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Fusion ID: Protein names:	3815 4294900001
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Visualization interactions

Cytoscape Web for: parental proteins KIT, AC073283.3 (from a repository: Wed Mar 11 17:01:57 2020)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	44
The number (and %) of the onco-proteins	23 (52.27 %)
The number (and %) of the tumor suppressors	8 (18.18 %)
Total number of binary PPIs (saturation %)	193 (20.40 %)
The number (and %) of affected PPIs	42 (21.76 %)
The number of possible different fusions	10
PPI diameter	2
PPI radius	inf
The average degree of PPI	8.000
Assortativity coefficient	-0.2823
The network average Clustering coefficient	0.594
The number (and %) of a zero Clustering coefficients	5 (11.36 %)
The number (and %) of a zero Betweenness Centrality	13 (29.55 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: AC073283.3,KIT	All fusions
Proteins found in more fusions	PTPN11 (see 1 fusions); GRB2 (see 1 fusions); LCK (see 1 fusions); SH3KBP1 (see 1 fusions); STAT5B (see 1 fusions); LYN (see 2 fusions); CBLB (see 4 fusions); PIK3R1 (see 1 fusions); STAT1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AC073283.3	interactor	0	0	0	NA
2	KIT	parental protein	42	0.156	1050.358	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
3	BCR	oncoprotein	10	0.600	9.785	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain IQ_SEC7_PH (PF16453, IPR001849): PH domain
4	CBL	suppressor	20	0.433	56.812	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
5	CBLB	oncoprotein	11	0.800	3.053	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1
6	CD63	interactor	3	1.000	0	Tetraspannin (PF00335, IPR018499): Tetraspanin family DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
7	CD81	interactor	5	0.667	2.000	Tetraspannin (PF00335, IPR018499): Tetraspanin family
8	CD9	oncoprotein	3	1.000	0	Tetraspannin (PF00335, IPR018499): Tetraspanin family
9	CLTC	oncoprotein	5	0.700	2.333	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
10	CRK	oncoprotein	15	0.495	29.123	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11	CRKL	oncoprotein	12	0.667	7.237	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12	CSF2RA	interactor	2	1.000	0	IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
13	DOK1	suppressor	13	0.485	15.898	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
14	GRAP	interactor	1	0	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
15	GRB10	oncoprotein	4	1.000	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
16	GRB2	oncoprotein	21	0.474	46.333	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
17	GRB7	interactor	1	0	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
18	HSP90B1	suppressor	3	0.667	0.500	CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
19	IL7R	interactor	3	0.667	1.000	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
20	INPP5D	interactor	10	0.711	4.133	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain
21	IRF3	suppressor	3	1.000	0	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
22	JAK2	oncoprotein	15	0.396	37.258	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
23	JAK3	oncoprotein	5	0.500	5.000	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
24	KITLG	oncoprotein	2	0	0	SCF (PF02404, IPR003452): Stem cell factor
25	LCK	oncoprotein	8	0.714	2.105	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26	LYN	oncoprotein	12	0.400	21.056	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27	MATK	oncoprotein	2	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
28	MPDZ	interactor	2	1.000	0	L27_2 (PF09045, IPR015132): L27_2 PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
29	PDGFRA	oncoprotein	9	0.643	5.034	Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain LAT (PF15234, IPR008359): Linker for activation of T-cells
30	PIK3CG	oncoprotein	3	0.667	0.333	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244) DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
31	PIK3R1	oncoprotein	21	0.426	63.259	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
32	PIK3R2	oncoprotein	11	0.673	8.556	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
33	PLCG1	oncoprotein	7	0.714	1.737	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
34	PTPN11	suppressor	13	0.652	11.877	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
35	PTPN6	suppressor	9	0.556	8.230	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
36	PTPRO	interactor	1	0	0	CDC24 (PF06395, IPR010481): CDC24 Calponin fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
37	SH3KBP1	protein found in more fusions	12	0.636	9.146	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
38	SOCS1	suppressor	10	0.533	13.368	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
39	SOCS6	interactor	4	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
40	SRC	oncoprotein	15	0.451	32.795	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
41	STAT1	suppressor	5	0.667	0.686	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
42	STAT5B	oncoprotein	6	0.700	1.667	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
43	TEC	interactor	7	0.619	3.146	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
44	YES1	oncoprotein	3	0.667	0.182	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain YdjC (PF04794, IPR006879): YdjC-like protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain

B a c k t o T o p ⇑

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors