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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins17 (29.82 %)
The number (and %) of the tumor suppressors8 (14.04 %)
Total number of binary PPIs (saturation %)216 (13.53 %)
The number (and %) of affected PPIs55 (25.46 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI7.368
Assortativity coefficient-0.4079
The network average Clustering coefficient0.578
The number (and %) of a zero Clustering coefficients7 (12.28 %)
The number (and %) of a zero Betweenness Centrality19 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CDH2,MALAT1 All fusions
Proteins found in more fusions CREBBP (see 6 fusions); CTNNA1 (see 3 fusions); EXOC5 (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDH2parental protein530.0961946.212Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
2 MALAT1parental protein204.029NA
3 ACTA1interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
4 AGO2interactor30.33319.233ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
5 BOConcoprotein31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
ISET-FN3_linker (PF16625): Unstructured linking region I-set and fnIII on Brother of CDO
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
6 CCNA2oncoprotein50.8330.667Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
7 CDH11suppressor21.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
8 CDH4suppressor100Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
9 CDONoncoprotein31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Glyco_hydro_76 (PF03663, IPR005198): Glycosyl hydrolase family 76
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
10 CREBBPsuppressor41.0000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
11 CTNNA1oncoprotein80.6195.221Vinculin (PF01044, IPR006077): Vinculin family
12 CTNNB1oncoprotein140.26470.232Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
13 CTNND1suppressor41.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
14 DBN1oncoprotein60.6002.900Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
15 DDR1oncoprotein100Lamprin (PF06403, IPR009437): Lamprin
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
16 DDR2suppressor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
17 EXOC5protein found in more fusions31.0000Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
18 FBXO45interactor31.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
F-box-like (PF12937, IPR001810): F-box-like
19 GAAinteractor40.6672.780Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
DUF5110 (PF17137): Domain of unknown function (DUF5110)
20 GNA12oncoprotein100G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
21 GNA13interactor21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
22 IARS2interactor60.6674.069Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
23 ILF3oncoprotein220.229187.649dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
24 JUPsuppressor100.37829.075Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
25 KTN1oncoprotein21.0000ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
26 LRRC7interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
27 MRPL23interactor80.5716.409Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
28 MRPL49interactor60.7331.102Img2 (PF05046, IPR007740): Mitochondrial large subunit ribosomal protein (Img2)
29 MRPL58interactor80.5714.708RF-1 (PF00472, IPR000352): RF-1 domain
30 MTHFD1interactor150.31449.689FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
31 NACA2interactor21.0000NAC (PF01849, IPR002715): NAC domain
32 NENFinteractor170.26558.083Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
33 NTRK1oncoprotein270.163319.648I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 PCinteractor60.6673.821Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
35 PDIA4interactor40.5003.193Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
36 PKP4interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
37 PPT2interactor170.39048.330Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
38 PRKCDBPsuppressor150.34342.292A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
39 PRPHinteractor40.3333.338Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
40 PTBP3interactor40.6672.721RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
41 RAB8Boncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
42 RPL14interactor110.67310.696KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
43 RPL21interactor110.7098.177Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
44 RPL3interactor120.68211.530Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
45 RPL32interactor110.60018.959Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
46 RPL8interactor110.7278.809Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
47 RPS16interactor100.8224.310Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
48 RPS26interactor110.7825.439Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
49 RYKoncoprotein40.6671.167Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
50 SARS2interactor80.5717.022tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312)
DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
51 SKP1oncoprotein50.6004.315Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
52 SPTBN1suppressor60.5334.291CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
53 SSR4interactor50.7002.888TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
54 SUPT5Hinteractor40.6670.861KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
55 TMEM256interactor100DUF423 (PF04241, IPR006696): Protein of unknown function (DUF423)
DUF2648 (PF10855, IPR022561): Protein of unknown function (DUF2648)
56 TPM4oncoprotein50.6004.566Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
57 UBCprotein found in more fusions70.40033.571ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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