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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LRP2, ATP9B (from a repository: Fri Aug 16 08:23:28 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins6 (15.00 %)
The number (and %) of the tumor suppressors4 (10.00 %)
Total number of binary PPIs (saturation %)68 (8.72 %)
The number (and %) of affected PPIs38 (55.88 %)
The number of possible different fusions7
PPI diameter2
PPI radiusinf
The average degree of PPI2.950
Assortativity coefficient-0.2264
The network average Clustering coefficient0.503
The number (and %) of a zero Clustering coefficients17 (42.50 %)
The number (and %) of a zero Betweenness Centrality35 (87.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LRP2,ATP9B All fusions
Proteins found in more fusions ATN1 (see 1 fusions); CLU (see 5 fusions); APOE (see 1 fusions); APP (see 5 fusions); DLG4 (see 1 fusions); GC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LRP2parental protein380.0301269.667Arylesterase (PF01731, IPR002640): Arylesterase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Form-deh_trans (PF09163, IPR015246): Formate dehydrogenase N, transmembrane
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
2 ATP9Binteractor000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
GNVR (PF13807, IPR032807): G-rich domain on putative tyrosine kinase
PhoLip_ATPase_N (PF16209, IPR032631): Phospholipid-translocating ATPase N-terminal
PhoLip_ATPase_C (PF16212, IPR032630): Phospholipid-translocating P-type ATPase C-terminal
3 ANAPC10interactor21.0000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
4 ANKRA2interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 ANKS1Binteractor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
6 APBA2interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
7 APOEprotein found in more fusions200Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
8 APOHinteractor100Sushi_2 (PF09014, IPR015104): Beta-2-glycoprotein-1 fifth domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
9 APPprotein found in more fusions160.15288.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10 ATN1protein found in more fusions31.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
11 CLUsuppressor40.6671.000Clusterin (PF01093, IPR000753): Clusterin
12 DAB1interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
13 DAB2suppressor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
14 DLG2interactor21.0000Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein
L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
15 DLG3interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 DLG4protein found in more fusions40.6671.000L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17 GCprotein found in more fusions200VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
18 GIPC1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
19 ITGB1BP1interactor21.0000ICAP-1_inte_bdg (PF10480, IPR019517): Beta-1 integrin binding protein
20 LDLRAP1interactor100PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
21 LPAinteractor100Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
22 LPLinteractor31.0000Lipase (PF00151, IPR013818): Lipase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
23 LRP2BPinteractor100PPR (PF01535, IPR002885): PPR repeat
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
24 LRPAP1interactor100Alpha-2-MRAP_C (PF06401, IPR010483): Alpha-2-macroglobulin RAP, C-terminal domain
Alpha-2-MRAP_N (PF06400, IPR009066): Alpha-2-macroglobulin RAP, N-terminal domain
25 MAGI1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_C58 (PF03543, IPR006473): Yersinia/Haemophilus virulence surface antigen
Serglycin (PF04360, IPR007455): Serglycin
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
PDZ_2 (PF13180, IPR001478): PDZ domain
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
DUF4770 (PF15994, IPR031935): Domain of unknown function (DUF4770)
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
26 MAPK8IP1oncoprotein41.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 MAPK8IP2interactor60.6003.667BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
28 NOS1APinteractor21.0000Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
29 OBP2Ainteractor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
30 PLAUinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
31 PRSS23interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
32 RBP1suppressor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
33 RNASE13interactor21.0000RnaseA (PF00074, IPR023412, SM00092): Pancreatic ribonuclease
34 SCGB1A1interactor100Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
35 SCN3Ainteractor100ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
Ion_trans (PF00520, IPR005821): Ion transport protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Na_trans_cytopl (PF11933, IPR024583): Cytoplasmic domain of voltage-gated Na+ ion channel
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
36 SNX17interactor21.0000FERM_M (PF00373, IPR019748): FERM central domain
PX (PF00787, IPR001683, SM00312): PX domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
37 SYNJ2BPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
38 THBS1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EndIII_4Fe-2S (PF10576, IPR003651): Iron-sulfur binding domain of endonuclease III
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
39 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
40 ZFP41interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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