WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
34 NFKBIAoncoprotein40.333131.291Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
35 NUFIP1interactor100NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
36 OCRLinteractor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
OCRL_clath_bd (PF16726, IPR031995): Inositol polyphosphate 5-phosphatase clathrin binding domain
37 OIP5interactor100Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
38 OPTNprotein found in more fusions30119.932ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
39 RAB11FIP1protein found in more fusions3096.517C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
SOUL (PF04832, IPR006917): SOUL heme-binding protein
Latarcin (PF10279, IPR018802): Latarcin precursor
40 RAB11FIP5interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
RBD-FIP (PF09457, IPR019018): FIP domain
41 RAB4Boncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
42 RBSNinteractor100DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Histone_HNS (PF00816, IPR001801): H-NS histone family
zf-AD (PF07776, IPR012934, SM00868): Zinc-finger associated domain (zf-AD)
Rbsn (PF11464, IPR021565): Rabenosyn Rab binding domain
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
43 RPA1suppressor100.69411.027Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
44 RPA2oncoprotein70.7147.562RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
45 RPA3interactor80.7145.222Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
46 RUFY1interactor31.0000DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
47 SDHAsuppressor21.0000FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
48 SLC25A41interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
49 SLC33A1interactor21.0000Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
50 SMURF2protein found in more fusions41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
51 SRPRBinteractor40176.152MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
52 TACC3oncoprotein100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
53 TGOLN2interactor21.0000MSA_2 (PF00985, IPR001136): Merozoite Surface Antigen 2 (MSA-2) family
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
TUTF7_u4 (PF16631): Unstructured region 4 on terminal uridylyltransferase 7
54 TMEM51interactor30.6671.945WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
TMEM51 (PF15345, IPR029265): Transmembrane protein 51
55 TMEM92interactor30.6671.945WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
56 UBL4Ainteractor80.32192.224ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
57 UNKinteractor50.5005.000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
58 UQCRFS1interactor40.5003.000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
59 VCPprotein found in more fusions80.476194.059AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
60 ZNF114interactor200HNH (PF01844, IPR002711): HNH endonuclease
KRAB (PF01352, IPR001909, SM00349): KRAB box
PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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