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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LAMA5, ADRM1 (from a repository: Mon Aug 26 11:22:46 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)77
The number (and %) of the onco-proteins20 (25.97 %)
The number (and %) of the tumor suppressors4 (5.19 %)
Total number of binary PPIs (saturation %)1096 (37.46 %)
The number (and %) of affected PPIs75 (6.84 %)
The number of possible different fusions14
PPI diameter5
PPI radius3
The average degree of PPI27.688
Assortativity coefficient-0.0209
The network average Clustering coefficient0.666
The number (and %) of a zero Clustering coefficients11 (14.29 %)
The number (and %) of a zero Betweenness Centrality15 (19.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LAMA5,ADRM1 All fusions
Proteins found in more fusions PSMB3 (see 1 fusions); PARK2 (see 1 fusions); UBE3A (see 1 fusions); UBQLN1 (see 2 fusions); PSMB7 (see 2 fusions); PSMA7 (see 5 fusions); UBC (see 7 fusions); APP (see 5 fusions); SMAD2 (see 2 fusions); HUWE1 (see 4 fusions); FKBP8 (see 1 fusions); EGFR (see 2 fusions); PSMC5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LAMA5parental protein150.0101174.768DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
2 ADRM1parental protein600.543638.880Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
3 APPprotein found in more fusions180.50085.471APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATP6V0D2interactor100vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
5 BAG1oncoprotein60.9330.065BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
6 BCAMinteractor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
7 BIRC2oncoprotein41.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 CCDC74Binteractor201.0000CCDC92 (PF14916): Coiled-coil domain of unknown function
CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
9 CCDC92interactor171.0000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
CCDC92 (PF14916): Coiled-coil domain of unknown function
10 COL7A1oncoprotein100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
DUF4249 (PF14054, IPR025345): Domain of unknown function (DUF4249)
DUF4992 (PF16383, IPR032155): Domain of unknown function
11 CRKLoncoprotein30.33333.273SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 DAG1interactor100DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
13 EGFRoncoprotein160.400206.517Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 FBLN2interactor200ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Metallothio_6 (PF05522, IPR017980): Metallothionein
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
15 FBXO6interactor150.667573.212FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
16 FKBP8protein found in more fusions330.88157.842FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
17 HUWE1oncoprotein370.751175.952BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
18 INSIG2interactor150.9141.379INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
19 LAMC1interactor40.33385.908BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_I (PF06008, IPR009254): Laminin Domain I
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
20 MEP1Ainteractor200Astacin (PF01400, IPR001506): Astacin (Peptidase family M12A)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
21 MX1interactor31.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
22 MYOCinteractor200IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
23 PAAF1interactor220.9780.363WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
24 PARK2suppressor420.79835.968IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 PIPSLinteractor100NA
26 PPP1R2P4interactor41.0000NA
27 PSMA1interactor440.83742.560Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
28 PSMA2interactor450.84715.545Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
29 PSMA3interactor440.83560.215Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
30 PSMA4interactor390.91827.240Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
31 PSMA5oncoprotein400.89211.840Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
32 PSMA6interactor440.83060.114Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
33 PSMA7protein found in more fusions450.81536.822Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
34 PSMB1interactor400.9087.248Proteasome (PF00227, IPR001353): Proteasome subunit
35 PSMB2interactor390.9274.816Proteasome (PF00227, IPR001353): Proteasome subunit
36 PSMB3protein found in more fusions390.9305.466Proteasome (PF00227, IPR001353): Proteasome subunit
37 PSMB4interactor380.9226.962Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
38 PSMB5interactor380.9532.372Proteasome (PF00227, IPR001353): Proteasome subunit
39 PSMB6interactor370.9611.993DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
40 PSMB7protein found in more fusions410.9186.006Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
41 PSMB8interactor350.9791.079Proteasome (PF00227, IPR001353): Proteasome subunit
42 PSMC1interactor530.673129.514AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
43 PSMC2interactor510.73480.671AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
44 PSMC3interactor490.76168.035AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
45 PSMC4interactor460.81719.883AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
46 PSMC5protein found in more fusions510.714229.097AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
47 PSMC6interactor500.72380.132AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
48 PSMD1interactor500.72275.151PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
49 PSMD10interactor260.9202.566Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
50 PSMD11interactor510.670270.640DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
51 PSMD12interactor480.79625.132Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
52 PSMD13interactor480.73066.419Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
53 PSMD14interactor500.74042.714JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
54 PSMD2oncoprotein490.71774.512PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
55 PSMD3interactor490.71788.605Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
56 PSMD4interactor510.700110.864UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
57 PSMD6interactor450.81421.716RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
58 PSMD7interactor450.82644.780JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
59 PSMD8interactor460.76489.748CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
60 PSME1interactor270.8894.884PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
61 PTPRKsuppressor40.33380.257fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
62 RAD23Aoncoprotein420.84316.755UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
63 RAD23Bsuppressor230.8186.981K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
64 RNASEH2Ainteractor100RNase_HII (PF01351, IPR024567): Ribonuclease HII
65 RPS21interactor140.8243.019Ribosomal_S21e (PF01249, IPR001931): Ribosomal protein S21e
66 RPS8interactor120.9090.820Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
67 SHFM1interactor360.76728.371CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
68 SMAD2suppressor50.500150.071MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
69 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
70 TMEM25interactor2012.707C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
71 TXNL1interactor230.85812.509PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
72 UBCprotein found in more fusions420.680129.730ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
73 UBE3Aoncoprotein160.8193.268HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
74 UBQLN1protein found in more fusions180.7355.561Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
75 UCHL5oncoprotein500.693158.936Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
76 USP14interactor280.9054.541UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
77 USP4oncoprotein70.667183.535UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

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