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Fusion ID: Protein names:	388815 55975
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Visualization interactions

Cytoscape Web for: parental proteins MIR99AHG, KLHL7 (from a repository: Tue May 2 13:16:36 2017)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	15
The number (and %) of the onco-proteins	5 (33.33 %)
The number (and %) of the tumor suppressors	1 (6.67 %)
Total number of binary PPIs (saturation %)	37 (35.24 %)
The number (and %) of affected PPIs	14 (37.84 %)
The number of possible different fusions	5
PPI diameter	2
PPI radius	inf
The average degree of PPI	3.733
Assortativity coefficient	-0.4492
The network average Clustering coefficient	0.519
The number (and %) of a zero Clustering coefficients	5 (33.33 %)
The number (and %) of a zero Betweenness Centrality	8 (53.33 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: KLHL7,MIR99AHG	All fusions
Proteins found in more fusions	NUP153 (see 2 fusions); CUL3 (see 1 fusions); UBC (see 1 fusions); YWHAZ (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	KLHL7	parental protein	14	0.192	108.500	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_6 (PF13964): Kelch motif
2	MIR99AHG	interactor	0	0	0	NA
3	BOD1L1	interactor	2	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif COMPASS-Shg1 (PF05205): COMPASS (Complex proteins associated with Set1p) component shg1 DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) YqfQ (PF14181, IPR025571): YqfQ-like protein
4	CARNMT1	interactor	1	0	0	N2227 (PF07942, IPR012901): N2227-like protein RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
5	CKAP5	interactor	2	0	0	HEAT (PF02985, IPR000357): HEAT repeat PAS_6 (PF08348, IPR013559): YheO-like PAS domain UME (PF08064, IPR012993, SM00802): UME (NUC010) domain CLASP_N (PF12348, IPR024395): CLASP N terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
6	CUL3	protein found in more fusions	9	0.500	12.500	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7	FERMT3	interactor	1	0	0	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
8	MOV10	interactor	4	1.000	0	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
9	NR2C2	suppressor	2	0	0	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
10	NUP153	protein found in more fusions	5	0.833	0.667	Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
11	NUP50	interactor	4	0.667	2.000	NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa) Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
12	NXF1	interactor	6	0.800	1.333	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
13	RBX1	oncoprotein	3	1.000	0	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
14	UBC	protein found in more fusions	6	0.900	0.500	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
15	YWHAZ	protein found in more fusions	6	0.900	0.500	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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