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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)77
The number (and %) of the onco-proteins26 (33.77 %)
The number (and %) of the tumor suppressors7 (9.09 %)
Total number of binary PPIs (saturation %)317 (10.83 %)
The number (and %) of affected PPIs75 (23.66 %)
The number of possible different fusions14
PPI diameter2
PPI radiusinf
The average degree of PPI7.506
Assortativity coefficient-0.3436
The network average Clustering coefficient0.514
The number (and %) of a zero Clustering coefficients10 (12.99 %)
The number (and %) of a zero Betweenness Centrality22 (28.57 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LGALS1,PIGL All fusions
Proteins found in more fusions LGALS3 (see 2 fusions); PCBP2 (see 3 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); ALDOA (see 2 fusions); RAC1 (see 2 fusions); LGALS3BP (see 2 fusions); MEIS2 (see 1 fusions); UBE2N (see 1 fusions); MYC (see 2 fusions); HNRNPL (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LGALS1parental protein740.0794022.342Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
2 PIGLparental protein100PIG-L (PF02585, IPR003737): GlcNAc-PI de-N-acetylase
3 ACO1interactor30.6670.667Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
4 ALDOAprotein found in more fusions110.37820.201Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
5 ANXA11interactor50.6001.153Annexin (PF00191, IPR018502, SM00335): Annexin
6 ANXA2interactor180.43851.072Annexin (PF00191, IPR018502, SM00335): Annexin
7 APEX1interactor40.5001.583Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
8 ARF4interactor80.35710.183Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
9 ATP6AP2interactor200Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
10 CD2interactor21.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
11 CD4suppressor50.6671.333ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
12 CD68oncoprotein21.0000Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
13 CD7interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
14 CDC42oncoprotein60.5003.019Ras (PF00071, IPR001806, SM00173): Ras family
15 CHORDC1interactor41.0000CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
16 CLNS1Ainteractor70.5246.333Voldacs (PF03517): Regulator of volume decrease after cellular swelling
17 CRIP1interactor50.7001.500LIM (PF00412, IPR001781, SM00132): LIM domain
18 DBN1oncoprotein90.6676.483Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
19 DDX19Binteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
20 EGFRoncoprotein100.33317.936Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
21 EREGinteractor21.0000CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
EGF (PF00008, IPR000742, SM00181): EGF-like domain
22 FLNAsuppressor130.59019.106CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
23 FN1oncoprotein280.243199.916fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
24 FUBP1oncoprotein160.36752.757DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
25 GEMIN2interactor31.0000SIP1 (PF04938): Survival motor neuron (SMN) interacting protein 1 (SIP1)
Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
26 GEMIN4interactor90.35715.233NA
27 GOLT1Binteractor50.5004.333Got1 (PF04178, IPR007305): Got1/Sft2-like family
28 GTF2Iinteractor30.6670.333GTF2I (PF02946, IPR004212): GTF2I-like repeat
29 HEPACAM2interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
PgaD (PF13994, IPR023829): PgaD-like protein
30 HIST1H2BOinteractor40.8330.286Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
31 HNRNPLprotein found in more fusions100.5837.190RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
32 HRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
33 HSPA5oncoprotein120.43617.833HSP70 (PF00012, IPR013126): Hsp70 protein
34 HSPB2interactor31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
35 ICAM2interactor100ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
36 IGBP1interactor60.4006.119TAP42 (PF04177, IPR007304): TAP42-like family
37 ITGA4interactor190.49732.065FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
38 LASP1oncoprotein30.6670.200LIM (PF00412, IPR001781, SM00132): LIM domain
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 LGALS3oncoprotein150.22057.967Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
40 LGALS3BPoncoprotein70.4674.300BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
41 LIMA1suppressor100.42215.719LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
42 LMAN1interactor30.6670.333Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
43 MCM2oncoprotein250.337122.418AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
44 MCM5oncoprotein110.7097.756MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
45 MEIS2protein found in more fusions200Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
46 MUC16oncoprotein30.6670.667Phage_DNA_bind (PF02303, IPR003512): Helix-destabilising protein
SEA (PF01390, IPR000082, SM00200): SEA domain
Mersacidin (PF16934, IPR027632): Two-component Enterococcus faecalis cytolysin (EFC)
47 MYConcoprotein120.27326.906HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
48 MYH9suppressor120.6678.572IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
49 NLGN3interactor30.6671.000COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
50 NPM1suppressor140.47425.791Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
51 PCBP1oncoprotein150.39039.481Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
52 PCBP2protein found in more fusions120.6558.642Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
53 PHB2interactor110.45520.257DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
54 PLIN3interactor60.6002.167Perilipin (PF03036, IPR004279): Perilipin family
55 PSG1interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
56 PSMG1interactor50.5002.167PAC1 (PF16094, IPR016565): Proteasome assembly chaperone 4
57 PTENsuppressor60.5336.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
58 PTGER3interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
FtsX (PF02687, IPR003838): FtsX-like permease family
59 PTPRCsuppressor50.4005.500fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PTP_N (PF12453, IPR024739): Protein tyrosine phosphatase N terminal
CD45 (PF12567, IPR016335): Leukocyte receptor CD45
SCIMP (PF15050, IPR028181): SCIMP protein
60 RAB10oncoprotein41.0000Ras (PF00071, IPR001806, SM00173): Ras family
61 RAB5Concoprotein80.5367.868Ras (PF00071, IPR001806, SM00173): Ras family
62 RAC1oncoprotein110.37817.634Ras (PF00071, IPR001806, SM00173): Ras family
63 RAE1interactor50.4004.500Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
64 SERPINH1interactor50.5001.983Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
65 SLAMF1interactor31.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
SLAM (PF06214, IPR010407): Signaling lymphocytic activation molecule (SLAM) protein
66 SLAMF7interactor200V-set (PF07686, IPR013106): Immunoglobulin V-set domain
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
Ig_3 (PF13927): Immunoglobulin domain
67 SMN1interactor80.38111.222SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
68 SNRPBinteractor50.6002.567LSM (PF01423, IPR001163): LSM domain
69 SOD1interactor60.6002.500Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
70 SPNinteractor100BatA (PF07584, IPR024163): Aerotolerance regulator N-terminal
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
71 SUSD2interactor100AMOP (PF03782, IPR005533, SM00723): AMOP domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
72 TALDO1interactor60.6002.860TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
73 U2AF2protein found in more fusions130.37924.830RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
74 UBE2Nprotein found in more fusions50.5000.803UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
75 UQCRFS1interactor21.0000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
76 USP4oncoprotein40.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
77 VCAM1interactor180.41241.414C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain

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