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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LFNG, ARHGAP32 (from a repository: Thu May 23 10:27:24 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins20 (45.45 %)
The number (and %) of the tumor suppressors5 (11.36 %)
Total number of binary PPIs (saturation %)191 (20.19 %)
The number (and %) of affected PPIs42 (21.99 %)
The number of possible different fusions13
PPI diameter4
PPI radius2
The average degree of PPI7.636
Assortativity coefficient-0.2254
The network average Clustering coefficient0.567
The number (and %) of a zero Clustering coefficients3 (6.82 %)
The number (and %) of a zero Betweenness Centrality9 (20.45 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LFNG,ARHGAP32 All fusions
Proteins found in more fusions SFN (see 1 fusions); HNRNPD (see 1 fusions); SHC1 (see 1 fusions); APP (see 4 fusions); AES (see 3 fusions); ATXN1 (see 3 fusions); GRB2 (see 1 fusions); RAC1 (see 1 fusions); GAB2 (see 3 fusions); FYN (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LFNGparental protein40.6671.508Fringe (PF02434, IPR003378): Fringe-like
2 ARHGAP32parental protein380.149963.743PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
3 ABI2suppressor60.4005.864Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 AESprotein found in more fusions40.6670.667TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
5 APPprotein found in more fusions80.19036.605APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARRB1interactor40.6671.367Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATXN1protein found in more fusions50.5002.400AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 BCAR1oncoprotein110.43622.701Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
9 CCT2interactor80.50028.401Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT6Ainteractor60.60011.702Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CCT7interactor80.42929.426Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CDC42oncoprotein50.6671.548Ras (PF00071, IPR001806, SM00173): Ras family
13 CRKoncoprotein110.60015.567SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 CRKLoncoprotein100.7116.061SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
15 DZIP3interactor40.6671.743DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
16 EGFRoncoprotein180.37593.134Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17 FYNoncoprotein70.5336.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
18 FZR1suppressor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
19 GAB1oncoprotein100.8671.440PH (PF00169, IPR001849, SM00233): PH domain
20 GAB2oncoprotein120.7275.051PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
21 GRB2oncoprotein210.368134.391SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
22 GRIN2Binteractor21.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
NMDAR2_C (PF10565, IPR018884): N-methyl D-aspartate receptor 2B3 C-terminus
23 HNRNPDoncoprotein80.5245.436CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 LZTS2suppressor40.5003.792CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
25 MDFIinteractor200MDFI (PF15316, IPR026134): MyoD family inhibitor
26 NCK1oncoprotein70.6674.344SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 NCK2interactor60.5004.367SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
28 NPHP1interactor31.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
29 NTRK1oncoprotein200.351127.894I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
30 NXF1interactor100.27834.992NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
31 PIK3R1oncoprotein140.66715.044RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
32 PLCG1oncoprotein110.56415.351C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
33 RAC1oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
34 RHOAsuppressor30.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
35 SFNsuppressor70.6002.89314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
36 SGTBinteractor100TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
37 SHC1oncoprotein150.52758.926PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
38 SHC2interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
39 SHC3interactor31.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
40 SMURF1interactor100.27854.589C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
41 SORT1interactor31.0000Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
42 SRConcoprotein120.60015.304Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
43 SYNCRIPinteractor80.50016.141RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
44 ZWINTinteractor304.941Zwint (PF15556, IPR029092): ZW10 interactor

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