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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAP3K15, SLC12A2 (from a repository: Thu Dec 13 23:30:47 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins9 (31.03 %)
The number (and %) of the tumor suppressors1 (3.45 %)
Total number of binary PPIs (saturation %)60 (14.78 %)
The number (and %) of affected PPIs28 (46.67 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI3.103
Assortativity coefficient-0.3397
The network average Clustering coefficient0.336
The number (and %) of a zero Clustering coefficients15 (51.72 %)
The number (and %) of a zero Betweenness Centrality18 (62.07 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC12A2,MAP3K15 All fusions
Proteins found in more fusions ILK (see 1 fusions); EGFR (see 2 fusions); SLC12A2 (see 1 fusions); CUL7 (see 2 fusions); HSP90AA1 (see 5 fusions); LGALS3 (see 2 fusions); COMMD1 (see 1 fusions); MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC12A2parental protein240.051587.986AA_permease (PF00324, IPR004841): Amino acid permease
AA_permease_N (PF08403, IPR013612): Amino acid permease N-terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SLC12 (PF03522, IPR018491): Solute carrier family 12
2 MAP3K15parental protein40110.733Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
MCM_N (PF14551, IPR027925): MCM N-terminal domain
3 AK1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ADK (PF00406, IPR000850): Adenylate kinase
4 ATP4Ainteractor3032.357Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 CCDC8interactor41.0000Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
6 CDKN2AIPinteractor100XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
7 COMMD1protein found in more fusions31.0000COMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
8 CUL7protein found in more fusions60.40057.381ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
9 EGFRoncoprotein80.28669.348Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
10 FAM189A2interactor100CD20 (PF04103, IPR007237): CD20-like family
11 GNG12interactor100G-gamma (PF00631, IPR015898, SM00224): GGL domain
12 HSP90AA1oncoprotein50.16790.262HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
13 ILKsuppressor3025.090Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
14 LGALS3oncoprotein50.6675.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
15 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
16 LGALS9interactor31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
17 LGALS9Cinteractor31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 MAPK14oncoprotein60.5009.281Pkinase (PF00069, IPR000719): Protein kinase domain
19 MCOLN3interactor100PKD_channel (PF08016, IPR013122): Polycystin cation channel
20 NTRK1oncoprotein40.66725.090I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 PRKAB2interactor200AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
22 RAB10oncoprotein3059.471Ras (PF00071, IPR001806, SM00173): Ras family
23 SEC13interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
24 STK39interactor31.0000BASP1 (PF05466, IPR008408): Brain acid soluble protein 1 (BASP1 protein)
FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
25 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
26 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
27 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
28 TNFSF13Boncoprotein200TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
29 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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