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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins17 (25.00 %)
The number (and %) of the tumor suppressors9 (13.24 %)
Total number of binary PPIs (saturation %)245 (10.76 %)
The number (and %) of affected PPIs66 (26.94 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI6.529
Assortativity coefficient-0.2791
The network average Clustering coefficient0.488
The number (and %) of a zero Clustering coefficients11 (16.18 %)
The number (and %) of a zero Betweenness Centrality17 (25.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SNX6,KLK2 All fusions
Proteins found in more fusions IMPDH2 (see 2 fusions); APEH (see 1 fusions); APP (see 4 fusions); NDEL1 (see 1 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); EGFR (see 2 fusions); VPS35 (see 2 fusions); STAT1 (see 1 fusions); SNX1 (see 1 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SNX6parental protein550.0862470.094PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
2 KLK2parental protein110.055694.409Trypsin (PF00089, IPR001254, SM00020): Trypsin
3 ACVR2Binteractor40.6671.333Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
4 ACVRL1interactor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
5 ADAMTS1oncoprotein100ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
6 ANP32Einteractor50.9000.286BUD22 (PF09073, IPR015158): BUD22
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
7 APEHoncoprotein70.66760.807Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
8 APLP2interactor3035.223APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
ELM2 (PF01448, IPR000949): ELM2 domain
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
Usp (PF00582, IPR006016): Universal stress protein family
YL1 (PF05764, IPR008895): YL1 nuclear protein
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
9 APPprotein found in more fusions180.088619.226APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10 ATG7interactor90.61136.173ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
11 ATP6V1C1protein found in more fusions140.57715.310V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
12 BMPR1Binteractor306.375Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
13 BRCA1suppressor80.238103.621BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
14 BRMS1suppressor306.375Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
Sds3 (PF08598, IPR013907): Sds3-like
15 CALM1interactor60.40038.818EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
16 CAMKMTinteractor40.5008.038Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
17 CCNL2interactor30.6671.000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
18 COILinteractor50.6677.042CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
19 CSNK2A2interactor50.40037.910Pkinase (PF00069, IPR000719): Protein kinase domain
20 DISC1interactor30.6671.569HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
21 DNM3interactor31.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
22 EGFRoncoprotein110.40053.222Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
23 ELAVL1oncoprotein130.136258.370RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 ESR1suppressor80.33341.401Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
25 FAM129Binteractor90.6397.858PH (PF00169, IPR001849, SM00233): PH domain
26 FAM221Ainteractor21.0000FAM221 (PF14753, IPR026755): Protein FAM221A/B
27 FAM43Ainteractor100PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
28 GATSinteractor21.0000ACT_7 (PF13840, IPR027795): ACT domain
29 GIT1interactor31.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
30 GLG1interactor21.0000BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat
31 GTF2A1oncoprotein50.7001.317TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
32 H3F3Aoncoprotein90.47281.270Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33 HERC2interactor40.6670.667ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
34 IFI16suppressor60.40022.061HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
35 IMPDH2protein found in more fusions41.0000IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
36 INSRinteractor40.8330.400fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
37 LEPRoncoprotein40.8330.400fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
38 NDEL1protein found in more fusions40.33322.011HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
39 PAWRsuppressor100.6898.922ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
40 PCID2interactor60.5336.512PCI (PF01399, IPR000717, SM00088): PCI domain
41 PDGFRAoncoprotein80.5717.077Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
42 PHLPP1suppressor30.6674.833LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PRIMA1 (PF16101): Proline-rich membrane anchor 1
43 PIM1oncoprotein60.40015.080Pkinase (PF00069, IPR000719): Protein kinase domain
44 RNF2interactor90.179205.137zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
45 RTF1interactor30.3338.751K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Plus-3 (PF03126, IPR004343): Plus-3 domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
YL1 (PF05764, IPR008895): YL1 nuclear protein
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
46 SERPINA3interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
47 SERPINA5interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
48 SERPINB6interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
49 SERPINE2interactor3046.315Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
50 SERPINF2interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
51 SHMT1interactor120.60015.560SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
52 SHMT2interactor140.38574.568SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
53 SNX1protein found in more fusions160.381116.637PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
54 SNX2interactor270.214260.830PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
55 SNX4interactor60.6672.833PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
56 STAT1suppressor160.40063.950SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
57 SUZ12suppressor60.30057.821DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
58 TEAD4interactor100TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
59 TGFBR1oncoprotein40.5009.027Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
60 TGFBR2suppressor50.30026.684ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
61 TNIKinteractor21.0000CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
62 TREML2interactor21.0000Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
63 TSNprotein found in more fusions80.7144.341Translin (PF01997, IPR002848): Translin family
64 TSNAXinteractor30.6670.333Translin (PF01997, IPR002848): Translin family
65 USP46interactor30.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
66 VAPBinteractor21.0000ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
67 VPS29interactor120.60653.689Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
68 VPS35protein found in more fusions130.45563.513FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35

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