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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITGA1, RPS6KA2 (from a repository: Tue Feb 5 11:14:48 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins8 (27.59 %)
The number (and %) of the tumor suppressors4 (13.79 %)
Total number of binary PPIs (saturation %)62 (15.27 %)
The number (and %) of affected PPIs28 (45.16 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI3.379
Assortativity coefficient-0.4954
The network average Clustering coefficient0.343
The number (and %) of a zero Clustering coefficients14 (48.28 %)
The number (and %) of a zero Betweenness Centrality18 (62.07 %)


List of the fusions

PPI for parental proteins: RPS6KA2,ITGA1 All fusions
Proteins found in more fusions LIMK1 (see 1 fusions); FOS (see 4 fusions); CREBBP (see 6 fusions); RPS6KA2 (see 1 fusions); HSP90AA1 (see 5 fusions); LGALS3 (see 2 fusions); MAPK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RPS6KA2parental protein170.125410.600Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
2 ITGA1parental protein110.091314.400FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
3 AUP1interactor100CUE (PF02845, IPR003892, SM00546): CUE domain
4 BIN1suppressor200BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 CREBBPsuppressor70.8005.867Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
6 CSNK2Binteractor31.0000CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
7 ECE2interactor100Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
Peptidase_M48 (PF01435, IPR001915): Peptidase family M48
Methyltransf_25 (PF13649): Methyltransferase domain
8 FAT1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
DUF2808 (PF10989, IPR021256): Protein of unknown function (DUF2808)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Cadherin_3 (PF16184): Cadherin-like
9 FLNCinteractor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
10 FOSoncoprotein51.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
11 GRSF1interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
12 HSP90AA1oncoprotein50.333124.700HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
13 ITGB1suppressor50.50028.600EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin beta chain VWA domain
PSI_integrin (PF17205): Integrin plexin domain
14 JUNoncoprotein70.66713.533bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
15 LAMA1interactor31.0000Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Sec34 (PF04136, IPR007265): Sec34-like family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
16 LGALS3oncoprotein50.500227.700Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
17 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 LIMK1oncoprotein30113.300LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
19 MAPK1oncoprotein70.8005.867Pkinase (PF00069, IPR000719): Protein kinase domain
20 MAPK3oncoprotein70.600239.100Pkinase (PF00069, IPR000719): Protein kinase domain
21 MATN1interactor100VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
Matrilin_ccoil (PF10393, IPR019466): Trimeric coiled-coil oligomerisation domain of matrilin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
22 NQO2interactor200Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
23 RPS6KA1oncoprotein60.53320.333Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
24 SHARPINinteractor200DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
25 SHROOM3interactor100ASD1 (PF08688, IPR014800): Apx/Shroom domain ASD1
ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
26 SLF2interactor100FAM178 (PF14816, IPR026161): Family of unknown function, FAM178
MRI (PF15325, IPR028278): Modulator of retrovirus infection
27 STXBP2interactor100Sec1 (PF00995, IPR001619): Sec1 family
28 TLN1interactor21.0000DUF1013 (PF06242, IPR010421): Protein of unknown function (DUF1013)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Talin_middle (PF09141, IPR015224): Talin, middle domain
VBS (PF08913, IPR015009): Vinculin Binding Site
CoatB (PF10389, IPR008020): Bacteriophage coat protein B
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
29 ZMYM5interactor100DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain

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